10 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Tumour Heterogeneity and Somatic Evolution of Unstable cancer genomes (THESEUS)
Date du début: 1 juin 2014, Date de fin: 31 mai 2019,
SummaryThe majority of metastastic solid tumours remain incurable. In-depth analysis of tumour genomes is revealing evidence for branched evolution and cancer subclonal spatial and temporal intratumour heterogeneity (ITH). Drivers of ITH such as chromosomal instability (CIN) are associated with drug resistance and poor clinical outcome. However, despite increasing knowledge of tumour diversity, th ...
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3
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TERMINÉ
Design Principles of Microtubule Cytoskeleton Architectures during Cell Division (SPINDLEDESIGN)
Date du début: 1 juil. 2013, Date de fin: 30 juin 2018,
The microtubule cytoskeleton provides an intracellular coordinate system and a mechanical scaffold for a multitude of essential cellular functions. The design principles underlying the dynamic organisation and function of the microtubule cytoskeleton are not understood. Using an in vitro reconstitution approach, we will determine the rules that govern which combination of mechano-chemical elements ...
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2
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TERMINÉ
Targeting RAS oncogene addiction (RASTARGET)
Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,
Lung cancer is the most common type of malignant tumour worldwide and the leading cause of cancer-related death (335,000 deaths per year in Europe). The KRAS oncogene is frequently activated by point mutation in human lung cancer and mutations in the RAS family oncogenes are responsible for driving some 20% of all human malignancies. Most cell lines from RAS mutant tumours remain “oncogene addicte ...
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2
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TERMINÉ
ATMINistrating ATM signalling: exploring the significance of ATM regulation by ATMIN (ATMINDDR)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2018,
ATM is the protein kinase that is mutated in the hereditary autosomal recessive disease ataxia telangiectasia (A-T). A-T patients display immune deficiencies, cancer predisposition and radiosensitivity. The molecular role of ATM is to respond to DNA damage by phosphorylating its substrates, thereby promoting repair of damage or arresting the cell cycle. Following the induction of double-strand bre ...
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2
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TERMINÉ
MAL: an actin-regulated SRF transcriptional coactivator (ACTINONSRF)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2017,
MAL: an actin-regulated SRF transcriptional coactivatorRecent years have seen a revitalised interest in the role of actin in nuclear processes, but the molecular mechanisms involved remain largely unexplored. We will elucidate the molecular basis for the actin-based control of the SRF transcriptional coactivator, MAL. SRF controls transcription through two families of coactivators, the actin-bindi ...
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2
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TERMINÉ
Cross-species characterisation of CD8alpha+ dendritic cells and their role in immune regulation (DCSUBSET)
Date du début: 1 sept. 2011, Date de fin: 31 août 2017,
Dendritic cells (DC) are a heterogeneous family of leucocytes with important functions in immunity. Little is known about the role of distinct DC subtypes in vivo. In the mouse, a subset known as CD8alpha+ DC has been argued to represent a discrete DC lineage with specialised properties. These include a superior capacity for presenting exogenous antigens to CD8+ and CD4+ T cells, which makes CD8al ...
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2
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TERMINÉ
Sorting processes that ensure short and long-range action of Wnts in developing epithelia (WNTEXPORT)
Date du début: 1 juil. 2012, Date de fin: 30 juin 2017,
Wnts are signaling proteins that act both at short and long range in developing tissues. Several proteins, such as Wntless, are specifically devoted to Wnt secretion, indicating that Wnts may follow a distinct secretory route. Moreover, Wnts carry two lipid modifications, which are likely to interfere with diffusion in the extracellular space. Much of our work will focus on the trafficking of Wing ...
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2
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TERMINÉ
Novel Approaches to Determine Molecular Mechanisms of Pathogenesis in Tuberculosis (TB-PATH)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,
I initiated and developed an unbiased comprehensive study using whole genome array analysis of the transcriptome in blood of tuberculosis (TB) patients and provided global knowledge of the immune response and potential factors leading to TB pathogenesis. Using larger cohorts of TB patients and controls than previous studies, together with complementary analytical approaches of modular, pathway and ...
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2
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TERMINÉ
Transcription and the maintenance of genome integrity (TRANSINTEG)
Date du début: 1 mai 2011, Date de fin: 30 avr. 2016,
Maintaining genome integrity is crucial, especially in protein-encoding genes. DNA damage in genes can give rise to harmful mutations, but it can also directly obstruct the progress of transcribing RNA polymerase II (RNAPII), thereby blocking gene expression. Not surprisingly, repair pathways have evolved that specifically target lesions that stop RNAPII during its journey across a gene, so-called ...
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2
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TERMINÉ
Regulating recombination in mitotic and meiotic cells (RECMITMEI)
Date du début: 1 mai 2011, Date de fin: 30 avr. 2016,
DNA is a highly reactive molecule that is subject to deliberate, spontaneous and environmental damage. One of the most catastrophic lesions in DNA is the double-strand break (DSB), which if left unrepaired can result in cell death, infertility, genome instability and cancer. Homologous recombination (HR) is a largely error-free mechanism of DSB repair that utilizes an intact sister or homologous c ...
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