Date du début: 1 nov. 2012,
Date de fin: 31 oct. 2017,
Most biopharmaceuticals (BP) currently on the market are recombinant proteins which are parenterally administered. These would benefit from more patient-friendly routes of administration. Moreover, new classes of BP (e.g. siRNA, miRNA, DARPins) with specificity for intracellular targets hold promise but await the advent of efficient delivery systems before their potential can be realised into ther ...
Date du début: 1 août 2012,
Date de fin: 31 juil. 2017,
"The goal of the current proposal is to provide a new empirical foundation to our knowledge of sound patterns that are statistically underrepresented (typologically rare) in the world's languages. Typologically rare patterns have been claimed to be more difficult to produce and perceive, and more prone to undergo sound change. Yet this claim is controversial: others maintain that due to the stabil ...
Date du début: 1 juin 2012,
Date de fin: 31 mai 2017,
"The aim of the proposal is to relate historical sound change to the acquisition of the temporal control of speech. The motivation for the experiments is that the mis-perception of timing relationships and the failure to normalize perceptually for context effects are driving forces for sound change; and that such mis-perception is especially likely during the relatively long period between early c ...
Date du début: 1 oct. 2011,
Date de fin: 30 sept. 2016,
"Optical microscopy forms the basis of most of the natural sciences. Besides the direct visualization of objects hidden to the unaided human eye, optical spectroscopy – or in other words “colour vision”- is of prime importance providing information on electronic and vibronic properties. In addition, experiments using ultrafast laser pulses provide the highest possible temporal resolution enabling ...
Date du début: 1 sept. 2011,
Date de fin: 31 août 2016,
"The advent of laser frequency combs a decade ago has revolutionized optical frequency metrology. Such combs have become enabling tools for a growing tree of applications, from optical atomic clocks to attosecond science.Recently, the millions of precisely controlled laser comb lines produced with a train of ultrashort laser pulses have been harnessed for highly multiplexed molecular spectroscopy. ...
Date du début: 1 mai 2011,
Date de fin: 30 avr. 2016,
"Blindness affects millions of people worldwide and has devastating consequences for those affected. It is often caused by a loss of photoreceptors in the retina, whose residual cellular network remains largely unaffected. Various strategies have been chosen to restore vision, such as electrical stimulation with retinal implants. More recently, natural photoreceptor proteins and stem cells have be ...
Date du début: 1 mai 2011,
Date de fin: 30 avr. 2016,
"The regulation of gene transcription governs eukaryotic cell growth and differentiation. Despite its importance, transcription regulation is not understood at a mechanistic level. Regulation occurs mainly during initiation, when the enzyme RNA polymerase II (Pol II) assembles with ~50 polypeptides on promoter DNA. Regulatory signals are transmitted by the 25-subunit Mediator, and convert the init ...
Date du début: 1 mars 2011,
Date de fin: 29 févr. 2016,
"The cell membrane is the biological platform for many vital processes such as photosynthesis, cell-cell contact, biomolecular recognition, endocytosis and ion transport. Artificial phospholipid membranes play an important role in unravelling the physical and chemical characteristics of membranes and their microscopic role in membrane function. On the other hand a manifold of novel hybrid nanosyst ...
Date du début: 1 janv. 2011,
Date de fin: 31 déc. 2015,
Raman spectroscopy is one of the most specific non-destructive optical techniques to identify the chemical composition of a sample. Further, there is great hope that in the future it may be a powerful biomedical imaging technique for in vitro or in vivo microscopy, providing molecular contrast without exogenous contrast agents.However, due to the small Raman cross-section, for many applications th ...
Date du début: 1 mai 2010,
Date de fin: 30 avr. 2015,
Asthma and allergies are chronic conditions affecting billions of Europeans. These complex diseases are determined by interplay of genetic and environmental factors. Treatments can control symptoms, but cannot cure or prevent the diseases. I, and my team, have shown that children are strongly protected from asthma and allergies when growing up in a farming environment rich in microbial exposures: ...
Date du début: 1 mars 2010,
Date de fin: 28 févr. 2015,
State-of-the-art microscopy and diffraction imaging provides insight into the atomic and sub-atomic structure of matter. They permit determination of the positions of atoms in a crystal lattice or in a molecule as well as the distribution of electrons inside atoms. State-of-the-art time-resolved spectroscopy with femtosecond and attosecond resolution provides access to dynamic changes in the atomi ...
Date du début: 1 janv. 2010,
Date de fin: 31 déc. 2014,
This project aims to uncover and clarify phylogenetic relationships between native South American languages. Very little is known about the historical development of the linguistic diversity in this part of the world, and more detailed insights will have a major impact not only on linguistics, but also on genetics, archeology, and cultural anthropology. The approach taken is to digitize available ...
Date du début: 1 déc. 2008,
Date de fin: 30 nov. 2014,
The use of organometallic reagents in the last decades completely changed synthetic organic chemistry. These reactive intermediates made now available new materials with outstanding physical properties, novel drugs with excellent activity spectra, modern highly efficient and ecologically benign agrochemicals. The goal of this work is the development of new synthetic routes and a practical access t ...
Date du début: 1 sept. 2008,
Date de fin: 31 août 2013,
Eukaryotic gene expression is a highly regulated, fundamental cellular process encompassing distinct steps such as transcription, mRNA processing and nuclear export, translation and degradation of the mRNA. In this project a novel level in the regulation of gene expression will be analyzed. We propose that transcription and the correct processing as well as packaging of the newly synthesized mRNA ...
Date du début: 1 avr. 2009,
Date de fin: 31 mars 2012,
"This project is unique as it identifies a totally new field within Narratology: multiple future narratives. Narratives are traditionally concerned with past events. Even if they claim to be about the future (e.g., utopian tales), narratives treat these events as if they had already happened. In contrast, future narratives in our sense are narratives that preserve the characteristic feature of fut ...
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