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 EN COURS 
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 TERMINÉ 
... ablished interaction of tumor cells with their surrounding microenvironment. Failure of a microscopic tumor, either primary, recurrent or metastatic, to complete one or more of these early stages may lead to delayed clinical manifestation of the cancer and a state of stable non-progressing disease. Micrometastasis, dormant tumors, and residual tumor cells contribute to the occurrence of relapse, a ...
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 1

 TERMINÉ 

Targeting Glioblastoma Reprogrammed Stem Cells (Tumor Reprogramming)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2019,

Glioblastoma multiforme (GBM) is both the most common and lethal primary malignant brain tumor. In the last century we have accumulated tremendous amounts of data on this type of cancer, but we have achieved very little improvement in its treatment. Despite decades of concerted effort and advances in surgery, radiation and chemotherapy, the median survival is 15 months. The inadequate progress in ...
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 1

 TERMINÉ 

RNA-Mediated Inheritance of Acquired Traits (TransgenerationalRNA)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Inheritance of acquired traits is a topic of long-standing interest and controversy. While some of the classic Lamarckian ideas have been dismissed, more recent observations suggest that certain characteristics acquired by an animal during its lifetime might be transmitted to the next generations. Recently I described, for the first time in animals, a biological context in which acquired traits ar ...
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 1

 TERMINÉ 

Ploidy change as a rapid mechanism of adaptation (RAPLODAPT)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

... earch program will integrate = approaches at the genetic, genomic, molecular, cellular and population levels and includes computational approaches to model evolutionary processes.The project will lead to unparalleled advances in tools for the research community, and important insights concerning how diversity arises rapidly. It will assist in efforts to design diagnostic and therapeutic strategies ...
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 1

 TERMINÉ 

High-Dimensional Phenomena and Convexity (DIMENSION)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2018,

... ry, such as the concentration of measure, which seem to compensate for the vast amount of different possibilities. Convexity is one of the ways in which to harness these motifs and thereby formulate clean, non-trivial theorems. The scientific goals of the project are to develop new methods for the study of convexity in high dimensions beyond the concentration of measure, to explore emerging connec ...
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 2

 TERMINÉ 
... echanism of action. Studying the interactions between bacteria and phages should highlight the evolutionary role of the system and its consequences for shaping ecological systems. These insights will lead to novel ways of exploiting the system to improve molecular biology tools, to protect fermenting bacteria from phage spoilage, to equip phages with anti-CRISPR warfare to fight bacteria, and to p ...
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 1

 TERMINÉ 

Rapid parsimonious modelling (RAPID)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

... ured sparse and low rank representations of data, has been shown as a tremendously successful model in numerous domains of science, including signal and image processing, computer vision, and machine learning problems. Despite this success, parsimonious representation pursuit approaches practiced today face serious limitations stemming from their reliance on iterative optimization. In this project ...
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 2

 TERMINÉ 

Algorithmic Mechanism Design: Beyond Truthful Mechanisms (AMD)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

... for markets of tens of billions of dollars in revenue, such as online advertising, or sales of wireless frequencies.The timing of this project is ideal, as the AMD field is now sufficiently mature to lead to a breakthrough and at the same time young enough to be receptive to new approaches and themes."
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 1

 TERMINÉ 

Quantum Field Theory at Finite Coupling (QFT@FC)

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2018,

"The constituents of atoms in nature are quarks and gluons. The quarks source a color flux between them that result in the strong nuclear force, confining them together. The same gluonic color flux controls almost any strong coupling dynamics in the theory of gluons, namely quantum chromodynamics (QCD). For instance, it arises in parts in the computation of scattering amplitudes of these particles ...
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 1

 TERMINÉ 
Next generation sequencing (NGS) is revolutionizing all fields of biological research but it fails to extract the full range of information associated with genetic material and is lacking in its ability to resolve variations between genomes. The high degree of genome variation exhibited both on the population level as well as between genetically “identical” cells (even in the same organ) makes gen ...
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 1

 TERMINÉ 
"The proposed research belongs to symplectic topology, a rapidly developingfield of mathematics which originally appeared as a geometric tool for problems of classical mechanics. Since the 1980ies, new powerful methods such as theory of pseudo-holomorphic curves, Morse-Floer theory on loop spaces, symplectic field theory and mirror symmetry changed the face of the field and put it at the crossroad ...
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 1

 TERMINÉ 

Studying Pathogen Phage Host Interactions (PathoPhageHost)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

The DNA uptake competence system of the intracellular bacterial pathogen Listeria monocytogenes was considered non-functional. There are no known conditions for DNA transformation and the competence master activator gene, comK, is interrupted by a temperate (lysogenic) prophage. We have shown recently that the L. monocytogenes competence system is required during infection to promote bacterial esc ...
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 1

 TERMINÉ 
"Glucose homeostasis relies on tightly controlled release of insulin by pancreatic beta-cells. Diabetes, characterized by increased blood glucose levels, is a chronic disease now reaching epidemic proportions. The most common form of this disease is Type 2 diabetes (T2D), which was previously regarded as a disease of insulin resistance. However, work over the past decadehad shifted this paradigm b ...
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 1

 TERMINÉ 

Optimization Problems on Geometric Range Spaces (Opt-geom-rs)

Date du début: 1 sept. 2014, Date de fin: 31 août 2018,

... of the problems presented in this proposal. On the applied front, this problems have applications to other disciplines as sensor networking, computer graphics, geographic information systems, machine learning and more. In fact, the PI is collaborating with researchers from sensor networking and learning where she applies such mathematical tools in order to solve problems from the real world.
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 1

 TERMINÉ 

Markers and mechanisms of sensory disconnection (StateDependentProces)

Date du début: 1 juin 2014, Date de fin: 31 mai 2018,

... s of sensory disconnection and determine to what extent sleep and cognitive factors bring about similar disconnection. I hypothesize that sensory disconnection is a result of neuromodulatory changes, leading to a functional decoupling between early sensory cortex and higher order cortices. Specifically, reduced locus coeruleus-norepinephrine (LC-NE) activity may be a key mechanism, possibly affect ...
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 1

 TERMINÉ 
AFLoNext is a four year EC L2 project with the objective of proving and maturing highly promising flow control technologies for novel aircraft configurations to achieve a quantum leap in improving aircraft’s performance and thus reducing the environmental footprint. The project consortium is composed by forty European partners from fifteen countries. The work has been broken down into seven work p ...
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 41

 TERMINÉ 
... ilouts – have dominated much the public debate and divided electorates over the desired response to the crisis. What explains variation in voters' position on these contentious policies? Are the cleavages among the electorate a reflection of the distributive impacts of the policies, an outcome of divergent beliefs among individuals about the sources and consequences of the crisis, or perhaps a ref ...
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 1

 TERMINÉ 

Verifying and Synthesizing Software Compositions (VSSC)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

... nd use a variety of concrete, interlinked data structures. The current situation, in which programmers either directly write these data structures themselves or use a standard data structure library, leads to two problems:1:The particular choice of data representation is based on an expectation of what the most common workloads will be; that is, the programmer has already made cost-benefit trade-o ...
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 2

 TERMINÉ 

Mob Data Sourcing (MoDaS)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2018,

... such information. This encompasses a formal model capturing all the diverse facets of crowd-sourced data. This also means developing the necessary reasoning capabilities for managing data sourcing, cleaning, verification, integration, sharing, querying and updating, in a dynamic Web environment. This technological breakthrough will open the way for developing new and otherwise unattainable univer ...
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 1

 TERMINÉ 

Coherent control and molecular dynamics in the era of terahertz (COSMODET)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,

"Intense electromagnetic fields in the Terahertz (THz, 10^-12 Hz) frequency range have recently become tabletop available. In this proposal I offer to advance this unique range of frequencies into the world of gas phase coherent control and molecular dynamics. THz fields interact with molecules via their permanent electric dipoles, and induce molecular orientation, thus providing a new molecular h ...
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 1

 TERMINÉ 

Interactive Communications in Noisy Channels (IntComm)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,

... are to develop a formal mathematical theory of noisy interaction, and to apply it towards the design of efficient interactive communication protocols. A breakthrough in this line of research could lead to a paradigm shift that would revolutionize communication systems methodologies, facilitating cheaper, power-saving, more robust designs."
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 1

 TERMINÉ 
Should sovereign governments be accountable only to their citizens or should they also consider the welfare of foreign stakeholders? Traditional doctrines on state sovereignty and citizenship offer a generally negative answer: Absent a specific, voluntarily accepted, treaty-based commitment, sovereign governments usually have no obligation to weigh foreigners’ interests. This traditional vision co ...
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 1

 TERMINÉ 
... en reached the attention of the general public. An ignored cause is the inappropriate statistical treatment of two statistical problems: (1) selective inference, manifested in selecting few promising leads following the statistical analysis of the potential many, where ignoring the selection process on estimates, confidence intervals and observed significance; (2) using too optimistic a yardstick ...
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 1

 TERMINÉ 
Children with Autism Spectrum Disorders (ASD) experience a complex range of social, emotional, and behavioural difficulties that present significant, ongoing concerns for parents. A well-accepted sequel of children's ASD is increased parenting stress. Despite consistent evidence demonstrating significant ongoing associations between behavioural difficulties among children with ASD and parenting st ...
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 1

 TERMINÉ 
... neurons trafficking mechanisms mediated by motor proteins are used to achieve precise signal targeting. Alterations in the trafficking machinery may results in incorrect signaling, that in some cases leads to neurodegeneration. An example for such phenomenon may be found in Amyotrophic Lateral Sclerosis (ALS). ALS is a motor neuron disease characterized by a non-cell autonomous neurodegeneration p ...
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 1

 TERMINÉ 

Arithmetic and Quantum Chaos (ARITHQUANTUMCHAOS)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

Quantum Chaos is an emerging discipline which is crossing over from Physics into Pure Mathematics. The recent crossover is driven in part by a connection with Number Theory. This project explores several aspects of this interrelationship and is composed of a number of sub-projects. The sub-projects deal with: statistics of energy levels and wave functions of pseudo-integrable systems, a hitherto u ...
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 1

 TERMINÉ 

European Facility for Airborne Research in Environmental and Geo-sciences (EUFAR2)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

EUFAR aims at providing researchers with Open Access to the airborne facilities the most suited to their needs. EUFAR thus allocates Transnational Access to 21 installations, develops a culture of co-operation between scientists and operators, and organizes training courses to attract young scientists to airborne research. To improve the quality of the service, EUFAR supports the experts on airbor ...
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 24

 TERMINÉ 
The overall goal with INFECT is to advance our understanding of the pathophysiological mechanisms, prognosis, and diagnosis of the multifactorial highly lethal NSTIs. The fulminant course of NSTIs (in the order of hours) demands immediate diagnosis and adequate interventions in order to salvage lives and limbs. However, diagnosis and management are difficult due to heterogeneity in clinical presen ...
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 16

 TERMINÉ 

Carbon-nanotube-based terahertz-to-optics rectenna (CANTOR)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

"The efficiency of traditional semiconductor solar cells is subject to a fundamental limitation, known as the Shockley-Queisser recombination limit, and is found to be near 30 per cent. The invention in the early eighties of solar cell rectifying antennas (rectennas) - a combination of an optical antenna and a rectifying diode to efficiently absorb the incident solar radiation and directly conver ...
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 2

 TERMINÉ 

Harnessing Oxygenic Photosynthesis for Sustainable Energy Production (HOPSEP)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,

Oxygenic photosynthesis, that takes place in cyanobacteria algae and plants, provides most of the food and fuel on earth. The light stage of this process is driven by two photosystems. Photosystem II (PSII) that oxidizes water to O2 and 4 H+ and photosystem I (PSI) which in the light provides the most negative redox potential in nature that can drive numerous reactions including CO2 assimilation a ...
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 1

 TERMINÉ 

The Gamma Ray Burst – Supernova Connection and Shock Breakout Physics (GRB-SN)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,

... However, we do not know how a single stellar collapse can produce these two apparently very different explosions. The GRB-SN connection raises many questions, but it also offers new opportunities to learn on the two types of explosions.The focus of the proposed research is on the connection between CCSNe and GRBs, and on the physics of shock breakout. As I explain in this proposal, shock breakou ...
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 1

 TERMINÉ 
"The main S&T objective of CATSENSE is to design novel high performance catalysts and biosensors by a new interactive approach combining i. the production of mono and bi-metallic gas-phase clusters of controlled homogeneity, ii. the extensive characterisation of their morphology, structure (ex and in situ) and optical properties, iii. theoretical modelling and screening, and iv. catalytic and bios ...
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 7

 TERMINÉ 
... eatment of infections caused by MDR pathogens that impose a major burden of disease in Europe and the rest of the world by selecting 5 off-patent-antibiotics that are increasingly being used without clear evidence with respect to their effectiveness, duration of therapy and issues of EDR. In the first trial the efficacy of colistin alone is compared to colistin plus imipenem for severe infections ...
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 19

 TERMINÉ 

Low-toxic cost-efficient environment-friendly antifouling materials (BYEFOULING)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2017,

... all along their life cycle. A proof-of-concept for the most promising candidates will be developed and demonstrators will be produced and tested on fields.BYEFOULING will combine a multidisciplinary leading research team from 11 European countries, which are already acting worldwide in the scientific community, with highly relevant and skilled technological partners, to build a consortium able to ...
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 19

 TERMINÉ 
Our proposal is based on the idea that real-time functional neuroimaging can be used to train patients to regulate their own brain activity via neurofeedback training and thus modulate the brain networks of mental disorder, restore function, improve symptoms and promote resilience. We have brought together the core groups that have been instrumental in the development of methods for real-time func ...
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 12

 TERMINÉ 
MEDCHANGe focuses on the analysis of the relationships between global networks (Internet), flows (virtual and spatial mobilities of individuals, information i.e. migration also in light of gender issues such those of Moroccon female migrants; climate change migrants; tourism and heritage valorisation flows) and geographical localities in terms of local development and marginalisation/segregation. ...
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 6

 TERMINÉ 
A persistent challenge in unravelling mechanisms that regulate memory function is how to bridge the gap between inter-molecular dynamics of single proteins, activity of individual synapses and emerging properties of neuronal circuits. The prototype condition of disintegrating neuronal circuits is Alzheimer’s Disease (AD). Since the early time of Alois Alzheimer at the turn of the 20th century, sci ...
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 1

 TERMINÉ 
... ally respected centre, providing robust, reliable and timely delivery of hiPSCs; ensures the biorepository only houses quality assured hiPSC lines; and reduces unwanted variability in assays. We have leading experts in hiPSC differentiation, providing protocols with over 99% efficiency in producing cortical excitatory neurons and cardiomyocytes, which following up-scaling will meet demands of high ...
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 38

 TERMINÉ 

The Affective Role of the Teachers in the Information Age Classroom (ARTIAC)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

"The suggested project (ARTIAC) will be carried out under the interdisciplinary field of the Learning Sciences, and will use various research methodologies, including state-of-the-art Learning Analytics and Educational Data Mining approaches. Its main purpose is to empirically study the changing role of the teacher in an era where software used in class might be capable of recognizing not only a p ...
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 1