12 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Bioactivated hierarchical hydrogels as zonal implants for articular cartilage regeneration (HYDROZONES)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
Degeneration of cartilage is a major cause of chronic pain, lost mobility and reduced quality of life for millions of European citizens. From a clinical point of view treatment to achieve cartilage regeneration (hyaline) and not only repair (fibrous) remains a great challenge. No clinical therapy is available that leads to healing of cartilage defects.Current cartilage implants cannot establish th ...
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18
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TERMINÉ
Early warning signals of ageing in human stem cells and age-related disorders (SYSTEMAGE)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
The regenerative power of a living organism is linked to the potential of its stem cells to replace the corresponding damaged tissue. Therefore organisms are as old as their stem cells. Whereas the vulnerability to cancer and chronic inflammation is associated with a decline of the immune system, the latter is in turn a sum product of interactions among hematopoietic stem cells (HSC), endothelial ...
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11
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TERMINÉ
Small Artery Remodelling (SmArteR)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
Cardiovascular disease remains a major cause of morbidity and mortality in Europe. Small arteries form a key element in the pathogenesis. Thus, these vessels dictate local perfusion and blood pressure by adaptation of their caliber. Structural changes towards smaller caliber, small artery remodelling, cause hypertension and decreased organ perfusion, leading to acute events and chronic end organ d ...
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11
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TERMINÉ
The molecular and cellular basis of structural plasticity and reorganisation in chronic pain (PAIN PLASTICITY)
Date du début: 1 juil. 2012, Date de fin: 30 juin 2017,
"Chronic pain is a serious medical problem and a socioeconomic burden that severely reduces quality of life worldwide. Neural plasticity constitutes a key element of pathological pain, which can come about over various anatomical and temporal scales. Apart from functional plasticity, tremendous potential exists for changes in the structure, connectivity and representation of pain, which can accoun ...
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1
Participant partenaire
TERMINÉ
Glioma Actively Personalized Vaccine Consortium (GAPVAC)
Date du début: 1 nov. 2012, Date de fin: 31 janv. 2017,
"Glioblastoma (GBM) is a rare (2-3 incidences in 100,000) and fatal disease. Each year, approximately 13,000 new cases of GBM are diagnosed in Europe. The 5-year survival rate of this highly aggressive tumor entity under conventional therapy is less than 6%. Currently available therapeutic options neglect the individuality of each patients’ disease and only temporarily influence tumor progression ...
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13
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TERMINÉ
The Sugar Code: from (bio)chemical concept to clinics (GLYCOPHARM)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,
Coding of biochemical information is commonly described to be based solely on nucleotides and amino acids, whereas carbohydrates, the most abundant type of molecule in Nature, appear sidelined in this respect. That carbohydrates, as part of cellular glycoconjugates, have exceptional talents for building biochemical signals is an emerging insight, at the heart of the concept of the Sugar Code. Intu ...
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11
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TERMINÉ
Innovative tools and strategies for surveillance and control of dengue (DengueTools)
Date du début: 1 sept. 2011, Date de fin: 30 avr. 2016,
Current surveillance systems and control efforts are clearly insufficient to combat dengue in endemic countries and to prevent spread to previously uninfected areas (including Europe). We will focus on the following aspects of the call: better diagnosis, surveillance, prevention as well as prediction and/or prevention of the spread of Dengue fever to previously uninfected regions (including Europe ...
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14
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TERMINÉ
Impact of Proteasome Subpopulations on Cardiac Remodeling (PROCARE)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
Heart disease is the number one cause of death in Europe and the world. Cardiac remodeling involving cardiac hypertrophy is associated with higher morbidity as well as mortality due to heart disease. Cardiac muscle mass is potentially influenced by the ubiquitin proteasome system (UPS). At the heart of the UPS is the proteasome, which specifically degrades targeted proteins into peptides. The cand ...
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1
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TERMINÉ
INDEPTH Training and Research Centres of Excellence (INTREC)
Date du début: 1 janv. 2012, Date de fin: 30 juin 2015,
The major causes of poor health are rooted in our societies. Governments are encouraged to lead global action on the social determinants of health with the aim of achieving health equity. This requires setting-specific, timely and relevant evidence on the relationship between determinants and outcomes which is yet limited, especially in low- and middle-income countries (LMICs). This calls for rese ...
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6
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TERMINÉ
Implant Disposable Antibacterial Coating (I.D.A.C.): a Novel Approach to Implant-Related Infections in Orthopaedics and Trauma Surgery (I.D.A.C.)
Date du début: 1 janv. 2012, Date de fin: 30 juin 2015,
With a share of 38%, orthopaedic and traumatology (O&T) are the worldwide leading markets of implanted biomaterials, involving millions of new patients each year at an increasing trend. Infection related to implanted medical devices is directly related to bacterial capability to establish multilayered, highly structured biofilms on artificial surfaces. Bacterial infections due to implanted biomate ...
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13
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TERMINÉ
Enabling business-based Internet of Things and Services - An Interoperability platform for a real-world populated Internet of Things domain (ebbits)
Date du début: 1 sept. 2010, Date de fin: 28 févr. 2015,
The ebbits project aims to develop architecture, technologies and processes, which allow businesses to semantically integrate the Internet of Things into mainstream enterprise systems and support interoperable real-world, on-line end-to-end business applications. It will provide semantic resolution to the IoT and hence present a bridge between enterprise applications, people, services and the phys ...
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9
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TERMINÉ
Molecular Analysis of Hepatitis C Virus Neutralization and Entry For the Development of Novel Antiviral Immunopreventive Strategies (HEPCENT)
Date du début: 1 avr. 2009, Date de fin: 31 déc. 2014,
Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease world-wide. HCV-induced end-stage liver disease such as liver cirrhosis and hepatocellular carcinoma represent a major concern in global health. Treatment options for chronic hepatitis C are limited and no vaccine against HCV infection is available. Vaccine development is hampered by several obstacles. High viral variabi ...
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