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39 projets européens trouvés

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 TERMINÉ 

Mitochondrial regulation of structural and functional plasticity within adult neurogenic circuits (MITOPLASTICITY)

Date du début: 1 août 2016, Date de fin: 31 juil. 2021,

A fundamental question in neuroscience is to reveal the energy constrains governing the plasticity of brain circuits. Mitochondrial energy metabolism is increasingly recognized for regulating the activity and integrity of existing synaptic terminals, however it is unclear how changes in mitochondrial function are coupled with the generation of new neurons and the ensuing circuit remodelling, e.g. ...
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 2

 TERMINÉ 

Boost Brittle Bones Before Birth (BOOSTB4)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Osteogenesis imperfecta (OI) is, in its severe forms, a devastating inherited disorder characterised by brittle bones. A person with severe OI is affected throughout their lifetime with repeated, multiple fractures, considerable pain and handicap. There is no curative or effective treatment for OI. Our preclinical studies and initial clinical cases have demonstrated that transplantation of fetal m ...
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 13

 TERMINÉ 

Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis (CarBon)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

A well-functioning locomotor system is essential for human well-being. This is an important consideration in our aging population with the increased associated costs of ensuring high quality of life. Many people suffer from diseases of the locomotor system, such as bone defects or osteoarthritis, for which current treatments are insufficient. To develop new treatments, CarBon includes 6 academic p ...
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 9

 TERMINÉ 

Investigating the impact of meditation training on mental health and wellbeing in the ageing population (MEDIT-AGEING)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

As the number of older people in Europe grows, increasing healthy life years is a priority. Cognitive decline, dementia (e.g. Alzheimer’s disease, AD), sleep disturbances and depression, all related to psychological distress and anxiety, are significant drivers of reduced quality of life in older adults. This project builds on evidence that lifestyle factors and meditation practice have the potent ...
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 12

 TERMINÉ 

Antibody-Mediated Therapy of HIV-1 Infection (HIV1ABTHERAPY)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Antibodies are destined to neutralize pathogens and can prevent and fight infectious diseases. Over the last years, advances in single B cell cloning resulted in the isolation of highly potent and broad HIV-1 neutralizing antibodies (bNAbs) that have been shown to prevent SHIV infection in non-human primates (NHPs). Recently, we have demonstrated that a combination of bNAbs can suppress HIV-1 repl ...
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 2

 TERMINÉ 

European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry (EN_ACTI2NG)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The EN-ACTI2NG program (European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry) emanates from the recent clinical evidence that T cells expressing engineered tumor-specific immune receptors can eradicate certain tumors that do not respond to conventional treatment. To obtain T cells with reactivity to a wider array of tumors an ...
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 11

 TERMINÉ 

Breast Cancer Risk after Diagnostic Gene Sequencing (BRIDGES) (BRIDGES)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Breast cancer affects more than 360,000 women per year in the EU and causes more than 90,000 deaths. Identification of women at high risk of the disease can lead to disease prevention through intensive screening, chemoprevention or prophylactic surgery. Breast cancer risk is determined by a combination of genetic and lifestyle risk factors. The advent of next generation sequencing has opened up th ...
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 20

 TERMINÉ 

Combatting Bacterial Resistance in Europe - Carbapenem Resistance (COMBACTE-CARE)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2020,

Multi-drug resistant Gram-negative bacteria (MDR-GNB): the ultimate challenge!Antibiotic resistance is a global public health concern recently elevated to the top three threats identified by the WHO, and subject of numerous national and international government activities. Although focused strategies have beneficially influenced infection rates due to methicillin resistant Staphylococcus aureus (M ...
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 23

 TERMINÉ 

Advanced Regenerative and REStorative Therapies to combat corneal BLINDNESS (ARREST BLINDNESS)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Over 30 million Europeans are blind or visually impaired, leading to reduced quality of life and a tremendous loss of productivity in society. Corneal blindness is the second largest cause of blindness globally and while treatable, millions remain unnecessarily blind due to issues of access to transplantable tissue, lack of standardized treatments, and the lag in translating new regenerative medic ...
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 14

 TERMINÉ 

Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases (PRECISESADS)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

We concur to the IMI on “Reclassification of SLE, connective tissue diseases and RA” call by presenting a proposal aimed at using the power of OMICs, and bioinformatics to identify new classifications for diseases known to share common pathophysiological mechanisms. Such knowledge has not been applied to individual patients, depriving them from potential benefits in terms of the use of new therape ...
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 30

 TERMINÉ 

Systems biology for the functional validation of genetic determinants of skeletal diseases (SYBIL)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

"The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth char ...
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 19

 TERMINÉ 

Imaging Voltage Gated Sodium Channels Using Positron Emission Tomography (INSCAPE)

Date du début: 15 mai 2015, Date de fin: 14 mai 2018,

Voltage gated sodium channels (NaVs) are the primary transmembrane proteins underlying fast electrical communication in neurons of the peripheral and central nervous system (PNS and CNS). Being such an integral part of neuronal signaling, they are implicated in a number of severe diseases that have a major impact on human society. However, drugs and established therapies targeting NaVs are rare du ...
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 2

 TERMINÉ 

European Consortium for the Study of a Topical Treatment of iCRVO to prevent Neovascular Glaucoma (STRONG)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2018,

...thogenesis of NVG. Aganirsen is developed by GENE SIGNAL, a SME with expertise in topical ophthalmic treatments for orphan diseases, and manufactured by UNITHER. Under the coordination of the Mainz University Medical Center, a Phase II/III randomised, double-masked, 3-group, placebo-controlled trial (STRONG) is therefore presented to assess Aganirsen’s efficacy in reducing the rate of anterior and ...
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 9

 TERMINÉ 

Mitochondrial unfolded protein response and the role in ageing (MITOUPR)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

"Cells use sensor pathways compartmentalized in subcellular organelles to recognize stress conditions, including aberrant protein folding, and in response activate gene expression programs aimed at maintaining cell survival and restoring homeostasis. Fine-tuning of the protein-folding environment in organelles like mitochondria is important for adaptive homeostasis and may participate in developme ...
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 2

 TERMINÉ 

Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases (Neuromics)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics ...
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 20

 TERMINÉ 

NUTRIENTS AND REGENERATED WATER RECYCLING IN WWTPs THROUGH TWIN-LAYER MICROALGAE CULTURE FOR BIOFERTILIZERS PRODUCTION (LIFE+ TL-BIOFER)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2017,

Background Human activities can have a significant negative impact on the environment, particularly by affecting the global biogeochemical cycles of carbon, nitrogen and phosphorus. Water supplies to urban areas and subsequent sanitation and wastewater systems – even when conventional treatment occurs –produce enormous punctual loadings (point sources ...
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 4

 TERMINÉ 

European Bank for induced pluripotent Stem Cells (EBISC)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2016,

EBiSC is designed to address the increasing demand by iPSC researchers for quality-controlled, disease-relevant research grade iPSC lines, data and cell services. Its goal is to demonstrate an operational banking and distribution service of iPSC lines after 3 years and to establish subsequently for Europe a centralised, not-for-profit bank providing all qualified users with access to scalable, cos ...
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 30

 TERMINÉ 

Improving the lives of Parkinson’s Disease patients while reducing side-effects through tailored deep brain stimulation (IMPACT)

Date du début: 1 sept. 2012, Date de fin: 31 août 2016,

The IMPACT project is about improving the lives of brain diseased patients through a novel approach that leaps beyond currently available Deep Brain Stimulation (DBS) devices and procedures. The initial project focus is on Parkinson’s Disease (PD), but further brain-disease indications will be included in the later phase of the project. The personalized approach that IMPACT brings is essential in ...
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 10

 TERMINÉ 

Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health (Full4Health)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2016,

Full4Health is a multidisciplinary European collaboration of internationally renowned laboratories investigating the mechanisms of hunger, satiety and feeding behaviour, effects of dietary components and food structure on these processes, and their possible exploitation in addressing obesity, chronic disease and under-nutrition. The proposal integrates investigation of both human volunteers (dieta ...
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 16

 TERMINÉ 

Optimisation of treatment with off-patent antimicrobial agents of ventilator-associated pneumonia (VAP) (MagicBullet)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

Background. Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries. Inappropriate empiric antimicrobial treatment is associated with increased mortality. In this context, the empirical treatment of choice for VAP is unknown. Colistin, and “old” dru ...
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 11

 TERMINÉ 

European Communication on Research Awareness Needs (ECRAN)

Date du début: 1 sept. 2012, Date de fin: 31 août 2014,

"The ECRAN (European Communication on Research Awareness Needs) project is designed to develop a portfolio of open educational resources, including a film, for the general population about the challenges raised by independent clinical research.The European Commission (FP7 Health Priority) decided to allocate substantial funding to independent (investigator-driven) clinical trials. Together with me ...
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 10

 TERMINÉ 

A IAPP on the Role of NCAM in Stem Cell Differentiation (STEMCAM)

Date du début: 1 sept. 2010, Date de fin: 31 août 2014,

The STEMCAM project is a 4-years training and transfer of knowledge program between two distinguished academic groups in stem cell research, two highly innovative SMEs and a company leader in development of media for stem cell research, to foster long-term industry-academy collaboration and partnership in the field of stem cells research and applications. The scientific and industrial aim of STEMC ...
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 6

 TERMINÉ 

Deepening our understanding of quality improvement in Europe (DUQUE)

Date du début: 1 nov. 2009, Date de fin: 31 août 2013,

Context Hospitals in European countries apply a wide range of quality improvement strategies; however, knowledge on the effectiveness of these strategies is limited. Objectives We propose to study the effectiveness of quality improvement systems in European hospitals. Specific research objectives are: a) to develop a maturity classification model for the assessment of organizational quality improv ...
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 10

 TERMINÉ 

How does our brain learn to be social? (Social Brain)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2011,

People are per definition social animals. Some even argue that the main reason the human brain is so developed is precisely to support the intricate skills required for successful interactions with others in an increasingly complex social environment. Today, our globalized society indeed requires us to adopt different modes of social interaction in different social contexts, whether this is during ...
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 2

 TERMINÉ 

European IPF Network: Natural course, Pathomechanisms and Novel Treatment Options in Idiopathic Pulmonary Fibrosis (eurIPFnet)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2011,

In the eurIPFnet consortium, leading European basic and clinical scientists in the field of interstitial lung diseases associate to jointly decipher the natural course and molecular pathomechanisms of Idiopathic Pulmonary Fibrosis (IPF) and to develop new therapeutic strategies for patients with IPF. This devastating disease affects about 360.000 patients in the EU and causes a substantial socioec ...
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 13

 TERMINÉ 

Flood Awareness and Prevention Policy in border areas (FLAPP)

Date du début: 31 août 2004, Date de fin: 30 déc. 2007,

The network is seeking to contribute to common European strategies for flood risk management, especially in border areas where flood-related issues are likely to arise. It intends to achieve this by enabling those responsible for European river systems and their feeders to exchange information and experience. FLAPP also expects that its work will influence a new European flood water directive. ...
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 36

 TERMINÉ 

English Profile Network

Date du début: 1 nov. 2009,

The English Profile Network (EPN) is a pan-European network which encompasses different types of educational establishments (schools, universities, private language schools), an internationally renowned publisher and assessment body, plus several research centres and key education professionals. These various organisations hold a wealth of experience and knowledge of all aspects of language teac ...
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 9

 TERMINÉ 

Recall: Games of the Past – Sports for Today

Date du début: 1 janv. 2014,

TAFISA and its transnational, collaborative project partners believe that Traditional Sports and Games (TSG) are part of the world intangible heritage and a symbol of the cultural diversity of our societies. TSG are an effective vehicle to encourage participation in Sport for All and physical activity, and also an efficient means to convey values of solidarity, diversity, inclusion, cultural aware ...
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 13

 TERMINÉ 

“Safeguarding Youth Sport”

Date du début: 1 janv. 2014,

The objective of the project is to promote the idea of protecting physical and moral integrity in competitive youth sport, stimulating individual empowerment of young athletes and conducive ethical climate in sport organisations.The project aims at:•Developing a European network relationships with a focus on improving training and competition conditions in youth sport;• Increasing awareness and kn ...
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 11

 TERMINÉ 

School on Cloud: connecting education to the Cloud for digital citizenship

Date du début: 1 janv. 2014,

The Cloud is a major technological breakthrough with huge potential for education. It allows students and their tutors/teachers to interact productively in formal and informal education situations. Hosted Cloud communities mean that learners themselves can become creators and developers. Laptops and tablets will be everywhere, eBooks will replace text books as a normal part of classroom learning. ...
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 57

 TERMINÉ 

Inter Disciplinary Education Agenda - An essential driver for innovation

Date du début: 15 oct. 2012,

Within the EU and its neighbouring Tempus partner countries, a clear need has risen for an overall societal and educational reform which will challenge existing thinking in higher education modules for the triangle of design, engineering and business. In order to effectively bridge the gaps within the knowledge triangle and support current efforts of industry to cope with global economic challenge ...
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 12

 TERMINÉ 

PIRI REIS: Network, Collaboration and Development for Geographers

VET system for the education and training of geography academics lacks of basic competencies. This is reflected in the number of the quality of the work produced and citation rates in international indexes such as SSCI. One of the main reasons for this is the problem in the vocational educational training (VET) system in geography programs. Geographers trained without sufficient VET skills such as ...
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 8

 TERMINÉ 

IANUS II - Inter-Academic Network ErasmUs MunduS II - Strand 2 - Lot 5

Date du début: 15 juil. 2013,

...l cooperation and to helping to improve students’ career prospects, thus contributing to the improvement of human resources in the countries involved. IANUS II is coordinated by Alexandru Ioan Cuza University of Iaşi, Romania, and the Lot 5 joint coordination is ensured by the National University of Kyiv-Mohyla Academy, Ukraine. The consortium includes 8 EU partner universities from Austria, Franc ...
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 32

 TERMINÉ 

SignLanguage@School

Date du début: 1 nov. 2011,

In 1988 the EU approved a resolution about Sign Languages (SL) and asked all member countries for recognition of their national SL. Although the recognition of SL is meanwhile a standard in the most of the EU member countries, there do exist various barriers in the field of equality of education.The SignLanguage@School project aims at developing & testing SL-Books and corresponding bilingual teach ...
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 9

 TERMINÉ 

Implementation Strategies for Innovations in Teachers´ Professional Development

Date du début: 1 déc. 2013,

The ISIT project addresses two of the crucial needs defined by the Education and Training Benchmarks for 2020 and by the High Level Group of Experts on Literacy (HLGEL 2012):a) the problem of low literacy skills in many European countries b) the unsatisfying status of teachers' continuous professional development (CPD) in the EU.Thus ISIT pursues two goals:a) a specific goal: training 30 teacher e ...
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 11

 TERMINÉ 

Anpassung des Lehrbetriebs an Bolognaprozess im Ingenieurstudium für Aserbaidschan

Date du début: 15 oct. 2011,

In vier Tempusprojekten wurden an vier Universitäten in Aserbaidschan (AZ) moderne Bachelor-/Master-Studiengänge in verschiedenen Spezialisierungen der Elektrotechnik und Umwelttechnik eingerichtet. Diese Studiengänge weisen die gemäß dem Bolognaprozess klare Struktur auf: Durchgehende Modularisierung, Kreditierung , dreistufige Ausbildung.Die Umsetzung der Ziele des Bolognaprozesses in AZ erford ...
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 8

 TERMINÉ 

Ph.D - EU GrAd Students University Skills

Date du début: 1 oct. 2012,

The rationale of PEGASUS is to develop a genuinely integrated EUropean joint Ph.D degree. It starts from the commonly identified need for a transnational Ph.D training on topical EU issues. PEGASUS will pool the excellence in Ph.D training and scientific research of a consortium with a history of long-standing successful cooperation in centres of excellence in EUropean teaching and research.The PE ...
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 6

 TERMINÉ 

Linking Interdisciplinary Integration Studies by Broadening the European Network

Date du début: 1 oct. 2010,

Reason: A New Focal Point for Teaching EU StudiesAs of December 2009, the Lisbon Treaty has become the EU's new fundamental framework for the foreseeable future. The analysis of altered or novel treaty provisions becomes a high priority for interdisciplinary research-based teaching curricula in EU studies. Only a European academic network will be able to exploit input from the relevant disciplines ...
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 67

 TERMINÉ 

European Heritage, Digital Media and the Information Society: an European Master Programme

...re of the programme: staff travel between universities in the first semester and students study in partner universities in the second. In the third and fourth semester students return to their home university where they apply the skills acquired and develop project and thesis work.
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 4