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22 projets européens trouvés

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 TERMINÉ 

Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,

Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 TERMINÉ 

Combatting Bacterial Resistance in Europe (COMBACTE-NET)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2019,

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies. The estimated costs of ARB are aro ...
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 38

 TERMINÉ 

NutrImmune: Nutrient-controlled molecular pathways instructing development and function of mucosa-associated innate lymphocytes (NUTRIMMUNE)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

The last decade has witnessed an explosion of research into the molecular networks ensuring maintenance of a mutualistic relationship between microbes and host cell networks at mucosal surfaces. Failure of such homeostatic or adaptive programs lead to susceptibility to intestinal infections or to chronic inflammation causing debilitating human diseases such as inflammatory bowel diseases or inflam ...
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 2

 TERMINÉ 

Synthetic biology – Engaging with New and Emerging Science and Technology in Responsible Governance of the Science and Society Relationship (SYN-ENERGENE)

Date du début: 1 juil. 2013, Date de fin: 30 juin 2017,

Synthetic biology (SynBio) offers huge potential for applications in energy, health and the environment. It also brings with it various challenges such as regulatory issues of biosafety, biosecurity and intellectual property rights, as well as potential environmental and socio-economic risks in developing countries. As yet, however, there is scant public knowledge about the technology. It is thus ...
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 29

 TERMINÉ 

Protease Systems Biology in Tumorigenesis and Neurodegeneration (ProteaSys)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

Proteolysis affects every protein through limited processing or degradation. Unlike other post−translational modifications, proteolysis is irreversible and occurs intra− and extracellularly. The large number of genetically encoded proteases in man (> 560) illustrates the importance of proteolysis. However, the in vivo substrate profiles of most proteases have remained elusive; presenting a major h ...
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 1

 TERMINÉ 

Platform for sharing best practices for management of rare diseases (RARE-BESTPRACTICES)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

RARE-Bestpractices will develop a sustainable networking platform, supporting the collection of standardized and validated data and efficient exchange of knowledge and reliable information on rare diseases (RD).RD are characterized by low prevalence (EU – 5:10000 persons). There are more than 5000, overall affecting about 30 million citizens of all ages in the EU. RD are often life-threatening and ...
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 16

 TERMINÉ 

Machine-readable and interoperable age classification labels in Europe (MIRACLE)

Date du début: 1 févr. 2014, Date de fin: 31 juil. 2016,

Media content is being distributed more and more via electronic networks, and parents as well as their kids receive and access this content with electronic end devices. Where retail boxes traditionally came with visual age labels, the digitalisation of age labels is stuck in a very early stage of development. There is no extensive use of digital age labels yet, especially on the open internet. One ...
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 8

 TERMINÉ 

PROTEOMICS BASED IDENTIFICATION OF BIOMARKERS AND CLEAVAGE PRODUCTS IN PANCREATIC CANCER USING GLYCO-CAPTURE TECHNOLOGY (GLYCOMARKER)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2016,

In cancer biology, primary tumours and metastasis are embedded in a microenvironment comprised of cells such as tumour associated macrophages and cancer-associated fibroblasts. Tumour and stroma derived cytokines form a paracrine loop of mutual activation, often resulting in elevated tumour aggressiveness. Interestingly, numerous studies have shown that altered protein glycosylation is a hallmark ...
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 1

 TERMINÉ 

Novel Statistical Methodology for Diagnostic/Prognostic and Therapeutic Studies and Systematic Reviews (MEDIASRES)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

"Novel statistical methodology promises to greatly facilitate development of approaches for personalised medicine. While state-of-the-art statistical techniques have already advanced clinical trials and diagnostic/prognostic studies as the major source of evidence in clinical medicine, increasing availability of molecular techniques holds an even greater promise. However, for leveraging such infor ...
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 10

 TERMINÉ 

Targeting Src-family tyrosine kinases in chronic autoimmune and inflammatory diseases (TARKINAID)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

The project aims to develop novel inhibitors of chronic autoimmune and inflammatory diseases by targeting members of the Src tyrosine kinase family. Src-family kinases have recently emerged as major therapeutic targets in malignant diseases but their suitability as potential targets of inflammatory diseases has not yet recieved widespread acceptance. On the other hand, members of the applicant con ...
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 11

 TERMINÉ 

Molecular mechanisms of transcriptional regulation of lymphocyte development by the E2A splice variants E12 and E47 (splice)

Date du début: 1 mars 2011, Date de fin: 10 juin 2015,

The E2A gene encodes for two alternatively spliced proteins, namely E12 and E47, which belong to the family of basic helix-loop-helix transcription factors. The E2A proteins have been characterized extensively as regulators during various stages of B and T lymphocyte development. Recently, we have generated mice deficient for either E12 or E47 and examined their roles in B cell maturation. We show ...
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 1

 TERMINÉ 

Molecular mechanisms of fibrinogen function regulating NSC differentiation in CNS injury or disease (FIB)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

After brain injury or neurologic disease, the ability of the central nervous system (CNS) to regenerate is limited. Neural stem cells (NSCs) have the potential to differentiate into neurons and glia, but neurogenesis is incomplete after CNS disease because of a changed extracellular environment. The identification of novel factors responsible for regulating NSC fate is necessary for the molecular ...
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 1

 TERMINÉ 

European Communication on Research Awareness Needs (ECRAN)

Date du début: 1 sept. 2012, Date de fin: 31 août 2014,

"The ECRAN (European Communication on Research Awareness Needs) project is designed to develop a portfolio of open educational resources, including a film, for the general population about the challenges raised by independent clinical research.The European Commission (FP7 Health Priority) decided to allocate substantial funding to independent (investigator-driven) clinical trials. Together with me ...
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 10

 TERMINÉ 

Regulation of Inflammation by Macrophages in Chronic Granulomatous Diseases (RIMinCGD)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2014,

Chronic granulomatous disease (CGD) affects children and young adults and is associated with significant morbidity, mortality and socio-economic costs. CGD is caused by the genetic deficiency of NADPH oxidase (Nox). The characteristic lesion in CGD is the development of granulomas, or confined areas of tissue inflammation, which are characterized by the presence of macrophages (Mph) and Mph-deriv ...
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 1

 TERMINÉ 

Overcome failure to Publish nEgative fiNdings (OPEN)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2013,

Full information about completed and ongoing clinical trials is the indispensable base for decision making about medical therapies and diagnostic procedures by patients and doctors. Equally, researchers and research organisations, ethics boards, governments and health system agencies, courts for social justice, pharmaceutical companies and all professional groups of the health care system are depe ...
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 11

 TERMINÉ 

"Early diagnosis, treatment and prevention of mood disorders targetting the activated inflammatory response system" (MOODINFLAME)

Date du début: 1 nov. 2008, Date de fin: 30 avr. 2013,

"Partners come from 10 European countries to achieve two main objectives: A) The further exploration of 3 animal models (the OBX rat, GS rat and NOD mouse) characterized by an activated immune response system (IRS), an abnormal tryptophan catabolism and a depressive-like behaviour to study the pathogenesis of inflammation-related mood disorders and the efficacy/working mechanism of anti-inflammat ...
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 21

 TERMINÉ 

Detecting and Eliminating Bacteria UsinG Information Technologies (DebugIT)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2012,

Description For infectious diseases DebugIT detects patient safety related patterns and trends, acquires knowledge and uses this for better quality healthcare In about half a century of antibiotic use, unexpected new challenges have come to light: fast emer-gence of resistances among pathogens, mi ...
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 14

 TERMINÉ 

EUROPEAN DRUG INITIATIVE ON CHANNELS AND TRANSPORTERS (EDICT)

Date du début: 1 févr. 2008, Date de fin: 30 juin 2012,

"The European Drug Initiative on Channels and Transporters, EDICT, allies for the first time, partners with world-class expertise in both the structural and functional characterisation of membrane channels and transporters. State-of-the-art facilities and personnel for X-ray crystallography, Electron Microscopy and Nuclear Magnetic Resonance and the latest throughput technology, will provide infra ...
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 28

 TERMINÉ 

Understanding and fighting metastasis by modulating the tumour microenvironment through interference with the protease network (MICROENVIMET)

Date du début: 1 mars 2008, Date de fin: 29 févr. 2012,

"The MICROENVIMET project proposes innovative approaches for building a comprehensive understanding of the interplay between cancer cells and their microenvironment both at primary and secondary sites. The objectives are to identify molecular pathways involved in the regulation of metastatic dissemination to lung, liver, lymph node and bone. To achieve these objectives, the original experimental a ...
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 9

 TERMINÉ 

Pemphigus - From autoimmunity to disease (Pemphigus)

Date du début: 1 mai 2008, Date de fin: 31 oct. 2011,

Pemphigus is a potentially lethal bullous disease of the skin and mucosa and may be considered as a paradigmatic organ-specific autoimmune disease due to 1) its well-defined autoantigens, 2) the knowledge of critical events of its immune pathogenesis and 3) the reproducibility of major clinical and pathogenic features in suitable animal models. Overall, understanding the etiopathogenesis of pemphi ...
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 7

 TERMINÉ 

Combating influenza using a novel drug strategy (FluDrugStrategy)

Date du début: 1 mars 2008, Date de fin: 31 août 2010,

Objective: To find and produce novel target compounds against the influenza virus. Influenza A capsid protein is the target since it does not mutate at the same rate as the Hemagglutinin or Neuraminidase proteins. We aim to develop new therapeutic antiviral solutions to combat the disease. Beyond state of the art: The project combines knowledge based design and synthesis of compounds with unique p ...
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 5

 TERMINÉ 

Small Molecule Inhibitors of the Trimeric Influenza Virus Polymerase Complex (FLUINHIBIT)

Date du début: 1 avr. 2008, Date de fin: 31 mars 2010,

"The clock is counting down to the next influenza pandemic. Since 1997, the avian influenza virus strain H5N1 has infected over 250 people worldwide with a fatality rate of ~60%, although so far without sustained human-to-human transmission. In view of the very few efficacious drugs against influenza virus infections and the time it takes to develop a matching vaccine, there is an unmet worldwide ...
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 6