6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
European Autism Interventions - A Multicentre Study for Developing New Medications (EU-AIMS)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,
Despite dramatic advances in molecular and imaging technologies, there are currently no effective pharmacological treatments for the core symptoms of autism spectrum disorder (ASD). Major obstructions to this include a lack of aetiologically-driven or pathophysiologically-accurate animal models; an absence of tests that indicate efficacy; and reliance of clinical trials on DSM/ICD10 categories wh ...
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29
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TERMINÉ
Synaptic Systems: dissecting brain function in health and disease (SYNSYS)
Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,
Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and ...
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19
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TERMINÉ
Investigating the role of Neuroligin-4 in the development of autism-related synaptic and behavioral abnormalities in mice (NL-4 IN AUTISM)
Date du début: 1 oct. 2010, Date de fin: 30 sept. 2014,
"Autism is a frequent neurodevelopmental disorder, characterized by impairments in social interaction, language deficits, and repetitive behaviors. The biological basis of autism remains unknown, and no cure or effective pharmacological treatment is currently available. Given the high prevalence of autism and the devastating consequences for patients and families, it is essential to improve our un ...
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1
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TERMINÉ
NANOTECHNOLOGICAL TOOLKITS FOR MULTI-MODAL DISEASE DIAGNOSTICS AND TREATMENT MONITORING (NAMDIATREAM)
Date du début: 1 juil. 2010, Date de fin: 30 juin 2014,
NAMDIATREAM will develop a cutting edge nanotechnology-based toolkit for multi-modal detection of biomarkers of most common cancer types and cancer metastases, permitting identification of cells indicative of early disease onset in a high-specificity and throughput format in clinical, laboratory and point-of-care devices. The project is built on the innovative concepts of super-sensitive and highl ...
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24
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TERMINÉ
European Consortium on Synaptic Protein Networks in Neurological and Psychiatric Diseases (EUROSPIN)
Date du début: 1 janv. 2010, Date de fin: 30 juin 2014,
"Signalling at nerve cell synapses - a key determinant of all aspects of brain function - depends on the function of hundreds of synaptic proteins and their interactions. Numerous recent studies showed that a wide range of neurological and psychiatric diseases are 'synaptopathies' whose onset and progression are due to mutations of synaptic proteins and subsequent synaptic dysfunctions. EUROSPIN w ...
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19
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TERMINÉ
When Neurons Touch-Elucidating the Role of Neuroligins in the Formation, Development, Maturation, and Maintenance of Synapses (Synapse NL)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2013,
The proper coupling between presynaptic and postsynaptic neurons is essential for synaptic signalling. Synapse formation, maturation, and maintenance are controlled by cell adhesion systems that recruit and organise the synaptic protein machinery. One such system comprises presynaptic neurexins and postsynaptic neuroligins. Of the five known neuroligins, neuroligin 1 is specific for excitatory syn ...
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