4 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Reactive oxygen species (ROS) as Elixirs against chronic Disease: OXidative regulatory mechanisms In T cells and neutrophils. (REDOXIT)
Date du début: 1 juil. 2015, Date de fin: 30 juin 2019,
We are proposing a four-year programme of knowledge transfer and networking between Aston University (ASTON, UK), Universitatsklinikum Erlangen (UKER, Germany) and Redoxis AB (Redoxis, Sweden). Our proposal targets an emerging area of biology, i.e. reactive oxygen species (ROS)-mediated regulation of immune responses; it brings together the application of small molecule candidate drugs to generate ...
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3
Participants partenaires
TERMINÉ
BeTheCuRE (BTCURE)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2017,
BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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41
Participants partenaires
TERMINÉ
NOX enzymes as mediators of inflammation-triggered neurodegeneration: modulating NOX enzymes as novel therapies (NEURINOX)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,
NEURINOX aims at elucidating the role of NADPH oxidases (NOX) in neuroinflammation and its progression to neurodegenerative diseases (ND), as well as evaluating the potential of novel ND therapeutics approaches targeting NOX activity. NOX generate reactive oxygen species (ROS) and have emerged as regulators of neuroinflammation. Their role is complex: ROS generated by NOX lead to tissue damage in ...
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15
Participants partenaires
TERMINÉ
Mechanisms to Attack Steering Effectors of Rheumatoid Syndromes with Innovated Therapy Choices (Masterswitch)
Date du début: 1 déc. 2008, Date de fin: 30 nov. 2013,
Objective: To delineate the biological and molecular pathways that initiate and drive chronic inflammatory disease and to transform the knowledge obtained into the development of novel anti-inflammatory interventions. Focus will be given to Rheumatoid Arthritis (RA) since longitudinal data indicate that intensive treatment can prevent persistency and chronicity. State of the Art and beyond: The ...
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