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 TERMINÉ 
"This collaborative project will develop a European methodology to assess the implementation of research evidence into practice (the European Implementation Score (EIS)), in primary, secondary and specialist care from the perspectives of different target groups (users and carers, voluntary organisations, range of health and social care professionals and health policy makers). The EIS will measur ...
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 8

 TERMINÉ 

Persisting Transgenesis (PERSIST)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2013,

"For many disabling or fatal diseases, there is pre-clinical or clinical evidence of the potential therapeutic efficacy of gene therapy and, yet, the limitations of current gene transfer technologies have prevented success or even caused serious adverse events leading to termination of trials. PERSIST will explore the use of highly innovative gene-modifying and delivery technologies and capitalize ...
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 29

 TERMINÉ 
The research program aims to understand the dynamics of the structural and functional organization of the visual cortex and the implications for amblyopia ('lazy eye', the most prevalent visual disorder among young people). We will study these fundamental issues from the molecular level all the way to the network level. To achieve this, members of the consortium have - for the first time - establi ...
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 8

 TERMINÉ 

Restorative Plasticity At Corticostriatal Excitatory Synapses (REPLACES)

Date du début: 1 nov. 2008, Date de fin: 30 avr. 2013,

"Long-lasting, activity-dependent synaptic changes are thought to underlie the ability of the brain to translate experiences into memories and seem to represent the cellular model underlying learning and memory processes. Alteration of brain plasticity may lead to the motor and cognitive disturbances observed in neurodegenerative diseases. Therapeutic approaches targeting synaptic plasticity could ...
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 12

 TERMINÉ 

A closed-loop neural prosthesis for dizziness suppression (CLONS)

Date du début: 1 janv. 2009, Date de fin: 31 mars 2013,

The main goal of the CLONS project is to develop suitable technological solutions to increase the quality of life of people affected by vestibular disorders. Toward this aim, an innovative closed-loop sensory neural prosthesis will be developed and tested in animal models and in selected humans. This neural prosthesis will be able to restore vestibular information by stimulating the semicircular c ...
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 8

 TERMINÉ 

Pattern Analysis, Statistical Modelling and Computational Learning 2 (PASCAL2)

Date du début: 1 mars 2008, Date de fin: 28 févr. 2013,

Description Creating new technologies in the area of Machine Learning through networking and technology transfer PASCAL2 builds on the PASCAL Network of Excellence that has created a distributed institute pioneering principled methods of pattern analysis, statistical modelling, and computational l ...
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 29

 TERMINÉ 

Definition of a genetic network involved in congenital heart disease (CardioGeNet)

Date du début: 1 mars 2009, Date de fin: 28 févr. 2013,

This application focuses on transcriptional networks that govern the development of a heart region commonly affected by congenital heart disease (CHD). The major goal is to provide the clinical and basic science research communities with a validated list of interconnected genes required for normal heart development. To achieve this goal, we have recruited 6 European groups of scientists strongly ...
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 8

 TERMINÉ 

AiR Guidance and Surveillance 3D (ARGUS 3D)

Date du début: 1 déc. 2009, Date de fin: 28 févr. 2013,

"The project aims to improve the detection of manned and unmanned platforms by exploiting the treatment of more accurate information of cooperative as well as non-cooperative flying objects, in order to identify potentially threats. The scope will be reached by managing the 3D position data in region including extended border lines and large areas, 24 hours a day and in all weather conditions, der ...
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 13

 TERMINÉ 
"The prevalence of overweight amongst European children and adolescents has risen at an alarming rate in the past decades, with major repercussions for their health in the short and long term. Existing prevention programmes to combat the epidemic either highlight a public health approach (employing incentive schemes such as taxing of foods) or an individual-educational approach to encourage young ...
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 9

 TERMINÉ 

Genetic prostate cancer variants as biomarkers of disease progression (PROMARK)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2012,

Prostate cancer is the most common cancer in males in Europe, causing over 87,000 deaths in 2006. Early diagnosis and treatment are key factors in determining survival but screening methods based on the commonly-used PSA blood test have low specificity and result in excessive treatment of localized lesions that might never progress to symptomatic cancer. Biomarkers that help determine which of the ...
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 6

 TERMINÉ 

European Planetology Network Research Infrastructure (EuroPlaNeT RI)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

The Europlanet RI project will provide the European planetary science community with a unique research infrastructure, combining access to a suite of state of the art facilities while fostering their joint development and integration in terms of capacity and performance. This research infrastructure will include access to laboratory and field site facilities, advanced modelling, simulation and dat ...
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 28

 TERMINÉ 
"Neurodegenerative diseases all cause damage to the circuitry of the nervous system, with loss of connections, axons and neurons. The loss can be gradual, as in Alzheimer’s disease, rapid as in stroke, or intermediate as in the delayed neuronal loss after stroke. Following damage, the nervous system is able partially to compensate through the formation of alternative connections and pathways, a pr ...
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 16

 TERMINÉ 

Probabilistic Framework for Onboard Fire-Safety (FIREPROOF)

Date du début: 1 juin 2009, Date de fin: 31 oct. 2012,

"The traditional fire safety regulations that apply to ship design have been widely described as inadequate in two ways. Firstly they do impose unnecessary and inapplicable constraints on novel designs. Secondly novel designs can have features that do not satisfy the premise of existing rules, thereby setting them free from fire safety rules by default, often leading to unsafe designs. In or ...
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 13

 TERMINÉ 
The proposed research project will study the interactions between knowledge, economic growth and social wellbeing in Europe. It focuses on knowledge-intensive entrepreneurship as a necessary mechanism and an agent of change mediating between the creation of knowledge and its transformation into economic activity. Knowledge-intensive entrepreneurship is perceived herein as a core interface between ...
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 22

 TERMINÉ 
"MOLPARK aims to define the basic cellular and molecular mechanisms underlying the generation, differentiation, survival and connectivity of nigrostriatal dopaminergic neurons and translate this knowledge into radically new therapeutic strategies for Parkinson's disease (PD). MOLPARK brings together two industrial partners and 6 world-renowned academic groups with a uniquely advantageous knowledge ...
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 7

 TERMINÉ 

Personal Intelligent City Accessible Vehicle System (PICAV)

Date du début: 1 août 2009, Date de fin: 30 sept. 2012,

"The proposal presents a new mobility concept for passengers ensuring accessibility for all in urban pedestrian environments. The concept addresses a new Personal Intelligent City Accessible Vehicle (PICAV) and a new transport system that integrates a fleet of PICAV units. The transport system will ensure accessibility for everybody and some of its features are specifically designed for people who ...
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 7

 TERMINÉ 

Ultrafast control of quantum systems by strong laser fields (FASTQUAST)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

"The objective of this project is to set up an Initial Training Network on advanced techniques for ultrafast manipulation of atoms and molecules by strong femtosecond laser pulses. The project comprises a diverse range of applications of strong-field coherent control to ultrafast spectroscopy and microscopy; nuclear and electron wavepacket dynamics; alignment of molecules with applications to coll ...
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 13

 TERMINÉ 

Initial Training Network: Lateralized Attention Networks (ITN-LAN)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

"The proposed Initial Training Network for Lateralized Attention Networks (ITN-LAN) brings together 6 research teams with established international reputations and, more importantly, is founded on well established collaborations. The long-term scientific objectives of the proposed ITN-LAN are: (1) To validate and standardize a behavioural battery for assessing the attentional networks of the two ...
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 7

 TERMINÉ 

Lactase persistence and the Cultural History of Europe (LeCHE)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

The ideal training for future researchers in Europe, draws together leading groups in the world, state-of-the-art methods and a clearly focused, important and emotive questions with widespread repercussions, and integrates them using sophisticated tools and training devices; welcome to LeCHE. This large (14 researcher, 24 participant) training network explores the origin and impact of dairying Eur ...
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 13

 TERMINÉ 
"This proposal offers to combine X-ray CT (XCT) and Fluorescence Molecular Tomography (FMT) into a hybrid, quantitative system and method. The project builds on state-of the-art knowledge that only recently became available in different European states as represented by the partners herein. In return it delivers the first such hybrid system worldwide. The system will operate by 1) co-registering ...
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 8

 TERMINÉ 

Neurotransmitter Cys-loop receptors: structure, function and disease (NeuroCypres)

Date du début: 1 févr. 2008, Date de fin: 31 juil. 2012,

Cys-loop receptors (CLRs) form a superfamily of structurally related neurotransmitter-gated ion channels, comprising nicotinic acetylcholine, glycine, GABA-A/C and serotonin (5HT3) receptors, crucial to function of the peripheral and central nervous system. CLRs cover a wide spectrum of functions, ranging from muscle contraction to cognitive functions. CLR (mal)function is linked to various disord ...
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 24

 TERMINÉ 
"PENTA-LABNET(PL) is a coordination action aimed at improving the range of products and clinical use of antiretrovirals(ARVs) in HIV-infected children in resource-rich and resource-limited countries. This will be achieved through building capacity of laboratories to undertake co-ordinated studies on pharmacokinetics, pharmacodynamics and pharmacogenetics of new formulations and dosing and studies ...
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 12

 TERMINÉ 

Combating incontinence, from basic science to clinical practice (INComb)

Date du début: 1 déc. 2008, Date de fin: 31 mai 2012,

Incontinence affects almost 66 million people in the European Union. The Over Active Bladder (OAB) symptom complex is one of the major causes for incontinence, with a large number of affected persons and immense associated health care costs. The causes for the over active bladder contractions, underlying the urinary urgency of OAB are unknown, and current treatments are only partially effective. T ...
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 10

 TERMINÉ 
Cellular protection against oxidative damage is relevant to ageing and numerous complex diseases. We plan to use fission yeast as a model organism to gain a systems-level understanding of the oxidative stress response and obtain insights into the interplay of variable genotype, phenotype, and environment. To this end, the four participants will pursue a range of multi-disciplinary and complementin ...
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 4

 TERMINÉ 
The proposal aims at the development and clinical validation of advanced non-invasive optical methodologies for in-vivo diagnosis, monitoring, and prognosis of major neurological diseases (stroke, epilepsy, ischemia), based on diffuse optical imaging by pulsed near infrared light. Established diagnostic imaging modalities (e.g. X-ray Computed Tomography, Magnetic Resonance Imaging, Positron Emissi ...
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 14

 TERMINÉ 

Strategy for the preservation of plastic artefacts in museum collections (Popart)

Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,

During the twentieth century artists have used plastics and synthetics to create important pieces that are recognized nowadays as masterpieces. Unfortunately some plastics are degrading faster than had been expected and their preservation constitutes a challenge. Their is a lack of knowledge and agreement about the way we can exhibit, clean and store them in order to lower their deterioration spee ...
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 12

 TERMINÉ 
The coordination project EuroVisionNet aims to link the research activities and policies of the European vision research community and to overcome the national fragmentation, therewith intends to become an essential “instrument” for vision research in the 21st century. To reach this goal the following 4 objectives will be addressed: (1) scientific integration of European vision research; (2) colla ...
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 10

 TERMINÉ 
Most buildings of cultural/historical interest are located in urban environments. They undergo a number of different external forcings, which need to be addressed separately. It is important to consider local-scale variations of the urban environment, such as changes in pollutants, temperature field, relative humidity cycles, wind field, urban heat island effect etc. The most important challenge ...
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 10

 TERMINÉ 
The call 4.2.2-1 “organic materials for electronics and photonics” is based on the observation that the limited availability of high-performance multi-functional materials is a roadblock to further industrial progress. To address the wide scope of the call, we have identified specific materials bottlenecks to the fields of electronics and photonics. They constitute the focal points of our project. ...
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 31

 TERMINÉ 

European Genetic Disease Diagnostics (EURO-GENE-SCAN)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2011,

"Molecular techniques have become more efficient, increasingly precise and much cheaper, resulting in an unprecedented discovery rate of inherited disease genes. In areas such as primary immunodeficiencies (PID), muscle disorders, growth deficiencies, hearing/vision impairments and metabolic diseases, very large numbers of different genes have been found to carry mutations in diseases with heterog ...
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 5

 TERMINÉ 
"Clostridium diffficile is currently wreaking havoc within European health systems due to the emergence of hyper virulent strains, responsible for more severe disease, higher relapse rates, increased mortality and greater resistance to antibiotics. Its impact in healthcare settings is considerable, in terms of morbidity, mortality and financial cost However, the physiological basis of pathogenesis ...
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 7

 TERMINÉ 

GENE THERAPY FOR INHERITED SEVERE PHOTORECEPTOR DISEASES (AAVEYE)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2011,

"The retina represents the visual sensory receptor of the nervous system (CNS). Inherited diseases like Retintitis Pigmentosa (RP) and Leber Congenital Amaurosis (LCA), for which no therapies are available, are due to mutations in genes preferentially expressed in the photoreceptor cells of the retina. Vectors derived from the adeno-associated virus (AAV) efficiently transduce the retina of anima ...
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 4

 TERMINÉ 
Cancer is often characterized as a disease of signal transduction pathways, since it is frequently associated with inappropriate activation of such pathways. Indeed, new therapeutic approaches in cancer therapy, such as Herceptin, frequently target signaling pathway components to revert their pathophysiological aberrations. Most oncogenic pathways have been highly conserved throughout evolution wi ...
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 8

 TERMINÉ 
Disorders of Sex Development (DSD) constitute a group of rare to very rare mostly heritable disorders affecting the genito-urinary tract and in most instances also the endocrine-reproductive system. We hypothesize that stringent and stepwise analysis of cases with DSD will result in a systematic and reliable discovery of DSD-relevant biochemical, genetic and functional profiles, allowing for the d ...
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 14

 TERMINÉ 
Inherited Neuromuscular Diseases (NMD) form a large group of diseases including Limb-Girdle Muscular Dystrophies (LGMD), Congenital Muscular Dystrophies (CMD), Duchenne and Becker Muscular Dystrophies (DMD/BMD), or Charcot-Marie-Tooth disease (CMT). Within a given disease group genetic and clinical heterogeneity is the hallmark. The precise diagnostic of neuromuscular diseases thus requires extens ...
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 13

 TERMINÉ 
The TNF Receptor Associated Syndrome (TRAPS) is a rare disease of innate immunity, caused by mutations in TNFR1. It is characterised by recurrent bouts of fever and pain and mainly affects patients of European ancestry. The development of renal amyloidosis in up to 20% of cases makes it a potentially fatal disease. Corticosteroids and anti-TNF therapeutics have not been consistently effective in c ...
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 9

 TERMINÉ 
Scalability, reconfigurability, and security are three aspects of paramount importance in developing efficient, predictable and safe control architectures for large-scale networked industrial automation. CHAT is about developing core components (algorithms, protocols and procedures) of the next-generation of distributed control systems, able to tackle the supervision and control of larger and mor ...
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 9

 TERMINÉ 

Space coding in hippocampo-entorhinal neuronal assemblies (SPACEBRAIN)

Date du début: 1 févr. 2008, Date de fin: 31 juil. 2011,

"Despite impressive advances in almost every field of neuroscience, our insights into brain function remain largely confined to its building blocks at the microscopic level, and to phenomenological descriptions at the macroscopic level. Understanding how complex mental functions originate from electrical and chemical processes in brain cells requires a comprehensive and integrated multi-level anal ...
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 7

 TERMINÉ 

EST: The large aperture European Solar Telescope (EST)

Date du début: 1 févr. 2008, Date de fin: 31 juil. 2011,

"This is the project definition for the Conceptual Design Study of the large aperture European Solar Telescope (EST). EST is a pan-European project involving 29 partners from 14 different countries. A consortium EAST (European Association for Solar Telescopes) exists with the aim, among others, of undertaking the development of EST, to keep Europe in the frontier of Solar Physics in the world. EST ...
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 30

 TERMINÉ 

Policies to promote sustainable consumption patterns (POPP) (POPP)

Date du début: 1 août 2008, Date de fin: 31 juil. 2011,

"The project aims at increasing knowledge about the impact of sustainable consumption (SC) policies on consumption patterns and on sustainability. This objective will be achieved by the following steps: A conceptual model will be developed as a framework for the whole project. Embedded in a broader overview of general SC strategies and instruments, research will focus on the need areas of food and ...
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 7