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9 projets européens trouvés

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 TERMINÉ 

AMAROUT-II EUROPE (AMAROUT-II)

Date du début: 1 oct. 2012, Date de fin: 31 déc. 2017,

AMAROUT-II is a fellowship programme designed to support transnationalmobility (incoming and reintegration) of experienced researchers, togive them the opportunity to deepen and widen their skills and toprovide them with attractive working conditions. Specifically, over 4years, AMAROUT-II will offer 152 fellowships to experiencedresearchers to develop their individual research projects within theI ...
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 1

 TERMINÉ 

Collaborative Oncological Gene-environment Study (COGS)

Date du début: 1 mai 2009, Date de fin: 31 janv. 2014,

The overarching goal of COGS is to identify individuals with an increased risk of breast, ovary and prostate cancer. Furthermore, we will evaluate the effect of inherited genetic variation on tumour characteristics and clinical outcome. We will do this through quantifying the role of genetic and environmental/lifestyle risk in the largest data set ever generated. In all, we will include over 200,0 ...
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 16

 TERMINÉ 
"Bladder cancer is a recurrent and very prevalent cancer and it generates the highest cost per patient in Europe. New genomic methods have allowed identifying new markers with potential clinical application. However, due to the use of single-marker assays and poor study design, none of these markers has made it to the clinic. FGFR3 and PIK3CA mutations, expression profiles, and microsatellite alte ...
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 8

 TERMINÉ 
Epidemiological and experimental evidence supports a link between chronic inflammation and cancer and indicates a role for inflammatory cells in the initiation, progression and metastasis of malignancy. The objective of the collaborative integrated project INFLA-CARE is to structure a European collective of scientific and technological excellence in the field of ‘Inflammation & Cancer’ which will ...
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 22

 TERMINÉ 

European Life-science Infrastructure for Biological Information (ELIXIR)

Date du début: 1 nov. 2007, Date de fin: 31 déc. 2012,

"The objective of the ELIXIR preparatory phase is to produce a memorandum or memoranda of understanding between organisations (government agencies, research councils, funding bodies and scientific organisations) within the member states, with the purpose of constructing a world class and globally positioned European infrastructure for the management and integration of information in the life scien ...
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 33

 TERMINÉ 
In clinical studies, proteomics and transcriptomics allow the comparison of samples from different patients and hold special promise for the discovery of novel biomarkers and the development of “personalized medicine” approaches. Yet, translating recent discoveries into daily medical practice takes time and despite intensified researchers’ interest and investments, the rate of introduction of nove ...
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 9

 TERMINÉ 
"Aberrant DNA methylation is the most common molecular lesion of the cancer cell. Neither gene mutation nor cytogenetic abnormalities are as common in human tumours as DNA methylation alterations. The stability of our genome and correct gene expression is maintained to a great extent thanks to a perfectly preestablished pattern of DNA methylation and histone modifications. In cancer this idealisti ...
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 7

 TERMINÉ 
Telomeres are DNA-nucleoprotein structures that protect the ends of human chromosomes through the formation of a ‘cap’ that prevents exonucleolytic degradation, inter- & intra-chromosomal fusion and subsequent chromosomal instability. Telomerase, the ribonucleoprotein enzyme that maintains linear chromosomal DNA ends by the addition of TTAGGG repeats, is completely repressed or present only at low ...
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 8

 TERMINÉ 

Genomic Instability in Cancer and Precancer (GENICA)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2010,

"Genomic instability is a characteristic of practically all human cancers. Recent results generated by members of this Consortium suggest that signs of genomic instability are evident from the very beginning of human cancer development, even in precancerous lesions. In these early lesions, the genomic instability affects primarily specific genomic loci, called common fragile sites. Because common ...
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 11