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22 projets européens trouvés

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 TERMINÉ 

Adhesion switches in cancer and development: from in vivo to synthetic biology (ADHESWITCHES)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

Integrins are transmembrane cell adhesion receptors controlling cell proliferation and migration. Our objective is to gain fundamentally novel mechanistic insight into the emerging new roles of integrins in cancer and to generate a road map of integrin dependent pathways critical in mammary gland development and integrin signalling thus opening new targets for therapeutic interventions. We will co ...
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 1

 TERMINÉ 

Intergenerational Cumulative Disadvantage and Resource Compensation (INDIRECT)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

"The previous literature has not been able to successfully explain why the loss of the certain family resources does not show as a weaker attainment. Neither the country differences in socioeconomic inheritance seem to reflect the institutional differences between them. We argue that these problems have followed from ignoring resource compensation. The lost capital (economic, human/cultural or soc ...
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 1

 TERMINÉ 

AN INNOVATIVE CAUSAL THERAPY FOR ALLERGY: SAFE AND RAPID INDUCTION OF AN ANTI-INFLAMMATORY IMMUNE RESPONSE USING A MUTANT HYPOALLERGEN AND VITAMIN D3 (BM4SIT)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Allergy is the most prevalent chronic inflammatory disease, having great socio-economic impact. Chronic lifelong dependency on symptomatic drugs is an expensive reality for the vast majority of allergy sufferers. Allergen-specific immunotherapy is the only causal and effective treatment targeting the underlying immune mechanism in a more cost-effective way. Yet, long treatment duration and risk of ...
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 10

 TERMINÉ 

Personalised Prognostic Tools for Early Psychosis Management (PRONIA)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Affective and non-affective psychoses have a major negative impact on human society. They account for 6.3% of the global burden of disease and cost €207 billion per year in Europe alone, making them the most expensive brain-related disorders and even more expensive than cardiovascular diseases. This socioeconomic burden is largely caused by two core disease features: onset in adolescence and early ...
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 13

 TERMINÉ 

Personalized diagnosis and treatment of hyperinsulinemic hypoglycaemia caused by beta-cell pathology (BETACURE)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2018,

Background:Hyperinsulinaemic hypoglycaemia (HH) is a potentially lethal disease caused by over functioning beta cells derived from the pancreatic islets of Langerhans. Lethal HH and brain damage is a problem especially in infants with congenital HH. Current therapeutic approaches are associated with severe side effects/morbidity (diabetes, exocrine pancreas insufficiency etc.) considered acceptabl ...
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 17

 TERMINÉ 

Ark of Inquiry: Inquiry Awards for Youth over Europe (Ark of Inquiry)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,

The Ark of Inquiry project aims to raise youth awareness to Responsible Research and Innovation (RRI) by providing young European citizens (7 to 18-year-olds) with a pool of engaging inquiry activities to improve their inquiry skills, increase their awareness and understanding of conducting ‘real’ science, and prepare them to participate in different roles in the European research and innovation p ...
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 13

 TERMINÉ 

Academia-Industry Research and Development Opportunities for Picornaviruses (AIROPico)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

Viruses belonging to the large family of Picornaviridae such as enteroviruses, rhinoviruses and parechoviruses represent the most commonly encountered infectious agents in mankind. Several research groups in Europe are active on different aspects of picornavirus research. Nevertheless, prevalence, transmission, and pathogenesis are still largely unknown and no therapy is available for picorna infe ...
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 10

 TERMINÉ 

Exploring Functional and Developmental Osteoclast Heterogeneity in Health and Disease (EUROCLAST)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

Euroclast proposes a research training program on osteoclast biology in the context of osteoclast-driven diseases. Osteoclasts are the complex, multinuclear cells responsible for bone breakdown. Many diseases of osteoclast malfunctioning manifest in bone loss, for example, osteoporosis, cancer-induced bone disease, periodontitis, or rheumatoid arthritis, all conditions set to increase in an ageing ...
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 11

 TERMINÉ 

Development of very promising humanized therapeutic mAbs efficiently neutralizing a novel immunosuppressive pathway involved in a wide range of cancers (TumAdoR)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

Studies have demonstrated the importance of CD73 in the spread of cancer. Overexpressed in numerous cancer types, this enzyme leads to the production of high amounts of extracellular Adenosine, creating an immunosuppressive microenvironment, and contributing to tumor proliferation and dissemination. Neutralizing its activity represents a highly potent and innovative therapy.Following on the recent ...
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 8

 TERMINÉ 

Brain Imaging Return to Health (r'BIRTH)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

Extended lifespan is a new and permanent feature of human life globally. The demographic for population growth of persons over 60 years is predicted to expand by 70% and 400% respectively in developed and less developed regions during the coming decades. Ageing, is accompanied by cognitive decline and greater risk of depression and anxiety. Major drug companies have recently cutback significantly ...
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 10

 TERMINÉ 

Ports Observatory for Performance Indicator Analysis (PORTOPIA)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

PORTOPIA aims to develop, next to extensions of existing indicators within the different perspectives of port performance, innovative approaches for the industry's stakeholders, such as:• Development of a forecasting dimension in port performance management within the market trends and structure category;• Development of top-down methods for harmonised socio-economic impact calculation;• Developme ...
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 12

 TERMINÉ 

Neuroimaging platform for characterisation of metabolic co-morbidities in psychotic disorders (METSY)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

"The theme of this collaborative project is development and application of neuroimaging and bioinformatics tools to study lipid metabolism as a common pathogenic link between psychotic disorders and its metabolic co-morbidities. The overall objective is to identify, prioritize and evaluate multi-modal blood and neuroimaging markers with diagnostic potential for prediction and monitoring of psychot ...
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 13

 TERMINÉ 

Direct Ethanol from MicroAlgae (DEMA)

Date du début: 1 déc. 2012, Date de fin: 31 mai 2017,

"The DEMA Consortium will develop, demonstrate and licence a complete economically competitive technology for the direct production of bioethanol from microalgae with low-cost scalable photobioreactors by 2016. Initial proof-of-concept results show via Life Cycle Assessments (LCA) and economic balance that it is feasible to use microalgae to produce bioethanol for less than € 0.40 per litre. The c ...
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 10

 TERMINÉ 

Biological Foundation for the Safety Classification of Engineered Nanomaterials (ENM): Systems Biology Approaches to Understand Interactions of ENM with Living Organisms and the Environment (NANOSOLUTIONS)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

The main objective of this research proposal is to identify and elaborate those characteristics of ENM that determine their biological hazard potential. This potential includes the ability of ENM to induce damage at the cellular, tissue, or organism levels by interacting with cellular structures leading to impairment of key cellular functions. These adverse effects may be mediated by ENM-induced a ...
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 40

 TERMINÉ 

Interferon-beta treatment of acute respiratory distress syndrome (ARDS) (TRAUMAKINE)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2016,

This application aims at a European marketing application for an orphan indication of the biopharmaceutical interferon-beta (IFN-beta) (EU3/07/505), to treat acute lunge injury (ALI) and acute respiratory distress syndrome (ARDS). Despite the much improved mechanical ventilation techniques and improved supportive therapies, ARDS kills 35-40 % of the 175.000 annual European patients. This condition ...
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 5

 TERMINÉ 

Innovative Radiochemistry to Advance Molecular Imaging (RADIOMI)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

The RADIOMI Initial Training Network (ITN) has the goal of providing training in a superbly suited academic and industrial environment uniquely equipped to conduct a scientific research program that addresses one of the key aspects of functional imaging, the underpinning radiochemistry essential for preparation of radiotracers currently difficult or not possible to access. This will be exploited f ...
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 9

 TERMINÉ 

Design & Engineering of Photosynthetic Communities for Industrial Cultivation (PHOTO.COMM)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

The generation of young biotechnologists is of paramount importance for Europe´s future. PHOTO.COMM will train primarily early stage researchers who have demonstrated high ambitions and talents in a unique platform based on emerging technology and science that would shape the forefront of future European biotechnology. PHOTO.COMM involves the utilization of microalgae for the conversion of carbon ...
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 11

 TERMINÉ 

Cancer Associated Fibroblasts (CAF) Function in Tumor Expansion and Invasion (CAFFEIN)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"Aim of the CAFFEIN network is to provide 10 early stage researchers (ESRs) and 2 exprerienced researchers (ERs) with excellent training in an industry relevant area of cancer research, complementary skills required for pharmaceutical industry, and knowledge in setting up biomedical start-up companies. To this end, the network comprises two full industrial partners: the established pharmaceutical ...
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 11

 TERMINÉ 

A new therapeutic antibody with a personalised medicine approach in cardiovascular disease (CARDIMMUN)

Date du début: 1 août 2013, Date de fin: 31 juil. 2016,

"The project, CARDIMMUN, aims to pursue development of the scientific findings from the FP6 project CVDImmune. Based on our patented discovery, that low levels of anti-PC (phosphorylcholine) indicate risk for future development of cardiovascular disease, we have developed both a diagnostic test (a marker to identify cardiovascular disease patients that are at high risk of secondary events) and a c ...
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 5

 TERMINÉ 

Direct photobiological conversion of solar energy to volatile transport fuels (PHOTOBIOFUEL)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

The aim is to integrate photosynthetic solar energy conversion and synthesis of volatile engine-ready transport fuel in a single photobiological process. The focus is placed on the construction of phototrophic model systems for synthesis of the short-chain alkane propane (C3H8). Propane can be used in existing engines without further chemical conversion and can be easily recovered from the product ...
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 3

 TERMINÉ 

Advanced Radio Astronomy in Europe (RADIONET3)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

RadioNet is an I3 that coordinates all of Europe’s leading radio astronomy facilities in an integrated cooperation to achieve transformational improvement in the quality and quantity of the scientific research of European astronomers. RadioNet3 includes 27 partners operating world-class radio telescopes and/or performing cutting-edge R&D in a wide range of technology fields important for radio ast ...
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 29

 TERMINÉ 

Infrastructure for Systems Biology - Europe (ISBE)

Date du début: 1 août 2012, Date de fin: 31 juil. 2015,

...the needs of European systems biology, in terms of development, applications and training. In order to address this requirement, we are proposing a distributed, interconnected infrastructure which primarily comprises three types of centres: Data Integration Centres (DICs), and systems biology dedicated Data Generation Centres (DGCs), and Data Stewardship Centres (DSCs). DICs are research centres t ...
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