3 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Markers for emphysema versus airway disease in COPD (EvA)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,
COPD is characterized by emphysema (destruction of the lung alveoli) and airway disease (inflammation and thickening of the bronchial wall) both of which lead to airway obstruction. These two features co-exist in most patients but some patients present with only emphysema (E) or only airway disease (A). The aim of the project is to identify markers specific to E and A of COPD. Our hypothesis is th ...
Voir le projet
15
Participants partenaires
TERMINÉ
Adipokines as Drug Targets to Combat Adverse Effects of Excess Adipose Tissue (ADAPT)
Date du début: 1 févr. 2008, Date de fin: 31 janv. 2012,
"Obesity represents the major risk factor for the cardiometabolic syndrome, which is an epidemic disease that generates a severe global socio-economic burden for the public health systems. Enhanced production of proinflammatory adipocytokines by expanded adipose tissue is now considered as a key event in the pathogenesis of this syndrome. This process involves i) the systemic release of adipokines ...
Voir le projet
12
Participants partenaires
TERMINÉ
Understanding of ORMDL3 biology will provide novel insight into the pathogenesis of asthma (Asthma and ORMDL3)
Date du début: 1 mai 2009, Date de fin: 31 juil. 2011,
Asthma affects up to 30 million children and adults in Europe and many more around the world. Today, asthma can be treated but not cured. Major efforts to understand the mechanisms leading to the disease are needed to better intervene and potentially prevent asthma.Genetic susceptibility and environmental factors are thought to cause the disease. However, until recently systematic approaches to id ...
Voir le projet