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31 projets européens trouvés

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 TERMINÉ 

CRACKING THE CODE BEHIND MITOTIC FIDELITY: the roles of tubulin post-translational modifications and a chromosome separation checkpoint (CODECHECK)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

During the human lifetime 10000 trillion cell divisions take place to ensure tissue homeostasis and several vital functions in the organism. Mitosis is the process that ensures that dividing cells preserve the chromosome number of their progenitors, while deviation from this, a condition known as aneuploidy, represents the most common feature in human cancers. Here we will test two original concep ...
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 1

 TERMINÉ 

The Pancreas Regulome: From causality to prediction of non-coding mutations in human pancreatic diseases (ZPR)

Date du début: 1 juin 2016, Date de fin: 31 mai 2021,

Several human pancreatic diseases have been characterized, being the diabetes the most common. Like others, this genetic disease is related to disrupted non-coding cis-regulatory elements (CREs) that culminate in altered gene expression. Although Genome Wide Association Studies support this hypothesis, it’s still unclear how mutations on CREs contribute to disease. The translation from the “non-co ...
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 1

 TERMINÉ 

Mechanisms of actomyosin-based contractility during cytokinesis (ACTOMYO)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,

Cytokinesis completes cell division by partitioning the contents of the mother cell to the two daughter cells. This process is accomplished through the assembly and constriction of a contractile ring, a complex actomyosin network that remains poorly understood on the molecular level. Research in cytokinesis has overwhelmingly focused on signaling mechanisms that dictate when and where the contract ...
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 1

 TERMINÉ 

Molecular control of self-renewal and lineage specification in thymic epithelial cell progenitors in vivo. (TEC_Pro)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,

The development of vaccines for the treatment of infectious diseases, cancer and autoimmunity depends on our knowledge of T-cell differentiation. This proposal is focused on studying the thymus, the organ responsible for the generation of T cells that are responsive against pathogen-derived antigens, and yet tolerant to self. Within the thymus, thymic epithelial cells (TECs) provide key inductive ...
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 1

 TERMINÉ 

Folate-Target Nanodevices To Activated Macrophages For Rheumatoid Arthritis (FOLSMART)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

FOLSMART will bring to phase I clinical trials novel folate-based nanodevices (FBN) for the treatment of rheumatoid arthritis (RA). These nanodevices for folic acid (FA)-mediated targeting of activated macrophages showed improved clinical scores in a mouse model of RA when compared to methotrexate (MTX), a first-line drug therapy for the treatment of RA. In this way, FBN will be benchmarked agains ...
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 8

 TERMINÉ 

Cytoplasmic Dynein: Mechanisms of Regulation and Novel Interactors (DYNEINOME)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

"The megadalton cytoplasmic dynein complex, whose motor subunit is encoded by a single gene, provides the major microtubule minus end-directed motility in cells and is essential for a wide range of processes, ranging from the transport of proteins, RNA, and membrane vesicles to nuclear migration and cell division. To achieve this stunning functional diversity, cytoplasmic dynein is subject to tig ...
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 1

 TERMINÉ 

Clinical Studies on a Multivalent Vaccine for Human Visceral Leishmaniasis (MuLeVaClin)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

The World Health Organisation in its report on Neglected Tropical Diseases has stated that there is overwhelming evidence to show that the burden caused by many of the 17 diseases that affect more than 1billion people worldwide can be effectively controlled and, in many cases, eliminated or even eradicated. Leishmaniasis caused by Leishmania spp is one of them and poses a grave health risk to an e ...
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 9

 TERMINÉ 

Cyclic nucleotide signalling in the human pathogen Listeria monocytogenes (a-Sign)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2018,

Nucleotides are the building blocks of nucleic acids and have emerged as significant determinants in energy transfer and signalling. Four nucleotides are known to function as signalling molecules in bacteria, namely the cyclic mono-nucleotides cAMP and cGMP, and the cyclic di-nucleotides c-di-AMP and c-di-GMP. These molecules play specific and distinct roles in many bacterial species, and can co-e ...
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 1

 TERMINÉ 

Euro-BioImaging Preparatory Phase II - Project (EuBI PPII)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2017,

Euro-BioImaging (EuBI) is the pan-European research infrastructure project for imaging technologies in biological and medical sciences and has been on the ESFRI Roadmap since 2008. In close match with the scope and objectives of the INFRADEV2 call, Preparatory Phase II (PPII) funding will enable EuBI:• to finalize the submission and approval procedure of its ERIC statutes with the EC and bring the ...
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 21

 TERMINÉ 

Foreseeing Opportunities, Risks and Emergent Science Issues for the next Generation: Highlighting Trends (FORESIGHT)

Date du début: 1 juin 2016, Date de fin: 30 nov. 2017,

Our proposal for ERN 2016-17 is focussed on foresight, exploring alternatives to consider and manage the future with researchers and the public, envisioning new trends of science and technologies and of their impacts on society. Of special concern are the complex problems and challenges that humanity faces: climate change, sustainable energy, food and water supply, ageing and social inclusion, to ...
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 4

 TERMINÉ 

Equipping European Primary Care Health Professionals to Deal with Genetics

Date du début: 1 sept. 2014, Date de fin: 31 août 2017,

With one person in 20 being affected by a genetic condition in their lifetime, medical professionals in primary care are increasingly expected to deliver genetic services in daily patient care. Professionals in primary care are increasingly expected to answer patient queries about genetic conditions, deliver genetic information and triage patients who require genetic or other specialist services ...
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 7

 TERMINÉ 

New Medicines for Trypanosomatidic Infections (NMTRYPI)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2017,

The infectious diseases burden imposed by the parasites of Trypanosomatidae family represents a huge problem on people’s lives in countries where these diseases are endemic. Problems associated with existing drugs include inefficient delivery, insufficient efficacy, excessive toxicity and increasing resistance. New drugs are urgently needed now and in the foreseeable future. The New Medicine for T ...
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 14

 TERMINÉ 

An ethical, legal and practical perspective on the impact of a new regulatory framework for the scientific use of animals on research and innovation (ANIMPACT)

Date du début: 1 oct. 2013, Date de fin: 31 déc. 2016,

Research with animals is considered necessary to obtain certain vital knowledge for advancing health research and innovation, but the harm such research may cause animals is ethically problematic. The European legislation regulating animal experimentation is based on the need to balance the two important interests at stake: advancing research and protecting animal welfare. The public sensitivity o ...
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 6

 TERMINÉ 

Kinetoplastid Drug Development: strengthening the preclinical pipeline (KINDRED)

Date du début: 1 sept. 2013, Date de fin: 31 août 2016,

The trypanosomatid diseases, leishmaniasis, Human African trypanosomiasis (HAT) and Chagas disease (CD), continue to impart a heavy toll on human health. The treatments available are limited and threatened by drug resistance with few newdrugs in the pipeline. The KINDReD consortium integrates five leading academic laboratories in Europe (Portugal, United Kingdom, and Switzerland), the USA (Califor ...
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 14

 TERMINÉ 

Neuro-Enhancement: Responsible Research and Innovation (NERRI)

Date du début: 1 mars 2013, Date de fin: 31 mai 2016,

This project aims to contribute to the introduction of Responsible Research and Innovation in neuro-enhancement (NE) in the European Research Area and to the shaping of a normative framework underpinning the governance of NE technologies. These will be achieved through mobilization and mutual learning (MML) activities engaging scientists, policy-makers, industry, civil society groups and the wider ...
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 19

 TERMINÉ 

Spatiotemporal regulation of chromosome segregation fidelity (PRECISE)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

At any given moment, 250 million cells are dividing in the human body through an essential process known as mitosis. Inaccuracy of mitosis leads directly to aneuploidy (gain or loss of chromosomes), a hallmark of several cancers and birth defects. Mitotic fidelity is controlled by the spindle assembly checkpoint (SAC), a signaling pathway that delays the progression of mitosis to ensure that all c ...
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 1

 TERMINÉ 

Design, construction and demonstration of solar biofuel production using novel (photo)synthetic cell factories (CYANOFACTORY)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2015,

CyanoFactory brings together ten selected leading, highly complementary European partners with the aim to carry out integrated, fundamental research aiming at applying synthetic biology principles towards a cell factory notion in microbial biotechnology. The vision is to build on recent progress in synthetic biology and develop novel photosynthetic cyanobacteria as chassis to be used as self-susta ...
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 10

 TERMINÉ 

DIAGNOSTIC ET COMBAT MOLÉCULAIRE DE TROIS MALADIES NEURODÉGÉNÉRATIVES (PARKINSON, FENILCETONURIA ET AMILOIDOSIS TTR) (NEUROMED)

Date du début: 30 avr. 2014, Date de fin: 29 juin 2015,

Les maladies neurodégénératives comme Parkinson représentent un défi pour la science actuelle. Certaines de ces maladies neurodégénératives sont considérées comme maladies rares comme la phénylcétonurie et la polyneuropathie amyloïde familiale (FAP) associée à la transthyrétine (TTR), dont le traitement ne prévaut pas dans l'industrie pharmaceutique.Pour combler ce manque, NEUROMED prétend dévelop ...
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 6

 TERMINÉ 

Understanding the coordination between mitosis and cell polarity in Drosophila (COMITPOL)

Date du début: 1 janv. 2012, Date de fin: 26 janv. 2014,

"Shaping the tissues that make an organism requires a tight control of cell division and mechanisms that spatially distribute signalling cues and adhesive structures within single cells. Although cell division and polarity have been extensively studied, how these processes are coordinated is largely unknown.The primary goal of this project is to understand the link between regulation of mitotic ce ...
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 1

 TERMINÉ 

How will life be in 2020? (Future2020)

Date du début: 1 mai 2013, Date de fin: 30 nov. 2013,

This proposal aims to raise awareness of the prominent role researchers and how their work plays in our currently every day and for the future. Bearing in mind Horizon 2020 Societal Challenges, the ERN2013 will promote and disseminate what in terms of science and innovation is being done in Portugal.The extensive and nationwide range of activities already planned and being prepared have one major ...
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 10

 TERMINÉ 

Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases (NANOFOL)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2013,

"NANOFOL proposes to develop a new diagnostic/therapy approach using folate based nanobiodevices (FBN) able to provide a new type of cost efficient treatment for chronic inflammatory diseases such as Atherosclerosis and Rheumatoid Arthritis with low side effects that will constitute a more advantageous solution than current therapies. NANOFOL will achieve all that by fulfilling the following obje ...
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 14

 TERMINÉ 

Structural studies of peroxisomal machinery (StrucPer)

Date du début: 1 sept. 2009, Date de fin: 31 août 2013,

Peroxisomes are organelles responsible for essential metabolic processes such as fatty acid oxidation. These organelles contain specialized machinery for protein import and membrane protein insertion. These systems have been well characterized at the genetic, cellular and biochemical level and there is a good understanding of the number and identity of the different components and their functional ...
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 1

 TERMINÉ 

Study of proteins involved in oligodendrocyte process extension that regulate axon-glia interactions (OligProcessExtension)

Date du début: 1 avr. 2011, Date de fin: 28 août 2013,

Oligodendrocytes are the myelinating cells of the central nervous system (CNS). The importance of myelination is illustrated by the neurological consequences caused by demyelination, the process or state resulting from the loss or destruction of myelin such as in multiple sclerosis (MS), the most frequent CNS chronic demyelinating disease. Failure of remyelination is thought to be the major cause ...
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 1

 TERMINÉ 

Breaking the riddle of amylin’s role in nociception: a comprehensive study on the action of amylin in multiple pain models (AMYLIN_ROLE_PAIN)

Date du début: 1 août 2011, Date de fin: 31 juil. 2013,

"Pain is more than a symptom, it can develop into a disabling disease. Amylin is a hormone with several metabolic effects that has shown to also influence the nociceptive system. The literature is however contradicting as some authors claim to find analgesic effects under amylin treatment, while others suggest no action or a pronociceptive role for this hormone. As chronic pain involves pathophysi ...
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 1

 TERMINÉ 

Science in the Streets (SiS)

Date du début: 1 mai 2012, Date de fin: 30 nov. 2012,

This proposal aims to raise awareness of the prominent role researchers and their work play in our everyday life. The extensive and nationwide range of activities already planned and being prepared have one major aim: to show that researchers are ordinary people with extraordinary jobs! This will be done through direct engagement of both the general public and researchers in science awareness acti ...
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 9

 TERMINÉ 

Coopération transnationale pour l'innovation technologique dans le développement de molécules pour le traitement de l'obésité et du diabète (DIOMED)

Date du début: 31 mars 2009, Date de fin: 30 mars 2012,

DIOMED pretende contribuir a hacer frente a las barreras que limitan el desarrollo del sector biomédico en la zona SUDOE. El proyecto impulsará la transferencia de conocimiento e innovaciones de la universidad a la empresa lo que ayudará a acortar el tiempo para lograr la convergencia con el resto de Europa en cuanto a impacto económico y creación de empleo en sectores sector de ciencias de la vid ...
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 6

 TERMINÉ 

SENSITIVE TECHNOLOGIES AND EUROPEAN PUBLIC ETHICS (STEPE)

Date du début: 1 mai 2008, Date de fin: 31 déc. 2011,

"This proposal is to establish a Consortium to provide academic input into the planned Eurobarometer Survey on the Life Sciences and Sensitive Technologies in 2008. It is also intended to add value to the survey and thereby enhance its impact and policy relevance with extensions of a conceptual, contextual and a methodological nature. First, we introduce the concept ‘public ethics’, moving beyond ...
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 13

 TERMINÉ 

SOS - Science on Screen (ScienceOnScreen)

Date du début: 1 mai 2011, Date de fin: 30 nov. 2011,

Everyday we are flooded with scientific terms: in the media, at the supermarket, at the pub with our friends. But who makes this science? And how is it done? How is a scientists’ everyday life? Who better to set things straight than scientists themselves?Using amusing but accurate real life stories, this proposal aims for the production of a television show, to be broadcast on the 23rd of Septembe ...
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 5

 TERMINÉ 

Understanding the axon-glial functional unit in myelination and remyelination (AXOGLIA)

Date du début: 1 mars 2009, Date de fin: 31 juil. 2011,

"Loss or damage of myelin is one of the major mechanisms underlying the pathology of several neurological disorders, e.g. leukodystrophies, central and peripheral neuropathies, and inflammatory demyelinating diseases such as multiple sclerosis (MS), a serious health as well as economic and social burden at European level. Remyelination, the process by which demyelinated axons are reinvested with n ...
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 1

 TERMINÉ 

Setting a New Stage in Portugal: Researchers and the public come together through Arts and Sports (SettingTheStage II)

Date du début: 1 mai 2010, Date de fin: 30 nov. 2010,

Continuing the SettingTheStage project organized in 2009, scientists will be called again on stage to celebrate the Researchers’ Night 2010 not only through performing arts (incl. theatre) but also through sports. These media will allow scientists to express themselves, their visions and their work. SettingTheStage II brings back together entities from four major cities across Portugal (North, Cen ...
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 9

 TERMINÉ 

Setting the Stage in Portugal: researchers and the public come together through theatre (SettingTheStage)

Date du début: 1 mai 2009, Date de fin: 30 nov. 2009,

Through the medium of theatre and visual arts, SettingTheStage brings together research centres, universities, an SME, a science museum and theatre groups from four major cities in Portugal, to create multiple spaces where scientists and the public can actively engage in the reality of being a scientist and in the two big scientific celebrations of 2009: the 400th anniversary of Galileo's first us ...
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 9