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Plus de 40 projets européens trouvés

Recherche sur 125080 projets européens

 EN COURS 

Spin-Delocalization with a Twist: Chiral Open-Shell Helices (INSPIRAL)

Date du début: 1 avr. 2017, Date de fin: 31 mars 2022,

Spin-delocalization in molecules containing unpaired electrons gives rise to an unusual intermolecular interaction, named as pancake bond. This bonding interaction couples unpaired electrons between multiple pairs of atoms from each face-to-face oriented spin units, such as phenalenyl radical, and abets formation of assemblies that display large antiferromagnetic interaction in the solid state. Th ...
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 1

 EN COURS 

Molecular Mechanical Adhesives (MMA)

Date du début: 1 avr. 2017, Date de fin: 31 mars 2022,

Protein-based hydrogels are commonly used as adhesives and sealants in surgical settings. Fibrin gels, for example, are biocompatible, however their use is hampered by poor mechanical properties. Previous attempts to improve fibrin gel mechanics relied on interpenetrating networks in combination with PEO, collagen and other polymers, however, only modest improvements were observed. The important c ...
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 1

 EN COURS 
Nature is a rich source of biologically active molecules, among which the largest and most diverse group of natural products are terpenes. Essential drugs like the cancer medication taxol/paclitaxel or the malaria drug artemisinin belong to the terpene family. They are efficiently formed in nature through a so-called tail-to-head terpene cyclization. Chemists are not able to mimic this process wit ...
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 1

 EN COURS 
Breast cancer is diagnosed in ~1.4 million women worldwide and ~500,000 lives are lost to the disease annually. Patients may do well after surgery and initial treatment, but drug resistant and fatal metastases often develop. Improved treatment options are urgently needed. The connecting thread of this project is the identification of epigenetic drivers of breast cell fate, tumor heterogeneity and ...
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 2

 EN COURS 

Directed Evolution of Artificial Metalloenzymes for In Vivo Applications (DrEAM)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

In the past decade, artificial metalloenzymes (AMs) have emerged as an attractive alternative to the more traditional enzymes and homogeneous catalysts. Such hybrid catalysts result from the incorporation of an abiotic metal cofactor within a macromolecule (protein or oligonucleotide). Artificial metalloenzymes combine attractive features of both homogeneous catalysts and enzymes, including the po ...
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 1

 EN COURS 

Alternative Splicing Codes for Synaptic Specificity (SPLICECODE)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

Neuronal networks represent an impressive example of highly organized complex systems. Sperry postulated that selective neuronal connectivity is achieved by chemoaffinity labels. Several such labels for axon guidance and topographic mapping have been defined. However, until recently, molecules that direct the recognition of synaptic partners and functional specification of synapses have remained o ...
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 1

 EN COURS 

Signal Integration by Gene Regulatory Landscapes (INTEGRAL)

Date du début: 1 août 2016, Date de fin: 31 juil. 2021,

Identification of the molecular mechanisms by which gene regulatory landscapes integrate diverse signaling inputs into a robust and dynamic transcriptional output is key to a comprehensive mechanistic understanding of the systems that govern vertebrate organogenesis. We will tackle this by taking advantage of our in-depth knowledge of the self-regulatory signaling systems controlling vertebrate li ...
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 1

 EN COURS 

Fluid Flows and Irregular Transport (FLIRT)

Date du début: 1 juin 2016, Date de fin: 31 mai 2021,

"Several important partial differential equations (PDEs) arising in the mathematical description of physical phenomena exhibit transport features: physical quantities are advected by velocity fields that drive the dynamics of the system. This is the case for instance for the Euler equation of fluid dynamics, for conservation laws, and for kinetic equations.An ubiquitous feature of these phenomena ...
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 1

 EN COURS 
The project seeks to explore culinary practice among early farming European communities, from the Aegean to Central Europe, spanning the Neolithic through to the Iron Age (7th-1st millennia BC). The project seeks to identify the ‘food cultures’ of prehistoric Europe, and to reconstruct how cultivated and wild plant foods were transformed into dishes exploring their underlying cultural and environm ...
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 5

 EN COURS 
Breast cancer is the most common cancer in women, resulting in as many as 500000 deaths per year worldwide. Patients with breast cancer die unequivocally because of the development of incurable distant metastases and not because of symptoms related to the primary site. Understanding the complex, yet fundamental mechanisms driving breast cancer metastasis is critical to develop therapies tailored t ...
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 1

 EN COURS 

Novel Quantum Emitters monolithically grown on Si, Ge and III-V substrates (4PHOTON)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

We propose to forge a partnership between the leading European groups working on the next generation of solid state quantum emitters based on novel growth methods such as Droplet Epitaxy. Future, practical Nano-photonics and Quantum Circuits applications demand semiconductor quantum dots that can be grown on substrates with different lattice parameters (Si, Ge, GaAs), different substrate orientati ...
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 11

 EN COURS 

Modular mechanical-atomic quantum systems (MODULAR)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Atomic ensembles are routinely prepared and manipulated in the quantum regime using the powerful techniques of laser cooling and trapping. To achieve similar control over the vibrations of nanofabricated mechanical oscillators is a goal that is vigorously pursued, which recently led to the first observations of ground-state cooling and quantum behavior in such systems.In this project, we will expl ...
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 1

 EN COURS 
In PlantHUB will capture the academic, industrial and regulatory expertise from 5 world-class universities, 1 public research organisation, 1 governmental organization, 8 enterprises including 5 SMEs to train 10 ESRs in skills and competencies necessary to apply responsible research and innovation (RRI) in the area of plant breeding and production. We wish to address the demand of RRI leadership i ...
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 10

 EN COURS 

Mechanisms of Evasive Resistance in Cancer (MERiC)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2020,

Cancer is a major health problem due to the failure of current therapies to effectively eradicate the disease. Alternative signaling pathways compensate for a therapeutically targeted pathway, a process referred to as 'evasive resistance'. The identities of the alternative signaling pathways and functional interconnections that underlie evasive resistance remain widely unknown. We propose to integ ...
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 3

 EN COURS 
Most older adults have multiple chronic diseases (multimorbidity) and multiple medications (polypharmacy). However, multimorbid patients are often excluded from clinical trials and most guidelines address diseases in isolation. Inappropriate drug prescription and poor drug compliance are common and contribute to up to 30% of hospital admissions. OPERAM investigators developed STOPP/START criteria ...
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 9

 TERMINÉ 

Imaging the Force of Cancer (FORCE)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastat ...
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 18

 TERMINÉ 

Nanoscale solid-state spin systems in emerging quantum technologies (Spin-NANO)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

This network brings together world-leading experts in nano-science and technology from 6 European countries in order to achieve breakthroughs in understanding and successful utilization of nanoscale solid-state spin systems in emerging quantum technologies. The proposed innovative science in the supra-disciplinary field of physics and applications of spin nano-systems will underpin breakthrough de ...
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 11

 TERMINÉ 

BIOengineered grafts for Cartilage Healing In Patients (BIO-CHIP) (BIO-CHIP)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

Spontaneous healing of articular cartilage injuries is poor and untreated defects predispose to osteoarthritis. Current therapies, including innovative autologous cell-based treatments, cannot predictably and reproducibly restore cartilage structure and function. BIOCHIP will carry out a multicenter, prospective phase II clinical trial to treat knee cartilage injuries using engineered grafts based ...
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 9

 TERMINÉ 

Deciphering PI3K biology in health and disease (Phd)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

The Phosphoinositide 3-kinase (PI3K) pathway is at the core of multiple fundamental biological processes controlling metabolism, protein synthesis, cell growth, survival, and migration. This inevitably leads to the involvement of the PI3K signalling pathway in a number of different diseases, ranging from inflammation and diabetes to cancer, with PI3K pathway alterations present in almost 80% of hu ...
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 11

 TERMINÉ 
The ability of cells to polarize underlies the most basic biological functions such as motility and response to external challenges, but also the formation and maintenance of tissues in a multicellular organism. The importance of cell polarity is underscored by the fact that cell polarity is essential for animal development and is perturbed in disease states such as cancer. Understanding cell pola ...
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 9

 TERMINÉ 
This project takes a new look at an old text. The Bible is a fundamental book for the history of religious beliefs, cultural history, art history as well as many other fields. For centuries it has been read and copied multiple times. Thousands of medieval manuscripts survive. The process of transmission is considered here from a totally new perspective. While biblical manuscripts have so far been ...
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 2

 TERMINÉ 
The Eurozone crisis corroborated the warnings of economists that weak economic policy coordination and loose fiscal oversight would be insufficient to stabilise the monetary union. To prevent a recurrence of the crisis, economists, political actors and the “Blueprint” of the European Commission are asking for the construction of a deep and genuine economic and monetary union with reinforced govern ...
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 10

 TERMINÉ 

The organisation of functional microcircuits in visual cortex (NeuroVision)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

Determining how the organisation of neural circuitry gives rise to its function has been a major challenge for understanding the neural basis of perception and behaviour. In order to uncover how different regions of the neocortex process sensory information, it is necessary to understand how the pattern and properties of synaptic connections in a specific sensory circuit determine the computations ...
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 1

 TERMINÉ 

European Virus Archive goes global (EVAg)

Date du début: 1 avr. 2015, Date de fin: 31 mars 2019,

The overall objective will be to create and mobilise an International network of high calibre centres around a strong European group of institutes selected for their appropriate expertises, to collect, amplify, characterise, standardise, authenticate, distribute and track, mammalian and other exotic viruses. The network of EVAg laboratories including 25 institutions represents an extensive range o ...
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 27

 TERMINÉ 
"Regular physical activity is linked to improved health and increased life expectancy. Inversely, a sedentary life-style is a strong and independent risk factor for many chronic diseases, including obesity, type 2 diabetes or cardiovascular disorders, as well as certain types of cancer or neurodegeneration. Interestingly however, the molecular mechanisms that mediate the health beneficial effects ...
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 1

 TERMINÉ 
"More than 150 years after the publication of Charles Darwin’s The Origin of Species, the identification of the processes that govern the emergence of novel species remains a fundamental problem to biology. Why is it that some groups have diversified in a seemingly explosive manner, while others have lingered unvaried over millions of years? What are the external factors and environmental conditio ...
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 2

 TERMINÉ 
When interacting with the environment we depend on our perception of the world around us. Visual perception relies on information flow from the eye to the visual cortex, where it is relayed and transformed via a series of cortical processing stages. Most research so far has focused on feedforward processing of visual information. However, it is increasingly obvious that perception crucially depend ...
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 1

 TERMINÉ 
The ubiquitous FIC domain catalyzes post-translational modifications (PTMs) of target proteins; i.e.adenylylation (=AMPylation) and, more rarely, uridylylation and phosphocholination. Fic proteins arethought to play critical roles in intrinsic signaling processes of prokaryotes and eukaryotes; however, asubset encoded by bacterial pathogens is translocated via dedicated secretion systems into the ...
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 1

 TERMINÉ 

Enzymology of oxidative sulfur transfers (ErgOX)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Oxidative stress causes cancer, cardiovascular, neurodegenerative and infective disease. Much of cellular oxidative stress is mediated, communicated, mitigated or amplified by a complex system of sulphur containing small metabolites or protein based cysteines. Characterization of key players and reactions in this network is crucial for preventive and therapeutic interventions.I propose a new persp ...
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 1

 TERMINÉ 

EUROPEAN ROBOTIC GOAL-ORIENTED AUTONOMOUS CONTROLLER (ERGO)

Date du début: 1 nov. 2016, Date de fin: 31 janv. 2019,

European Robotic goal-oriented autonomous COntroller (ERGO)The specific objective of ERGO is thaen to deliver the most advanced but flexible space autonomous framework/system suitable for single and/or collaborative space robotic means/missions (orbital and surface rovers) demanding robust operations with adaptable levels of autonomy.Due to the intrinsic similarities of addressed scenarios, especi ...
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 8

 TERMINÉ 

"State Space Exploration: Principles, Algorithms and Applications" (SSX)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"State-space search, finding paths in huge, implicitly given graphs, is a fundamental problem in artificial intelligence and other areas of computer science. State-space search algorithms like A*, IDA* and greedy best-first search are major success stories in artificial intelligence, and hundreds of papers based on variations of these algorithms are published every year. Due to this success, the m ...
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 1

 TERMINÉ 
The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Express ...
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 49

 TERMINÉ 

Bottom-up Nanowires as Scanning Multifunctional Sensors (NWScan)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Advances in growth and fabrication of semiconductor nanostructures have led to both the production of exquisitely sensitive force transducers and the development of solid-state quantum devices. Force transducers, typically monolithic Si cantilevers, are central to techniques such as AFM, and MFM. On the other hand, quantum devices including quantum wells, quantum dots (QDs), and single electron tr ...
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 1

 TERMINÉ 

Personalised Prognostic Tools for Early Psychosis Management (PRONIA)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Affective and non-affective psychoses have a major negative impact on human society. They account for 6.3% of the global burden of disease and cost €207 billion per year in Europe alone, making them the most expensive brain-related disorders and even more expensive than cardiovascular diseases. This socioeconomic burden is largely caused by two core disease features: onset in adolescence and early ...
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 13

 TERMINÉ 

Accelerated Development of Vaccine benefit-risk Collaboration in Europe (ADVANCE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Aim: The ADVANCE vision is focused on Timely and Best Evidence on Vaccine Effects. Our mission is to establish a best practice framework to rapidly provide robust data on vaccine benefits and risks to support accelerated decision-making.Approach: To achieve this vision through a public-private partnership, ADVANCE partners 1. establish common grounds and rules for collaboration between public and ...
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 30

 TERMINÉ 

Reservoir Computing with Real-time Data for future IT (RECORD-IT)

Date du début: 1 sept. 2015, Date de fin: 31 août 2018,

The aim of this proposal is to develop an intelligent biocompatible sensing device which detects complex behavioural changes in ion concentrations. The sensor will use wet NOMFETs, coated Si nanowires, self-conjugated polymers, arrays of photocells, flow of lipids. The level of ions will be measured by monitoring changes in the response function of the system. The high sensitivity of the device wi ...
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 9

 TERMINÉ 

Memory B cell immunity in chronic viral infection (IMMUNIBY)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

This project aims for a quantum leap in the understudied area of memory B cell immunity to chronic viral infection. It provides i) a landscape analysis of primary and memory B cell responses to chronic viral challenge, ii) investigates receptor hypermutation of memory B cells for broadened protection against viral escape variants, and iii) studies the role of memory CD4+ T cells in augmenting memo ...
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 2

 TERMINÉ 
One of the greatest challenges facing regulators in the ever changing landscape of novel nano-materials is how to design and implement a regulatory process which is robust enough to deal with a rapidly diversifying system of manufactured nanomaterials (MNM) over time. Not only does the complexity of the MNM present a problem for regulators, the validity of data decreases with time, so that the wel ...
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 46

 TERMINÉ 

Time, space and speed: cdGMP signaling in cell behavior and reproduction (cdGMP)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,

Bacterial biofilms are the primary cause of chronic infections and of resulting infection relapses. To be able to interfere with bacterial persistence it is vital to understand the molecular details of biofilm formation and to define how motile planktonic cells transit into surface-grown communities. The nucleotide second messenger cyclic di-guanosinemonophosphate (cdGMP) has emerged as a central ...
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 1

 TERMINÉ 

Human Brain Project Specific Grant Agreement 1 (HBP SGA1)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses I ...
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 126