9 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Modeling Disease through Cell Reprogramming: a Translational Approach to the Pathogenesis of Syndromes Caused by Symmetrical Gene Dosage Imbalances (DISEASEAVATARS)
Date du début: 1 sept. 2014, Date de fin: 31 août 2019,
The fundamental limitation in our ability to dissect human diseases is the scarce availability of human tissues at relevant disease stages, which is particularly salient for neural disorders. Somatic cell reprogramming is overcoming this limitation through the derivation of patient-specific induced pluripotent stem cells (iPSC) that can be differentiated into disease-relevant cell-types. Despite t ...
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3
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TERMINÉ
Global immunopeptidome landscape of normal and Mycobacterium tuberculosis-infected human cells (IMMUNOPEPTIDOMICS)
Date du début: 1 sept. 2013, Date de fin: 31 août 2015,
MHC class I-associated peptides are presented at the cell surface for scrutiny by CD8+ T lymphocytes and are collectively referred to as the immunopeptidome. The immunopeptidome plays crucial roles in many processes including autoimmunity, cancer immunosurveillance and elimination of pathogen-infected cells. Nevertheless, very little is known about the molecular composition and biogenesis of the i ...
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1
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TERMINÉ
Systems biology of Mycobacterium tuberculosis (SYSTEMTB)
Date du début: 1 avr. 2010, Date de fin: 30 sept. 2014,
Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the world's population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to ...
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14
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TERMINÉ
International Data Exchange and Data Representation Standards for Proteomics (ProteomeXchange)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2014,
Over the last few years the field of proteomics has evolved into a prolific data producer. As a result, various databases that collect and redistribute the acquired data have been established. While data format standards for quantitative proteomics have now been defined and implemented with significant contribution from the recently completed EU ProDaC grant, standards for quantitative proteomics ...
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13
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TERMINÉ
Proteomics v3.0: Development, Implementation and Dissemination of a Third Generation Proteomics Technology (PROTEOMICS V3.0)
Date du début: 1 avr. 2009, Date de fin: 31 mars 2014,
Quantitative proteomics is a key technology for the life sciences in general and for systems biology in particular. So far, however, technical limitations have made it impossible to analyze the complete proteome of any species. It is the general goal of this proposal to develop, implement, apply and disseminate a new proteomic strategy that has the potential to generate quantitative proteomic dat ...
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1
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TERMINÉ
Detecting protease substrates using unnatural amino acids (Tagging Proteolysis)
Date du début: 1 mai 2011, Date de fin: 30 avr. 2013,
There are aminoacyl transferases, such as arginyl tRNA protein transferase 1 (Ate1) in Eukaryotes and leucyl/phenylalanyl tRNA protein transferase (L/F transferase) in Bacteria. Both enzymes recognize specific N-terminal amino acids of a target poly-peptide and conjugate an amino acid from an aminoacylated tRNA onto the N-terminus of the targeted poly-peptide.Ate1 conjugates an arginyl moiety ont ...
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1
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TERMINÉ
A systems approach linking genotype and environment to phenotype: oxidative stress response mechanisms in fission yeast (PhenOxiGEn)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,
Cellular protection against oxidative damage is relevant to ageing and numerous complex diseases. We plan to use fission yeast as a model organism to gain a systems-level understanding of the oxidative stress response and obtain insights into the interplay of variable genotype, phenotype, and environment. To this end, the four participants will pursue a range of multi-disciplinary and complementin ...
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4
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TERMINÉ
Systems Biology of Cancer Kinome (Cancer Kinome)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2011,
Protein kinases mediate most of the signal transduction events in cells by phosphorylation of specific substrates – modifying their activity, cellular location, and/or association with other proteins. The extremely critical role of kinases for critical cellular decisions came evident when an unexpectedly large number of kinases (120/518) were found to be mutationally activated activated or their e ...
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1
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TERMINÉ
A Systems Biology Approach to Elucidate the Yeast Metabolic Network (MRM-Yeast Metabolism)
Date du début: 1 mai 2008, Date de fin: 30 avr. 2010,
The ultimate goal of systems biology is to generate mathematical models to comprehensively describe the dynamics of a biological system. Among all biochemical and informational systems that operate in cells, metabolism is unique because the composition and topology of the network of metabolic reactions is almost completely known. What is currently poorly understood, is how this system operates, ho ...
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