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 TERMINÉ 

“In Vivo Click PET Imaging Agents”: Improving clinical companion diagnostics (Click-It)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Companion diagnostics are crucial for drug development and disease management with regard to patient selection, therapy planning and monitoring. Nanomedicines such as antibodies have been proven to be optimal disease-targeting agents because they generally exhibit superior target uptake and retention. However, to date, nuclear imaging of nanomedicines has been limited to the use of long-lived isot ...
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 6

 TERMINÉ 

Liaison in Scientific Training for European auditory Neuroscience (LISTEN)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

This ITN will train 10 ESRs to meet the urgent need for translation of Auditory Neuroscience into commercial and pharmaceutical products to treat hearing disorders including tinnitus. Tinnitus is the debilitating perception of imaginary sound that is often associated with hearing loss. This Liaison in Scientific Training for European auditory Neuroscience (LISTEN) is a consortium of top hearing sc ...
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 9

 TERMINÉ 

Clinical development of a dendritic-cell vaccine therapy for acute myeloid leukaemia (AML-VACCiN)

Date du début: 1 janv. 2016, Date de fin: 31 mars 2020,

Eradicating minimal residual disease (MRD) in patients with acute myeloid leukaemia (AML) is an area of high unmet medical need. AML is a deadly rare disease that affects both children and adults. Approximately 45% of younger AML patients who are treated will be cured, and in older patients (>60 years of age), 85% will relapse and die within 2 years.Immunotherapy has great potential for treating M ...
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 12

 TERMINÉ 

European Nuclear Science and Application Research 2 (ENSAR2)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

ENSAR2 is the integrating activity for European nuclear scientists who are performing research in three of the major subfields defined by NuPECC: Nuclear Structure and Dynamics, Nuclear Astrophysics and Nuclear Physics Tools and Applications. It proposes an optimised ensemble of Networking (NAs), Joint Research (JRAs) and Transnational Access Activities (TAs), which will ensure qualitative and qua ...
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 31

 TERMINÉ 

TRANSPORT OF SOFT MATTER AT THE NANOSCALE (NANOTRANS)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

We propose a Multi-Partner ITN-ETN network on Transport of Soft Matter at the Nanoscale. The scientific topic, which is the focus of the proposal, is an emerging field of science and technology. Challenges such as design of environmentally friendly engineering materials or understanding the principles of biological organization crucially depend on fundamental understanding of transport of fluids a ...
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 10

 TERMINÉ 

QUantitative paleoEnvironments from SpeleoThems (QUEST)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Speleothems (cave deposits, e.g. stalagmites) represent unique terrestrial archives that allow for accurately dated, high-resolution (often annual), continuous and long (many millennia) climate reconstructions. Such records are vital for understanding how climate varies and how our environments respond on seasonal to millennial timescales. However, current speleothem studies can only make qualitat ...
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 4

 TERMINÉ 

Elucidating Pathways of Steatohepatitis (EPoS)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

Strongly associated with the epidemics of obesity and type 2 diabetes mellitus (T2DM) that are testing healthcare systems worldwide, Non-Alcoholic Fatty Liver Disease (NAFLD) is an increasingly common cause of advanced liver disease in the aging population of Europe. NAFLD is a spectrum of hepatic fat accumulation (steatosis); steatosis plus inflammation (non-alcoholic steatohepatitis, NASH); fibr ...
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 13

 TERMINÉ 

Complex RhEologies in Earth dynamics and industrial Processes (CREEP)

Date du début: 1 avr. 2015, Date de fin: 31 mars 2019,

The CREEP Innovative Training Network is a training and career development platform for early stage researchers (ESRs) in Geodynamics, Mineral Physics, Seismology, Fluid Mechanics, and Materials Sciences. It aims to structure the collaboration in research and doctoral training between 10 leading academic centers in Earth Sciences in Europe: the CNRS (FR), represented by Geosciences Montpellier and ...
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 8

 TERMINÉ 

PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood (PANCARELIFE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The ...
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 19

 TERMINÉ 

APERIM: Advanced bioinformatics platform for PERsonalised cancer IMmunotherapy (APERIM)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2018,

Cancer treatment platforms that involve the use of the adaptive immune system have demonstrated profound tumour regressions including complete cure. Importantly, technological advances in next-generation sequencing (NGS) allow for the first time the development of personalised cancer immunotherapies that target patient specific mutations. However, clinical application is currently hampered by spec ...
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 11

 TERMINÉ 

Lipid Signaling at the Glutamatergic Synapse: Involvement in Brain Network Function and Psychiatric Disorders (LiPsyD)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

We have recently reported on a novel mode of modulation of neuronal transmission at the glutamatergic junction. This signaling pathway involves lysophosphatidic acid (LPA) acting via presynaptic LPA2 receptors. This is in turn controlled by a molecule which we named plasticity related gene-1 (PRG-1, Bräuer et al., Nat Neurosci 2003) from the postsynaptic side (Trimbuch et al., Cell 2009). PRG-1 is ...
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 1

 TERMINÉ 

European Consortium for the Study of a Topical Treatment of iCRVO to prevent Neovascular Glaucoma (STRONG)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2018,

Neovascular glaucoma (NVG) is a very aggressive and rare type of glaucoma: yet, it contributes disproportionately to blindness from all eye diseases. NVG is also the second most common cause for the removal of the eye-ball across all eye diseases, usually because of intractable pain. The major cause of NVG is Ischaemic Central Retinal Vein Occlusion (CRVO) leading to neovascularisation, obstructio ...
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 9

 TERMINÉ 

NutrImmune: Nutrient-controlled molecular pathways instructing development and function of mucosa-associated innate lymphocytes (NUTRIMMUNE)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

The last decade has witnessed an explosion of research into the molecular networks ensuring maintenance of a mutualistic relationship between microbes and host cell networks at mucosal surfaces. Failure of such homeostatic or adaptive programs lead to susceptibility to intestinal infections or to chronic inflammation causing debilitating human diseases such as inflammatory bowel diseases or inflam ...
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 2

 TERMINÉ 

Rydberg Quantum Simulators (RYSQ)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2018,

Quantum Simulators provide new levels of understanding of equilibrium and out-of-equilibrium properties of many-body quantum systems, one of the most challenging problems in physics. The main objective of the RYSQ project is to use Rydberg atoms for quantum simulations, because their outstanding versatility will allow us to perform a great variety of useful quantum simulations, by exploiting diffe ...
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 16

 TERMINÉ 

Volcanic ash: field, laboratory and numerical investigations of processes during its lifecycle (VERTIGO)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

Explosive volcanic eruptions are an unavoidable natural hazard: Volcanic ash, the ejected lethal mixture of crystals, lava, glass and older rocks, is the most far-reaching threat. In April 2010, the ash cloud from Eyjafjall volcano in Iceland, a comparatively small event, paralysed large parts of Europe for up to one week in a manner unique in history. The impact was dramatic: several million pass ...
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 10

 TERMINÉ 

solving CHAllenges in Nuclear DAta (CHANDA)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2017,

"The CHANDA project main objective is to address the challenges in the field of nuclear data for nuclear applications and its acronym stands for solving CHAllenges in Nuclear DAtaThe project will prepare a proposal for an organization that will coordinate the nuclear data research program, and the infrastructures and capabilities of the EU Member States in a stable structure, well integrated with ...
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 35

 TERMINÉ 

Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine (NCRNAPAIN)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs (ncRNAs) regulate both immune and neuronal processes. Therefore, ncRNAPain proposes that ncRNAs are critically important master switches for chronic pain.ncRNAPain represents a multidisciplinary consortium of clinical partners, molecular and systems-level n ...
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 12

 TERMINÉ 

Planar Atomic and Molecular Scale devices (PAMS)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

The PAMS project will explore all scientific and technological aspects of the fabrication of planar atomic and sub-molecular scale electronic devices on surfaces of Si:H, Ge:H, AlN, CaCO3 (calcite) and CaF2 with atomic scale precision and reproducibility. The sub-nanoscale devices will be made by combining ultra-precise Scanning Tunnelling Microscopy (STM) and non-contact-Atomic Force Microscopy ( ...
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 8

 TERMINÉ 

Oral biopharmaceutics tools (ORBITO)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

The OrBiTo project will deliver novel methods and a framework for rational application of predictive biopharmaceutics tools for oral drug delivery. This will be achieved through novel propsective studies to define new methodlogies which will be validated using historical datasets from EFPIA partners. A combination of high quality in vitro or in silico characterizations of API and formulations will ...
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 28

 TERMINÉ 

Quantitative Imaging of Liver Fibrosis and Fibrogenesis (LiverFibrosisImaging)

Date du début: 1 août 2012, Date de fin: 31 juil. 2017,

Chronic liver disease can progress to cirrhosis, with death due to liver failure and cancer. Cirrhosis prevalence in the EU is 0.5%-1%. However, development of therapies that prevent progression to cirrhosis is hampered by the lack of a sensitive, non-invasive method to quantify fibrosis or fibrosis progression (fibrogenesis). Liver biopsy 1) is risky, 2) shows high sampling variability, and 3) is ...
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 3

 TERMINÉ 

Chronotherapeutic lifestyle intervention for diabetes and obesity to reset the circadian rhythm and improve cardiometabolic risk in the European working population (EURHYTHDIA)

Date du début: 1 oct. 2011, Date de fin: 30 juin 2017,

Modern lifestyle has dramatically changed the daily rhythms of life. Physical activity, diet and light exposure are no longer restricted to daytime hours, as technical and economical de-mands fuel the necessity to work outside usual working hours. Recent studies show that al-tered light exposure, shifted exercise patterns and untimely food intake following extended active periods into the night di ...
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 17

 TERMINÉ 

Open Project for the European Radiation Research Area (OPERRA)

Date du début: 1 juin 2013, Date de fin: 31 mai 2017,

"Within the OPERRA project, it is proposed that the MELODI Association, as a well-advanced network, takes the lead in establishing the necessary structures able to manage the long-term European research programmes in radiation protection, also taking advantage of the valuable experience gathered through the DoReMi network of excellence. Whilst in fields adjacent to low-dose risk research (radioeco ...
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 71

 TERMINÉ 

Initial Training Network for Neurogical disorders orchestrated by cytoKines (NEUROKINE)

Date du début: 1 janv. 2013, Date de fin: 31 mai 2017,

Neuroinflammatory disease, in particular multiple sclerosis affects more than 700.000 people within Europe alone. European countries are at the forefront of neuroimmunological research and students in medicine and biology are greatly attracted by the field. Neuroimmunology research further impacts our understanding of the ethiopathology of other CNS-disorders including Alzheimer’s Dementia and Mor ...
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 13

 TERMINÉ 

Enhanced European Coordination for Accelerator Research & Development (EUCARD-2)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2017,

Research accelerators are facing important challenges that must be addressed in the years to come: existing infrastructures are stretched to all performance frontiers, new world-class facilities on the ESFRI roadmap are starting or nearing completion, and strategic decisions are needed for future accelerators and major upgrades in Europe.While current projects concentrate on their specific objecti ...
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 40

 TERMINÉ 

Actuation and characterisation at the single bond limit (ACRITAS)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2017,

"Scanning probe microscopy(SPM) has now evolved to the point where not only is imaging and manipulation with single atom resolution achievable but the state of the art in the field involves sub-molecular and sub-atomic resolution: individual chemical bonds can be resolved, their properties measured, and their spatial symmetry exploited.SPM is, however, increasingly a victim of its own success. The ...
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 12

 TERMINÉ 

Insulator Spintronics (InSpin)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2017,

InSpin will develop revolutionary nano-scale insulator spintronics that can replace or be integrated with conventional electronics and function at ambient temperatures. The innovation lies in the use of spin currents that in magnetic insulators are decoupled from charge currents and propagate with extremely low power dissipation. InSpin's objectives are to provide a disruptive technology that is s ...
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 5

 TERMINÉ 

Role of the mitochondrial anti-viral signaling protein in sepsis (MAVS)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

"Severe sepsis is an important complication of infections and one of the leading causes of morbidity and mortality. For the countries of the European Union it is estimated that approximately 600,000 cases and more than 150,000 deaths occur from sepsis per year. Currently, no approved treatment options are available for the therapy of septic shock in humans.This research proposal intends to investi ...
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 1

 TERMINÉ 

Epidemiological study to quantify risks for paediatric computerized tomography and to optimise doses (EPI-CT)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,

Diagnostic radiation represents an indispensable, sometimes life-saving, tool in modern medicine. However, the growing use of computerized tomography (CT) is a topic of concern in radiological protection, especially for children and adolescents. Children are generally more sensitive to the carcinogenic effects of ionizing radiation than adults. In addition, they have a longer life-span to express ...
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 22

 TERMINÉ 

PanCare Childhood and Adolescent Cancer Survivor Care and Follow-up Studies (PanCareSurFup)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,

Over the last 40 years, treatment for childhood and adolescent cancer has improved greatly; 5- year survival after childhood cancer is now 80% in developed countries. Approximately 1 individual in 750 of young adults is now a childhood cancer survivor. Epidemiologic data on the number of European childhood cancer long-term survivors are not available, but estimates suggest a number between 300,000 ...
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 18

 TERMINÉ 

Orphans Unite: chILD better together – European Management Platform for Childhood Interstitial Lung Diseases (CHILD-EU)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2016,

Children with diffuse lung disease, also called childhood interstitial lung diseases (chILD), may have one of more than 200 entities, the biggest group of respiratory orphan lung diseases. Frequently undiagnosed because of lack of awareness or complex differential diagnosis, they lead to much morbidity, mortality (about 15%) and psychosocial stress for the families. Current lack of evidence based ...
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 10

 TERMINÉ 

Morphogenetically active blood vessels: Proof-of-Concept (MorphoVES-PoC)

Date du début: 1 avr. 2015, Date de fin: 30 sept. 2016,

"Cardiovascular diseases are the leading causes of mortality in Europe and worldwide. Currently, synthetic prostheses used in bypass vascular surgery are produced from polyethylene terephthalate [PET] and expanded polytetrafluoroethylene [ePTFE]. Those materials show less than optimal, insufficient biocompatibility and durability properties, especially if used for SMALL DIAMETER BLOOD VESSELS. Wit ...
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 1

 TERMINÉ 

Molecular Quantum Spintronics (MoQuaS)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,

MoQuaS aims at developing devices and protocols to read out and process quantum information using individual molecular spins embedded in electronic circuits. To this end, prototypical hybrid nano-devices addressing single molecular spins will be designed and reliable methods for their realization will be developed. Core of such nano-architectures are magnetic molecules, specifically functionalized ...
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 5

 TERMINÉ 

Emulators of Quantum Frustrated Magnetism (EQuaM)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,

Among complex systems with emergent behaviours, frustrated quantum magnets are predicted to exhibit novel, highly nontrivial phases of matter that may play a major role in future and emerging quantum technologies such as the synthesis of innovative materials for energy harnessing and storage, entanglement-enhanced metrology, and topological quantum computing.Unfortunately, due to the intrinsic lev ...
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 8

 TERMINÉ 

Quantum sensor technologies and applications (QTea)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

This training network focuses on the development of modern quantum sensors based on precision measurements of inertial forces, electro-magnetic fields, and time. Important ideas and major contributions to current research in this field have originated from atomic physics and quantum optics. The topics covered are gravitational probing, rotational sensing, field probes, and atomic clocks, with pote ...
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 11

 TERMINÉ 

BlueGenics – From gene to bioactive product: Exploiting marine genomics for an innovative and sustainable European blue biotechnology industry (BlueGenics)

Date du début: 1 août 2012, Date de fin: 31 juil. 2016,

Marine organisms, in particular sponges and their associated microorganisms, are an inexhaustible source of novel bioactive (lead) compounds for biomedical application. Industrial exploitation of this natural resource using traditional approaches is, however, hampered, with a few exceptions, by unsolvable supply problems - despite of numerous efforts in the past. Therefore, there is, very likely, ...
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 18

 TERMINÉ 

Natural inorganic polymers and smart functionalized micro-units applied in customized rapid prototyping of bioactive scaffolds (Bio-Scaffolds)

Date du début: 1 juin 2013, Date de fin: 31 mai 2016,

The application of rapid prototyping techniques has become a new trend in the fabrication of customized scaffolds for tissue regeneration or repair. The aim of the proposed project is to provide novel solutions for bottle-neck problems currently faced in establishing the corresponding processing chain, which encounter, among others, the extraction of essential geometry data of the damaged tissue f ...
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 5

 TERMINÉ 

Neuro-Enhancement: Responsible Research and Innovation (NERRI)

Date du début: 1 mars 2013, Date de fin: 31 mai 2016,

This project aims to contribute to the introduction of Responsible Research and Innovation in neuro-enhancement (NE) in the European Research Area and to the shaping of a normative framework underpinning the governance of NE technologies. These will be achieved through mobilization and mutual learning (MML) activities engaging scientists, policy-makers, industry, civil society groups and the wider ...
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 19

 TERMINÉ 

From gene to biomineral: Biosynthesis and application of sponge biosilica (BIOSILICA)

Date du début: 1 juin 2011, Date de fin: 31 mai 2016,

"During the last decade, the principles of biomineralization have increasingly attracted multidisciplinary scientific attention, not only because they touch the interface between the organic/inorganic world but also because they offer fascinating bioinspired solutions to notorious problems in the fields of biotechnology and medicine. However, only one group of animals has the necessary genetic/enz ...
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 1

 TERMINÉ 

Simulators and Interfaces with Quantum Systems (SIQS)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2016,

The overarching goal of our project is to develop systems based on direct and deterministic interactions between individual quantum entities, which by involving large-scale entanglement can outperform classical systems in a series of relevant applications.We plan to achieve that by improving technologies from atomic, molecular and optical physics as well as from solid-state physics, and by develop ...
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 32

 TERMINÉ 

Biomarker for Cardiovascular Risk Assessment in Europe (BiomarCaRE)

Date du début: 1 oct. 2011, Date de fin: 31 mars 2016,

Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role in the drive towards personalised medicine remains uncertain.Based on harmonised and standardised European population cohorts we have built significant research collabo ...
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 31