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Dobutamine for NEOnatal CIRCulatory failure defined by novel biomarkers (NEO-CIRC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2018,

Dobutamine and adrenaline are widely used as second line therapy for systemic hypotension in infants. Dopamine is currently the most widely used first line drug. In neonates, sustained hypotension may, and impaired organ perfusion will, cause brain injury and poor neurodevelopmental outcomes. All three catecholamines are currently used off-label and have different modes of action which may result ...
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