3 projets européens trouvés
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TERMINÉ
Single Molecule Investigations in Living E. coli (SMILE)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
The overall ambition is to make intracellular measurements that bridge the gap between quantitative physical models and biological observations, in order to identify and resolve inconsistencies in our current understanding of life at the molecular level.We are particularly interested in answering fundamental questions about how the molecules that regulate gene expression and DNA replication operat ...
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1
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TERMINÉ
X-RAY LASERS, PHOTON SCIENCE, AND STRUCTURAL BIOLOGY (XLASERS)
Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,
Theory predicts that with an ultra-short and very bright coherent X-ray pulse, a single diffraction pattern may be recorded from a large macromolecule, a virus, or a cell before the sample explodes and turns into a plasma. The over-sampled diffraction pattern permits phase retrieval and hence structure determination. The first free-electron lasers (FELs) capable to deliver ultra bright and very sh ...
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1
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TERMINÉ
Transcription Factor Dynamics in Living Cells at the Single Molecule Level (TF dynamics in vivo)
Date du début: 1 juil. 2008, Date de fin: 30 juin 2013,
Progress in bioengineering and biomedicine is limited by our inadequate understanding of genetic control systems in living cells. The lack of methods for studying kinetics and gene regulation in single cells seriously impairs our prospects to gain deeper insight to develop better quantitative models of such control systems. This project is focused on transcription factors (TFs), proteins that medi ...
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