Date du début: 1 avr. 2016,
Date de fin: 31 mars 2021,
During the last four years the Multifun Consortium (FP7 project Nº. 262943) has developed and validated distinct nanoformulations as therapeutic approach against pancreatic and breast cancer. These nanoformulations are based on magnetic iron oxide nanoparticles (MNP) multifuntionalised with a target peptide and an anticancer chemical drug, allowing for a synergistic therapeutic effect produced by ...
Date du début: 1 févr. 2014,
Date de fin: 31 janv. 2019,
Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has relatively rare but considerable risks. Coronary computed tomography (CT) is the most accurate diagnostic test ...
Date du début: 1 nov. 2013,
Date de fin: 31 oct. 2017,
Life threatening infectious diseases and sepsis are worldwide problems with high mortalities. In order to select optimal treatments for the highly heterogeneous group of sepsis patients and to reduce costs, novel multiplexed tools that better characterize the patient and its specific immune response are highly desired.In the novel project "HemoSpec" a multidisciplinary team develops - driven by th ...
Date du début: 1 mars 2012,
Date de fin: 28 févr. 2017,
Healthy brain ageing is a major determinant of quality life-long health, allowing integration into society at all ages. Human epidemiological and animal studies indicate that in addition to life style and genetic factors, environmental influences in prenatal life have a major impact on brain ageing and age-associated brain disorders. We hypothesize that: (1) prenatal stress programs early brain ag ...
Date du début: 1 mars 2011,
Date de fin: 31 août 2016,
Each year more than 63,000 new cases of kidney cancer are diagnosed in the European Union. Approx. 50% of all patients have metastasized renal cell cancer (mRCC) at presentation or develop metastases during follow-up. 5-year relative survival of mRCC has been extremely poor: between 5 and 10%. In the past few years, so-called targeted therapies that suppress angiogenesis have changed the clinical ...
Date du début: 1 juin 2012,
Date de fin: 31 mai 2016,
Inflammatory rheumatic diseases affect millions of European citizens causing chronic pain, disability and premature death. Curative treatments are lacking. Conventional research often focuses on one single organ system such as the bone or the immune system and. ignores interactions between organ systems. OSTEOIMMUNE is a supra-disciplinary training network that targets this gap by providing compre ...
Date du début: 13 juin 2011,
Date de fin: 12 juin 2015,
The aim of the MultiFun consortium is to develop and validate a novel and minimally-invasive nanotechnology system to improve cancer diagnosis and treatment. MultiFun nanotechnology is based on multifunctionalised magnetic nanoparticles to selectively target and eliminate breast and pancreatic cancer (stem) cells. The improved magnetic features of the MultiFun magnetic nanoparticles will lead to p ...
Date du début: 1 nov. 2012,
Date de fin: 31 oct. 2014,
"Therapeutic antibodies are the largest and fastest growing class of pharmaceutical biotechnology products, with annual sales above 30 billion US$. In some cases, antibody products have revolutionized the management of patients, e.g. TNF-blocking antibodies in Arthritis or Rituxan in lymphoma. However, for most antibody therapies, only a subset of patients benefit from treatment. Thus, there is an ...
Date du début: 1 avr. 2010,
Date de fin: 30 juin 2013,
Understanding the dynamics of ligand-gated ion channels is essential for understanding synaptic processes and neuronal signal integration (neurotransmitter gated channels) and intracellular signalling (cyclic nucleotide gated channels). Here we will combine single molecule fluorescence detection, with single channel electrophysiology, to detect ligand-binding and follow subsequent channel gating s ...
Date du début: 1 janv. 2009,
Date de fin: 31 déc. 2012,
The main objective of the proposed project is to develop and to validate a system for measurement and feedback of outcome quality and support of decision making. The project will be executed in the areas of postoperative pain management which serves as an example for other fields of medicine with a high variation of care. The project will provide the medical community with a unique, user-friendly ...
Date du début: 15 mai 2009,
Date de fin: 14 mai 2011,
"Fetal programming of mental and cardiovascular diseases by adverse prenatal environmental influences is a main issue of developmental medicine. However, the number of measurable functional parameters in the human fetus is limited. The assessment of key parameters of the underlying processes of fetal brain maturation could foster the early detection of developmental problems, the design of therape ...
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