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27 projets européens trouvés

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 TERMINÉ 

Combatting Bacterial Resistance in Europe - Carbapenem Resistance (COMBACTE-CARE)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2020,

Multi-drug resistant Gram-negative bacteria (MDR-GNB): the ultimate challenge!Antibiotic resistance is a global public health concern recently elevated to the top three threats identified by the WHO, and subject of numerous national and international government activities. Although focused strategies have beneficially influenced infection rates due to methicillin resistant Staphylococcus aureus (M ...
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 23

 TERMINÉ 

Combatting Bacterial Resistance in Europe (COMBACTE-NET)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2019,

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies. The estimated costs of ARB are aro ...
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 38

 TERMINÉ 

Physiology of the Intestine: Proteases from the Epithelium (PIPE)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

"In several gastrointestinal diseases such as irritable bowel syndrome or inflammatory bowel diseases, proteolytic homeostasis is disrupted. This disruption has an important impact of the pathophysiology of those diseases. We hypothesized that intestinal epithelial cells are major regulators of this homeostasis by secreting proteases and protease inhibitors, thereby interfering with gut biologica ...
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 1

 TERMINÉ 

Biomarkers of renal graft injuries in kidney allograft recipients (BIOMARGIN)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

In renal allograft recipients, 10-year graft survival has not improved over the past decades. Histological examination of graft biopsies has long been the gold standard to confirm graft injuries, but biopsies are invasive and histological grading is not very robust. There is thus a need for robust, non-invasive methods to predict and diagnose acute and chronic graft lesions, to improve patient tre ...
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 13

 TERMINÉ 

European Medical Information Framework (EMIF)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

In response to the need to tackle increasingly complex medical research questions, a growing amount of human health data is being collected, either in routine Electronic Healthcare Record (EHR) databases, through research-driven cohort studies, in biobanks or related efforts. However, data sources are typically fragmented and contain information gaps which prevent their full exploitation. EMIF aim ...
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 64

 TERMINÉ 

Healthy Aging Through Internet Counselling in the Elderly (HATICE)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

"Diabetes mellitus, hypertension, obesity, hypercholesterolemia, smoking and physical inactivity are common in elderly persons and are all associated with an increased risk of myocardial infarction, stroke and dementia. Efficacious treatments of these cardiovascular diseases are available, but in elderly patients with multiple cardiovascular diseases and risk factors however, treatment is currentl ...
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 7

 TERMINÉ 

Reach α-synuclein-dependent neurodegeneration: clinical development of therapeutic AFFITOPE vaccines for Parkinson’s disease and multisystem atrophy (SYMPATH)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

The goal of SYMPATH is to advance clinical development of therapeutic vaccines targeting α-synuclein (aSyn)-driven neurodegenerative diseases (ND). It addresses Parkinson’s disease (PD) and multiple system atrophy (MSA), two synucleopathies, for which no causal therapy exists. Ultimately, both lead to patient disability and death, which along with patient number (PD) and age of onset (MSA, PD) def ...
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 8

 TERMINÉ 

Clinical and system –omics for the identification of the MOlecular DEterminants of established Chronic Kidney Disease (iMODE-CKD)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

iMODE-CKD integrates multi-disciplinary expertise in proteomics, metabolomics, transcriptomics, bioinformatics, pathology, and clinical science from leading academic and industrial investigators, establishing a unique training platform on biomarker research and Systems Biology. Special emphasis is placed on the application of a wide range of –omics and bioinformatics techniques to clinical researc ...
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 10

 TERMINÉ 

Initial Training Network for Neurogical disorders orchestrated by cytoKines (NEUROKINE)

Date du début: 1 janv. 2013, Date de fin: 31 mai 2017,

Neuroinflammatory disease, in particular multiple sclerosis affects more than 700.000 people within Europe alone. European countries are at the forefront of neuroimmunological research and students in medicine and biology are greatly attracted by the field. Neuroimmunology research further impacts our understanding of the ethiopathology of other CNS-disorders including Alzheimer’s Dementia and Mor ...
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 13

 TERMINÉ 

"Role of Themis1, a new T cell signaling protein, in normal and pathological immune responses" (THEMIS)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

"A critical step of an immunological response is the activation of T lymphocytes through intracellular signaling pathways downstream of T cell receptors (TCR). THEMIS1 is a new actor of T cell signaling that belongs to a newly identified family of proteins. THEMIS proteins each contain a previously uncharacterized globular domain (called 'CABIT') whose structure and function are currently unknown. ...
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 1

 TERMINÉ 

BBMRI - Large Prospective Cohorts (BBMRI-LPC)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2017,

In recent years, biomedical research has crossed international borders in large, collaborative studies showing the value of multidisciplinarity and scale advantage. This has yielded valuable insights and some led to new and better medicines and treatments for diseases. However, disease-focused studies provide less insight in the real disease onset, the relative disease burden in the population, an ...
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 36

 TERMINÉ 

Best EScalation Treatment in Multiple Sclerosis (MS) (BEST MS)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

"Multiple Sclerosis (MS) is a devastating disease of the central nervous system affecting 2.5 million worldwide. MS is a field of constant therapeutic innovation, a fact which brings hope to young adults since MS is one of the most frequent causes of severe handicap. A major unmet need is to rationalize treatment decisions. To date, there is no way of predicting which patients will best respond to ...
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 5

 TERMINÉ 

Cell-based regenerative medicine: new challenges for EU legislation and governance (EUCelLEX)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,

This proposal aims at collecting and analysing facts and figures in order to assess the current legislation on the therapeutic use of somatic cells, and to bridge it with the research infrastructure capacity building. Although EU has adopted 3 Directives on Tissues and cells between 2004 and 2006 to harmonise the procurement, storage and use of cells for therapeutic use in Europe, countries have i ...
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 9

 TERMINÉ 

European collaborative project on Targeted therapy in renal cell cancer: genetic and tumor-related biomarkers for response and toxicity (EuroTARGET)

Date du début: 1 mars 2011, Date de fin: 31 août 2016,

Each year more than 63,000 new cases of kidney cancer are diagnosed in the European Union. Approx. 50% of all patients have metastasized renal cell cancer (mRCC) at presentation or develop metastases during follow-up. 5-year relative survival of mRCC has been extremely poor: between 5 and 10%. In the past few years, so-called targeted therapies that suppress angiogenesis have changed the clinical ...
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 15

 TERMINÉ 

THE ROLE OF ELASTASE/ELASTASE INHIBITOR IN DIALOG BETWEEN INTESTINAL EPITHELIAL CELLS AND MACROPHAGES IN INFLAMMATORY BOWEL DISEASES CONTEXT (EPIMACase)

Date du début: 6 août 2014, Date de fin: 5 août 2016,

Inflammatory Bowel Diseases (IBD) are chronic disorders for which aetiology is unknown and only palliative care is available for patients. In Europe, 2.2 million people suffered of ulcerative colitis or Crohn's disease in Europe, the socio-economic impact of IBD is very heavy. Thus, the development of new and more effective treatments for IBD depends upon a better understanding of the regulation o ...
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 1

 TERMINÉ 

Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes (DIABAT)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,

"The DIABAT project will employ knowledge of the function, dysfunction and physiological regulation of brown adipocytes to develop innovative therapeutic and preventive strategies for type 2 diabetes. Brown adipose tissue (BAT) is currently a worldwide recognized target to combat obesity and diabetes due to last years re-discovery of functional BAT in adult humans by several of the members of the ...
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 22

 TERMINÉ 

Introducing diagnostic applications of ‘3Gb-testing’ in human genetics (3GB-TEST)

Date du début: 1 sept. 2013, Date de fin: 31 août 2015,

The landscape of genetic testing is rapidly changing. Soon, whole genome sequence analysis (3Gb-testing) will be an effective and financially viable alternative to targeted gene analysis. New technologies that allow efficient sequencing of a whole human genome in a diagnostic setting will have an enormous impact on diagnostic centres replacing many existing molecular and cytogenetic tests.Patients ...
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 11

 TERMINÉ 

European Sequencing and Genotyping Infrastructure (ESGI)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,

The objective of this project is the integration of world class high-throughput sequencing and genotyping facilities that will provide sequencing and genotyping technologies and data analysis methodologies to the scientific community.The European Sequencing and Genotyping Infrastructure (ESGI) will enable external users to generate data rapidly and to acquire knowledge efficiently. By providing ac ...
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 11

 TERMINÉ 

The role of intestinal microflora in non-alcoholic fatty liver disease (NAFLD) (FLORINASH)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,

As worldwide metabolic disease pandemics rise relentlessly with their concomitant clinical complications such as non alcoholic fatty liver disease, FLORINASH proposes an innovative research concept to address the role of intestinal microfloral activity in the pathogenesis of NAFLD. Firstly, to discover novel metabolic markers for the differential diagnosis and prediction of patient risk. Secondly, ...
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 6

 TERMINÉ 

Identifying Strategies to Manipulate the Immune System to Increase the Control of Tumors and Metastases (ISMISICOTAM)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2014,

"The number of cancer patients is increasing and effective treatments are still limited. The identification of tumor associated antigens (TAA) has allowed for the stimulation of the immune system to recognize and destroy solid tumors. The most common strategy is to increase tumor specific cytotoxic CD8 T cell responses by vaccination of the patient with dendritic cells (DCs) pulsed with TAA peptid ...
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 1

 TERMINÉ 

Antigen processing and T cell recognition of intravacuolar parasites (APATRIVAP)

Date du début: 28 juin 2010, Date de fin: 27 juin 2014,

"Antigen recognition by CD8 T cells enables us to combat infectious pathogens, such as viruses and parasites. This feature represents the groundwork for vaccine efficacy. Immune surveillance is achieved by screening short peptides presented by major histocompatibility complex (MHC) class I molecules on the surface of infected cells. Recognition of foreign peptide-MHC I complexes triggers cytokine ...
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 1

 TERMINÉ 

In vivo characterisation of Follicular Helper T cells (TFHcells)

Date du début: 1 juin 2010, Date de fin: 31 mai 2014,

An effective immune response relies on the helper T cell (TH) regulated development of high-affinity B cell memory. Follicular Helper T (TFH) cells are the critical regulators of the B cell response. Until recently, TFH cells were considered fully differentiated cells prone to apoptosis. However, we showed that protein vaccination selects locally effector TFH cells that become memory TFH cells and ...
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 1

 TERMINÉ 

IMPROVEMENT OF TOOLS AND PORTABILITY OF MASS SPECTROMETRY-BASED CLINICAL PROTEOMICS AS APPLIED TO CHRONIC KIDNEY DISEASE (PROTOCLIN)

Date du début: 15 mai 2010, Date de fin: 14 mai 2014,

The number of patients with chronic kidney disease (CKD) is increasing steadily due to extended life expectancy, long lasting diabetes and obesity. Early unambiguous detection of patients at risk is both a clinical and scientific challenge. Capillary electrophoresis coupled to mass spectrometry (CE-MS), developed by Mosaiques Diagnostics (MD, SME, Germany), has been shown to be an excellent tool f ...
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 4

 TERMINÉ 

Characterisation of PI3K isoform roles in pancreatic cancerogenesis (PaCa/PI3K)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2014,

PI 3-kinases (PI3Ks) are key signal transduction enzymes which are generally considered to be excellent new targets for therapeutic interference. Mammals have multiple PI3K isoforms.During my UK post-doctoral training funded by EIF, I have created and characterized new mouse models targeting one isoform of PI3K, p110beta, which physiological role was unknown. Isoform-specificity of p110beta in cel ...
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 1

 TERMINÉ 

Sharing capacity across Europe in high-throughput sequencing technology to explore genetic variation in health and disease (GEUVADIS)

Date du début: 1 oct. 2010, Date de fin: 31 déc. 2013,

"High-throughput next-generation DNA sequencing technologies allow investigators to sequence entire human genomes at an affordable price and within a short time frame. The correct interpretation, storage, and dissemination of the large amount of produced genomics data generate major challenges. Tackling these challenges requires extensive exchange of data, information and knowledge between medical ...
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 17

 TERMINÉ 

Development of biotherapies for growth plate disorders (GeneCellTher)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

Skeletal dysplasias are a diverse and heterogeneous group of hereditary disorders characterized by malformations of bone and cartilage. These conditions affect development patterns in bones of growing children, and the clinical severity ranges from mild short stature to highly disfiguring, and even to lethal forms. Their treatment is very challenging, typically with no or limited success. This pro ...
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 1

 TERMINÉ 

"Ethical, Legal, Social and Practical Barriers to Sharing between Biobanks in Europe" (ELSPBSBBE)

Date du début: 1 sept. 2011, Date de fin: 31 août 2013,

"Biological samples, such as tissues, DNA, and cells are an increasingly important resource for advancing research on human diseases. In the last two decades, important efforts have been made to organize such samples and data into biobanks in order to make these samples and data available for sharing between researchers. That being said, there remains many barriers and challenges to sharing betwe ...
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 2