16 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Activation of vasculature associated stem cells and muscle stem cells for the repair and maintenance of muscle tissue (Endostem)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,
We propose to develop new strategies to mobilize skeletal muscle tissue-associated stem cells as a tool for efficient tissue repair. This will be combined with exploring novel approaches that limit tissue damage, and will focus on agents that modify muscle and muscle vasculature progenitor cells. These molecules include nitric oxide associated with non-steroidal anti-inflammatory drugs, HMGB1, Cri ...
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22
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TERMINÉ
European Molecular Biology Laboratory Interdisciplinary Postdocs (EIPOD)
Date du début: 1 déc. 2009, Date de fin: 30 nov. 2014,
The European Molecular Biology Laboratory (EMBL) has a strong tradition in promoting interdisciplinary basic research in molecular biology. With 93 laboratories in eight Research Units at five facilities in four European countries, working on topics ranging from structural to organismal biology and from computational and biophysics to chemical biology, the EMBL is one of the top research instituti ...
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1
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TERMINÉ
Genotype-To-Phenotype Databases: A Holistic Solution (GEN2PHEN)
Date du début: 1 janv. 2008, Date de fin: 30 juin 2013,
"The GEN2PHEN project aims to unify human and model organism genetic variation databases towards increasingly holistic views into Genotype-To-Phenotype (G2P) data, and to link this system into other biomedical knowledge sources via genome browser functionality. The project will establish the technological building-blocks needed for the evolution of today’s diverse G2P databases into a future seaml ...
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23
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TERMINÉ
Infrastructure for Protein Production Platforms (PCUBE)
Date du début: 1 avr. 2009, Date de fin: 31 mars 2013,
"The most important prerequisite and challenge in structural biology research at the atomic level by any method is the availability of sufficiently large amounts of highly purified functional proteins due to the increasing size and complexity of target proteins or protein complexes to be analyzed. Heterologous expression in bacteria, yeast, insect, or mammalian cells combined with many attempts in ...
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3
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TERMINÉ
Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes (INFRAFRONTIER)
Date du début: 1 mars 2008, Date de fin: 31 déc. 2012,
Medically related Life Sciences use the mouse as a model system to understand the molecular basis of health and disease in humans (>95% similarity of genes in humans and mice). An essential task for Biomedical Sciences in the 21st century will be the functional analysis of mouse models for every gene in the mammalian genome. The major bottlenecks identified by the user community will be proper ...
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29
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TERMINÉ
Servicing the European Biomedical Research Community: Archiving and Dissemination of Mouse Models of Human Disease (EMMAservice)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,
The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:1) Develop a series of mutant alleles for every gene in the mouse genome2) Determine the phenotypic consequences of each mutation3) Identify mouse models for the complete d ...
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11
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TERMINÉ
European Network for Genetic and Genomic Epidemiology (ENGAGE)
Date du début: 1 janv. 2008, Date de fin: 31 déc. 2012,
"ENGAGE (European Network for Genetic and Genomic Epidemiology) has, as its central objective, the translation of the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large-scale genetic and phenotypic data already available from a sub ...
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26
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TERMINÉ
Lipid droplets as dynamic organelles of fat deposition and release: Translational research towards human disease (LipidomicNet)
Date du début: 1 mai 2008, Date de fin: 31 oct. 2012,
Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quan ...
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27
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TERMINÉ
Development of cardiomyocyte replacement strategy for the clinic (CARDIOCELL)
Date du début: 1 mai 2009, Date de fin: 31 oct. 2012,
"Heart failure as a result of myocardial infarction or ischemic heart disease is a major health problem in Europe. Currently the only long term solution is heart transplantation but one in three patients die while awaiting a match. Transplantation of an alternative cell source is extremely attractive but has so far met with very little success. Thus, skeletal muscle myoblasts led to recurrent arrh ...
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7
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TERMINÉ
Neurotransmitter Cys-loop receptors: structure, function and disease (NeuroCypres)
Date du début: 1 févr. 2008, Date de fin: 31 juil. 2012,
Cys-loop receptors (CLRs) form a superfamily of structurally related neurotransmitter-gated ion channels, comprising nicotinic acetylcholine, glycine, GABA-A/C and serotonin (5HT3) receptors, crucial to function of the peripheral and central nervous system. CLRs cover a wide spectrum of functions, ranging from muscle contraction to cognitive functions. CLR (mal)function is linked to various disord ...
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24
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TERMINÉ
Metagenomics of the Human Intestinal Tract (MetaHIT)
Date du début: 1 janv. 2008, Date de fin: 30 juin 2012,
A detailed understanding of human biology will require not only knowledge of the human genome but also of the human metagenome, defined here as the ensemble of the genomes of human-associated microorganisms. Our proposal focuses on the microorganisms of the gut, which are particularly abundant and complex and have an important role for human health and well-being. We shall implement and integrate ...
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16
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TERMINÉ
"Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology, data mining, mathematical modelling, biostatistics, systems engineering and molecular medicine" (APO-SYS)
Date du début: 1 févr. 2008, Date de fin: 31 janv. 2012,
"A Europe-wide consortium of experimental biologists, biomathematicians, biostatisticians, computer scientists and clinical scientists will team up to approach cell death pathways in health and disease, placing particular emphasis on cancer and AIDS. The consortium will create a unique database integrating existing and accumulating knowledge on lethal signal transduction pathways leading to apopto ...
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24
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TERMINÉ
Coordination of resources for conditional expression of mutated mouse alleles (CREATE)
Date du début: 1 nov. 2008, Date de fin: 31 oct. 2011,
"This proposal describes CREATE, an internationally based Coordination Action directly addressing a large scale data gathering activity for systematic conditional mouse mutagenesis. Advances in the sophisticated manipulation of the mouse genome has established the mouse as the premier organism for developing models of human disease. Internationally coordinated initiatives have established for the ...
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8
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TERMINÉ
Developmental Molecular Pathways in Drosophila as a Model for Human Cancer (CancerPathways)
Date du début: 1 mai 2008, Date de fin: 31 oct. 2011,
Cancer is often characterized as a disease of signal transduction pathways, since it is frequently associated with inappropriate activation of such pathways. Indeed, new therapeutic approaches in cancer therapy, such as Herceptin, frequently target signaling pathway components to revert their pathophysiological aberrations. Most oncogenic pathways have been highly conserved throughout evolution wi ...
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8
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TERMINÉ
IMproving Protein Annotation and Co-ordination through Technology (IMPACT)
Date du début: 1 janv. 2008, Date de fin: 30 juin 2011,
New DNA sequencing and metagenomics projects are increasing the flow of poorly annotated raw sequence data into public databases with limited annotation. At the same time, users are imposing increasing demands on databases to include functional and contextual information, and to facilitate linking to other databases. Recent advances in technologies for achieving this and enabling complex querying ...
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8
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TERMINÉ
Biobanking and Biomolecular Resources Research Infrastructure (BBMRI)
Date du début: 1 févr. 2008, Date de fin: 31 janv. 2011,
The Preparatory Phase for a pan-European Biobanking and Biomolecular Resources Research Infrastructure (BBMRI) will focus on technical, legal, governance, and financial issues to • prepare to construct BBMRI, building on existing biobanks, resources and technologies, specifically complemented with innovative components and properly embedded into European scientific, ethical, legal and societal fra ...
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