4 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Molecular basis of the outer membrane permeability (TRANSLOCATION)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
Overcoming the barriers that the cell envelope and efflux pumps provide to Gram-negative bacteria is a major bottleneck in the discovery and development of new antibiotics. To respond to this Call we are extending our current network on antibiotic translocation and propose an ambitious project ranging from identification of novel resistance mechanisms in clinical bacterial isolates to crystallizat ...
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28
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TERMINÉ
Kinetics for Drug Discovery (K4DD) (K4DD)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,
There is mounting evidence that the often ignored kinetic aspects of the interaction between a drug and its target are highly relevant for clinical success. This ignorance may be one of the reasons for the high attrition rates in drug discovery, as it has been analyzed that many recently marketed drugs had indeed improved kinetic profiles. This hindsight knowledge needs to be converted into data-d ...
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21
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TERMINÉ
Chronotherapeutic lifestyle intervention for diabetes and obesity to reset the circadian rhythm and improve cardiometabolic risk in the European working population (EURHYTHDIA)
Date du début: 1 oct. 2011, Date de fin: 30 juin 2017,
Modern lifestyle has dramatically changed the daily rhythms of life. Physical activity, diet and light exposure are no longer restricted to daytime hours, as technical and economical de-mands fuel the necessity to work outside usual working hours. Recent studies show that al-tered light exposure, shifted exercise patterns and untimely food intake following extended active periods into the night di ...
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17
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TERMINÉ
Hanging Drop based automated and parallelized cell technology platform for production and testing (DropTech)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2017,
Cell-based screenings are today a necessary tool for all types of clinical development and/or market approval of new drugs and chemicals. The major change in the last decade is a shift towards more physiologically relevant yet complex and sensitive cell models, like stem cells, and more recently, the shift to human induced pluripotent cells. Stem-cell technology has the potential to revolutionize ...
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