8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy In TYpe 2 diabetic patients with normoalbuminuria (PRIORITY)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,
Patients with diabetes are at risk of developing diabetic nephropathy, which will ultimately result in the requirement for renal replacement therapy and is also associated with high cardiovascular morbidity and mortality. Detection of low concentrations of albuminuria in urine (microalbuminuria) is the current clinical standard for detecting those at significant risk and targeting preventive treat ...
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21
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TERMINÉ
Personalized minimization of immunosuppression after solid organ transplantation by biomarker-driven stratification of patients to improve long-term outcome and health-economic data of transplantation (BIO-DrIM)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,
Organ transplantation has emerged as the “gold standard” therapy for end-stage organ failure. Incomplete control of chronic allograft injury but also the adverse effects of long-term immunosuppression (IS) continue to challenge the long-term success of transplantation. The paradigm is shifting from increasing “net”-IS by novel drugs to the concept of minimizing long-term IS as early as possible. H ...
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17
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TERMINÉ
Role of Epoxyeicosatrienoic Acids in the Regulation of Blood Pressure, Renal Hemodynamics and Sodium Excretion in Renovascular Model of Hypertension (Renal functions/EETs)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2016,
Cytochrome P450 (CYP) metabolites are more frequently recognized as important regulators of cardiovascular and renal functions. CYP epoxygenases produce epoxyeicosatrienoic acids (EETs) that exhibit vasodilatory and natriuretic properties. EETs are degraded by the enzyme soluble epoxide hydrolase (sEH). Inhibition of sEH increases the level of EETs and attenuates blood pressure (BP) and end organ ...
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1
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TERMINÉ
European Training Network for Excellence in Molecular Imaging in Diabetes (BETATRAIN)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
...unctional and molecular imaging methods, which only recently have become available for in vivo diabetes imaging. However, it remains difficult to build up top level expertise as few, if any, European institutions are able to offer a profound combined molecular imaging/diabetes training, a shortcoming that continues to hamper the progress of the field. As a consequence, most available molecular ima ...
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10
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TERMINÉ
A Europe-wide Strategy to enhance Transplantation of highly sensitized patients on basis of Acceptable HLA Mismatches (EUROSTAM)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2015,
The presence of donor specific HLA antibodies is a contra-indication for renal transplantation. Highly sensitized patients accumulate and often die on the transplant waiting lists as it is almost impossible to find donors towards which they don’t have antibodies. The acceptable mismatch program of Eurotransplant has shown to be an effective tool to enhance successful transplantation of highly sens ...
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11
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TERMINÉ
Development of OPN-305 as an orphan drug for the treatment of Delayed Graft Function post solid organ transplantation (MABSOT)
Date du début: 1 déc. 2010, Date de fin: 30 sept. 2014,
Delayed graft function (DGF) is defined as the need for dialysis within seven days of renal transplantation (DGF promotes allograft rejection, requires prolonged dialysis and hospitalisation, and increases the likelihood of graft failure and ultimately the duration of renal graft survival-expectancy. The incidence of DGF occurs in 21-44% of cases following cadaveric renal graft. Several rare dise ...
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10
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TERMINÉ
European Network for Cell Imaging and Tracking Expertise (ENCITE)
Date du début: 1 juin 2008, Date de fin: 30 nov. 2012,
"Cell therapy can be defined as the transplantation of living cells for the treatment of medical disorders. Three different principles underlie the increasing interest in cell therapy. 1. Transplanted cells used as an “active drug” 2. Transplanted cells used to replace damaged and degenerated tissue. 3. Cells used as a drug delivery vehicle. Promising results have been obtained in pre-clinical and ...
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30
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TERMINÉ
Personal Glucose Predictive Diabetes Advisor (DIAdvisor)
Date du début: 1 mars 2008, Date de fin: 30 juin 2012,
The DIAdvisor is a large scale integrating project (IP) aiming at development of a prediction based tool which uses past and easily available information to optimise the therapy of type I and developed type II diabetes.The DIAdvisor does not depend on specific sensor technologies and technologies like standard strip sensing, minimally-invasive continuous glucose sensors and non-invasive methods.Fo ...
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