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 EN COURS 
Mushrooms are the sexual reproductive structures of basidiomycetes. Much remains to be learned about the molecular regulation of mushroom development. Only a few genes have been implicated in this process, but their exact function remains unknown. Schizophyllum commune is a model system for mushroom-forming fungi. It was recently shown that this species shows the highest intraspecies DNA variabili ...
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 1

 EN COURS 
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 EN COURS 
This project aims to add an important block to syntactic theory, by developing new theoretical tools to account for microvariation and change. The central idea is that change and microvariation are necessary parts of grammar, and that they are in fact constrained by Universal Grammar (Chomsky 1957 ff.); in order to understand them we need not focus on the starting point and endpoint of change only ...
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 1

 EN COURS 
Graphene redirected the pathways of solid-state physics with a revival of 2-D materials showing Dirac physics due to their honeycomb geometry. The charge carriers are fundamentally different from those in conventional electronic systems: the energy vs. wave vector relationship is linear instead of quadratic, resulting in Dirac bands with massless carriers. A genuinely new class of materials will e ...
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 1

 EN COURS 
Great successes have been achieved in nanoscience where the development of functional properties and the assembly of nanostructures into nanomaterials have become increasingly important. In general, both the tuning of the chemical and physical properties and the self-assembly of nanocrystals into 2D or 3D superstructures take place in a liquid environment. When analysing the structural properties ...
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 1

 EN COURS 
Societies cannot survive and thrive if they are not governed well. The public’s business – e.g. security and safety; health and well-being – needs to be managed effectively. Achieving this in the current era of connectivity, transparency, accountability and assertive, skeptical and empowered citizens deeply challenges the institutions of government, which were largely designed for a drastically di ...
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 1

 EN COURS 

Nanobody-targeted photodynamic therapy to kill cancer (KILLCANCER)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

Current cancer therapies often fail to cure patients. Ideally, therapy should locally eradicate cancer and should be capable of inducing long term protection, through activation of the immune system. Photodynamic therapy (PDT) is a treatment approach in which cancer cells are killed with compounds, named photosensitizers that are activated locally through light exposure. Importantly, PDT eradicati ...
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 1

 EN COURS 
Tectonic phenomena at the Earth's surface, like volcanic eruptions and earthquakes,are driven by convection deep in the mantle. Seismic tomography has been very successful in elucidating the Earth's internal velocity structure. However, seismic velocity is insufficient to obtain robust estimates of temperature and composition, and make direct links with mantle convection. Thus, fundamental questio ...
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 1

 EN COURS 

MEthane goes MObile - MEasurements and MOdelling (MEMO2)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2021,

Mitigation of climate change is a key scientific and societal challenge and also a headline target of the EU2020 strategy. Strong reductions in greenhouse gas emissions are necessary to reach the global warming target agreed on at the 2015 United Nations Convention of Parties in Paris. Such emission reductions can only be achieved if sources are properly quantified and mitigation efforts are verif ...
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 9

 EN COURS 

Molecular Adhesion and Interactions in the Nervous system (MAIN)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

Surface-attached proteins establish cell-to-cell contacts and generate signals to control development and function of tissues. It is not clear how protein structure and interactions organize into intercellular assemblies to regulate signalling and adhesion. Using a hybrid approach and focusing on two cell-signalling systems critical for nervous system function, I will determine how protein conform ...
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 1

 EN COURS 

Climbing the Asian Water Tower (CAT)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

The water cycle in the Himalaya is poorly understood because of its extreme topography that results in complex interactions between climate and water stored in snow and glaciers. Hydrological extremes in the greater Himalayas regularly cause great damage, e.g. the Pakistan floods in 2010, while the Himalayas also supply water to over 25% of the global population. So, the stakes are high and an acc ...
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 1

 EN COURS 
Instruct-Ultra aims to advance the scope and efficiency of implementation of Instruct and consolidate the foundations for long-term sustainability. This will be achieved through specific objectives: expand Instruct membership to new Member States and increase global links; engage new user communities; improve efficiencies in service delivery; improve data capture and management; adjust the scale a ...
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 19

 EN COURS 

Digital Crossings in Europe: Gender, Diaspora and Belonging (CONNECTINGEUROPE)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Many immigrants enter Europe both legally and illegally every year. This creates multiple challenges for the Union, including the gender and ethnic segregation of migrant groups, especially women. While it strives for an inclusive and integrated society as envisioned by the EU motto ‘Unity in Diversity’, it is still often perceived more as ‘Fortress Europe.’ This project focuses on the ‘connected ...
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 1

 EN COURS 
All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro a ...
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 14

 EN COURS 
Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical prese ...
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 14

 EN COURS 
Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe.Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal inte ...
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 18

 EN COURS 
ESTUARIES are shallow coastal water bodies with river inflow shaped by biomorphological processes, with patterns of channels and shoals, sand/mud flats, tidal marshes, vegetated banks and peat. Development was influenced by early Holocene landscape that drowned under sealevel rise, and by human interference. Estuaries harbour highly productive natural habitats and are of pivotal economic importanc ...
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 1

 EN COURS 

Realising Innovation in Transitions for Decarbonisation (REINVENT)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

It is high time for the EU to develop pathways and strategies for decarbonisation also in emissions intensive sectors such as steel, plastics, paper, and meat and dairy. These are sectors where low carbon transitions are still relatively unexplored. Some progressive companies and other actors are just beginning to consider such pathways. The overall aim of REINVENT is to help Europe achieve its lo ...
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 5

 EN COURS 
The Paris Agreement substantially increased the need for countries and regions to understand the full economic, social and environmental implications of the deep decarbonisation to which the global community is now committed. The EU has long had decarbonisation ambitions, but there remains considerable uncertainty as to precisely how these ambitions will be achieved, or what the impacts of such ac ...
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 15

 EN COURS 
CHEurope focuses on developing a new integrated theoretical and methodological framework to enhance the academic and professional training and open future job opportunities in cultural heritage preservation, management and promotion. Heritage has commonly been perceived through its contingent relationship to other areas, preventing it to be considered as a ‘legitimate’ scientific discipline. Moreo ...
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 8

 EN COURS 

Educational Network in Ocular Drug Delivery and Therapeutics (OcuTher)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Ocular drug development has transformed from niche area to a major field in drug development in which many companies, including European big pharma has entered recently. Ocular drug development is a unique field in terms of drug targets and end-points of activity, local drug administration routes, tissue barriers and pharmacokinetics, drug delivery and formulation challenges and local toxicity iss ...
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 9

 EN COURS 

Nature Based Urban Innovation (NATURVATION)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Nature-Based Solutions (NBS) have the potential to respond to climate change, enhance biodiversity and improve environmental quality while contributing to economic regeneration and social well-being. Yet there is a substantial gap between the promise of NBS and their uptake. To unlock the potential of NBS for sustainable urban development, NATURVATION will take a transdisciplinary, internationally ...
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 14

 EN COURS 

Connecting Patients and Carers using wearable sensor technology (NIGHTINGALE)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Safest, reliable, individualised care of patients at-risk of deterioration needs patients themselves to play an active role in their care whenever possible: late detection or escalation of deterioration causes avoidable harms, and deaths. In this project we will challenge industry to develop robust monitoring and communications systems that connect patients, carers and health professionals, provid ...
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 5

 EN COURS 
Within the project a new highly efficient biomass CHP technology consisting of a fuel-flexible fixed-bed updraft gasifier, a novel compact gas cleaning system and a solid oxide fuel cell (SOFC) shall be developed for a capacity range of 1to 10 MW (total energy output). The technology shall distinguish itself by a wide fuel spectrum applicable (wood pellets, wood chips, SRC, selected agricultural f ...
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 9

 EN COURS 
This research project will develop a theoretical framework and legal tools to aid scholars and stakeholders (law and policy-makers, private investors, environmental NGOs) in managing competing interests in the offshore economic sector. The offshore sector is expanding and activities at sea are increasing (e.g., deep seabed mining, oil and gas extraction, renewable energy technologies, etc.). This ...
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 1

 EN COURS 
The aim of WORKANDHOME is to develop a new framework for understanding fundamental changes currently taking place to work that situates individuals as economic actors within the context of their wider life domains, household, home and neighbourhood. This will break new ground in how we understand and classify economic activity, the home, the firm, places of economic activity, labour markets and ‘r ...
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 4

 EN COURS 

3D Model Catalysts to explore new routes to sustainable fuels (3MC)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Currently fuels, plastics, and drugs are predominantly manufactured from oil. A transition towards renewable resources critically depends on new catalysts, for instance to convert small molecules (such as solar or biomass derived hydrogen, carbon monoxide, water and carbon dioxide) into more complex ones (such as oxygenates, containing oxygen atoms in their structure). Catalyst development now oft ...
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 1

 EN COURS 
Unlike China, Russia or South Africa, the EU-28 Member States are not in the fortunate position of having vast, easily accessible ore deposits containing valuable metals. However, Europe does have large quantities of secondary industrial residues (tailings, sludges, slags and ashes) that contain sig¬nificant concentrations of both critical and economically important metals. The Euro¬pean Training ...
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 8

 EN COURS 

Technique in the Arts. Concepts, Practices, Expertise (1500-1950) (ARTECHNE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

The transmission of ‘technique’ in art has been a conspicuous ‘black box’ resisting analysis. The tools of the humanities used to study the transmission of ideas and concepts are insufficient when it comes to understanding the transmission of something as non-propositional and non-verbal as ‘technique’. The insights of the neurosciences in, for example, the acquisition and transmission of drawing ...
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 2

 EN COURS 
Severe droughts in Amazonia in 2005 and 2010 caused widespread loss of carbon from the terrestrial biosphere. This loss, almost twice the annual fossil fuel CO2 emissions in the EU, suggests a large sensitivity of the Amazonian carbon balance to a predicted more intense drought regime in the next decades. This is a dangerous inference though, as there is no scientific consensus on the most basic m ...
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 5

 EN COURS 

iABC Programme (IABC PROGRAMME)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

Cystic Fibrosis (CF) is a common fatal inherited disease with a frequency of 1 in 2500 live births, affecting approximately 36,000 (0.737/10,000) people in the EU. Chronic bacterial pulmonary infection leading to an irreversible decline in lung structure and function is the main cause of mortality and morbidity in patients with CF, with more than 95% of deaths due to respiratory failure. Pseudomon ...
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 21

 EN COURS 

Building a Model Cell to Achieve Control of Cellular Organization (MODELCELL)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2020,

A hallmark of profound understanding of the organization of a living cell is the ability to reconstitute essential cellular functionalities from minimal components. To achieve this breakthrough a concerted effort of cell biology, biochemistry and biophysics is required. Our project brings together this expertise to reconstitute the cell’s ability to control the organization of cytoskeletal network ...
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 2

 EN COURS 

3D Bioprinting of JOINT Replacements (3D-JOINT)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,

The world has a significant medical challenge in repairing injured or diseased joints. Joint degeneration and its related pain is a major socio-economic burden that will increase over the next decade and is currently addressed by implanting a metal prosthesis. For the long term, the ideal solution to joint injury is to successfully regenerate rather than replace the damaged cartilage with syntheti ...
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 2

 EN COURS 
Every year, 1.3 million Europeans have a stroke and one million ultimately die of stroke. One third of stroke patients remain dependent on the help of others. The annual costs for stroke care in Europe are estimated at € 64.1 billion. Stroke incidence increases almost exponentially with age, and the personal, societal, and economic burden of stroke is therefore largely driven by its frequent occur ...
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 20

 EN COURS 
Most older adults have multiple chronic diseases (multimorbidity) and multiple medications (polypharmacy). However, multimorbid patients are often excluded from clinical trials and most guidelines address diseases in isolation. Inappropriate drug prescription and poor drug compliance are common and contribute to up to 30% of hospital admissions. OPERAM investigators developed STOPP/START criteria ...
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 9

 TERMINÉ 

Zoonotic Anticipation and Preparedness Initiative (ZAPI)

Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,

Emerging infectious diseases are occurring at increasing frequency in Europe and other regions of the world, having profound impacts on public and/or veterinary health as well as disruptive effects on sector, regional or even global economy. The predominantly zoonotic nature of emerging pathogens calls for a One Health approach uniting the human medical and veterinary fields, dedicated to swiftly ...
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 21

 TERMINÉ 

A multiscale approach towards mesostructured porous material design (MULTIMAT)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

"MULTIMAT addresses (1) the industrial and societal need for affordable materials that have a highly defined and large porosity together with the required (mechanical, chemical and/or thermal) robustness for application in thermal insulation, catalysts, fuel cells and oil spill remediation and (2) the scientific need to better understand the mechanisms underlying the assembly of small building blo ...
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 8

 TERMINÉ 

Colloidal Nanomaterials for Smart Applications (COMPASS)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

"The COMPASS project unites key players in Europe and the US with the aim to advance the field of colloidal nanocrystal (NC) synthesis and assembly and their exploitation in photonics, sensing, energy conversion and medicine. COMPASS aims to (i) develop colloidal NCs with desired properties by controlling their size, shape and composition, and to demonstrate routes allowing for large production vo ...
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 4

 TERMINÉ 
The objective of SponGES is to develop an integrated ecosystem-based approach to preserve and sustainably use vulnerable sponge ecosystems of the North Atlantic. The SponGES consortium, an international and interdisciplinary collaboration of research institutions, environmental non-governmental and intergovernmental organizations, will focus on one of the most diverse, ecologically and biologicall ...
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 19

 TERMINÉ 
The SUBITOP ETN is a framework for training and career development of young researchers in Geodynamics, Geophysics, Geology and Geomorphology. It has a scientific focus on the dynamics of continental margins where tectonic plates are recycled through subduction. Subduction processes have shaped and govern many aspects of the topography of Europe, and other continents, and they determine the patte ...
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 10