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Plus de 40 projets européens trouvés

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 EN COURS 

Federation for FIRE Plus (Fed4FIREplus)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The Fed4FIRE+ project has the objective to run and further improve Fed4FIRE’s “best-in-town” federation of experimentation facilities for the Future Internet Research and Experimentation initiative. Federating a heterogeneous set of facilities covering technologies ranging from wireless, wired, cloud services and open flow, and making them accessible through common frameworks and tools suddenly op ...
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 24

 EN COURS 

Optimizing a deployable high efficacy malaria vaccine (OptiMalVax)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

A highly effective malaria vaccine against Plasmodium falciparum should help prevent half a million deaths from malaria each year. New vaccine technologies and antigen discovery approaches now make accelerated design and development of a highly effective multi-antigen multi-stage subunit vaccine feasible. Leading malariologists, vaccine researchers and product developers will here collaborate in ...
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 17

 EN COURS 

Institut Curie 3-i PhD Program (IC-3i-PhD)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

The new IC-3i-PhD program of Institut Curie and its partners will produce top-level scientific knowledge by promoting basic interdisciplinary research that will be translated into novel therapeutic avenues for diagnosis and treatment. The completely re-structured, revitalized, and ambitious international “Triple i” PhD program is strengthened by trans- and inter-disciplinary and inter-sectorial re ...
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 1

 EN COURS 

Chromatin Adaptations through Interactions of Chaperones in Time (ChromADICT)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

A central question in chromatin biology is how to organize the genome and mark specific regions with histone variants. Understanding how to establish and maintain, but also change chromatin states is a fundamental challenge. Histone chaperones, escort factors that regulate the supply, loading, and degradation of histone variants, are key in their placement at specific chromatin landmarks and bridg ...
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 1

 EN COURS 

New therapies for uveal melanoma (UM Cure 2020)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Uveal melanoma (UM) is a rare intraocular tumour with an incidence of 5 cases per million individuals per year. Up to 50% of UM patients develop metastases, most often in the liver, and these are invariably fatal. Despite new discoveries in the genetic and molecular background of the primary tumour, little is known about the metastatic disease; furthermore, there is no therapy to either prevent or ...
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 13

 TERMINÉ 
During mammalian development, precise gene expression patterns have to be established and then maintained, or reversed, in different cellular and tissue contexts. A striking example of such developmentally regulated gene control is X-chromosome inactivation (XCI), whereby one of the two X chromosomes in females is silenced during embryogenesis. XCI is initiated by the non-coding Xist RNA, which co ...
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 1

 TERMINÉ 

Breast Cancer Risk after Diagnostic Gene Sequencing (BRIDGES) (BRIDGES)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Breast cancer affects more than 360,000 women per year in the EU and causes more than 90,000 deaths. Identification of women at high risk of the disease can lead to disease prevention through intensive screening, chemoprevention or prophylactic surgery. Breast cancer risk is determined by a combination of genetic and lifestyle risk factors. The advent of next generation sequencing has opened up th ...
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 20

 TERMINÉ 

Unravelling the Genomic Targets of Drugs Using High-Throughput Sequencing (Drug-Seq)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

This proposal is centred on the development of small molecule probes derived from DNA damaging agents to identify their genomic targets using a novel unbiased approach. Although, several genotoxic drugs have been used for decades to treat cancers, the exact mechanisms by which they operate are not fully understood. It is established that these compounds interfere with the processes of transcriptio ...
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 1

 TERMINÉ 
The proposed European Concerted Programme on Radiation Protection Research (acronym: CONCERT) aims to contribute to the sustainable integration of European and national research programmes in radiation protection. It will do so by focusing resources and efforts in five key directions:• Bring together the elements of the European scientific communities in the fields of radiation effects and risks, ...
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 36

 TERMINÉ 
Parkinson’s disease (PD) is a major, chronic, non-communicable disease and the 2nd most frequent neurodegenerative disorder worldwide. Excess iron is primarily detected in the substantia nigra pars compacta, where dopaminergic neurons are exposed to high levels of oxidative stress produced by mitochondrial disorders and dopamine metabolism. Our previous preclinical, translational and pilot clinica ...
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 17

 TERMINÉ 
Deep water formed around the Antarctic continent drives the world ocean circulation. 50-70% of this deep water is formed within only about 10% of the Antarctic circumpolar band: the Weddell Sea. Subtle changes in the circulation of the Weddell Sea can lead to major changes in floating ice-shelves, with critical implications for global sea-level, the production of deep water and the global ocean ov ...
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 2

 TERMINÉ 
The cell is the universal unit of living matter, and there cannot be propagation of life without cell division. DivIDe aims to investigate the mechanisms and principles of cell division and to reproduce them in vitro with synthetic approaches. Crucial to cell division is the mitotic spindle, a structure whose main duty is the separation of chromosomes. The spindle is made of microtubules (MT), mol ...
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 9

 TERMINÉ 
Neurodegenerative diseases, such as Parkinson’s disease, are a major public health issue given the aging population in Europe and beyond. While curative pharmacological treatment of these diseases is not in sight, cell replacement therapies (CTs) are considered very promising, in particular with the advent of stem-cell reprogramming technologies. However, a fundamental challenge in the medical app ...
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 6

 TERMINÉ 
Blood-based biomarkers such as Circulating Tumor Cells (CTCs), circulating free tumor DNA (cfDNA) and microRNAs (miRNAs) have the potential to improve the development of personalized medicines for cancer patients. This is of particular importance when biopsies of the primary tumor or metastases are not accessible (e.g. at early disease stages or in minimal residual disease) or possible and the ass ...
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 34

 TERMINÉ 
98% of the human genome is non-protein coding raising the question of the role of the dark matter of the genome. It is now admitted that pervasive transcription generates thousands of noncoding transcripts that regulate gene expression and have broad impacts on development and disease. Among the long non coding (lnc)RNAs, antisense transcripts have been poorly studied despite their putative regula ...
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 1

 TERMINÉ 
ProteinConjugates is an inter- and multi-disciplinary network for the education of talented young scientists who will learn how to rationally design and construct the next generation of chemically-defined and innovative protein drug-conjugates for the targeted treatment of serious conditions such as cancer or rheumatoid arthritis. A complementary interaction between academy and pharmaceutical indu ...
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 8

 TERMINÉ 
The ability of cells to polarize underlies the most basic biological functions such as motility and response to external challenges, but also the formation and maintenance of tissues in a multicellular organism. The importance of cell polarity is underscored by the fact that cell polarity is essential for animal development and is perturbed in disease states such as cancer. Understanding cell pola ...
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 9

 TERMINÉ 
T cell cross priming (the initiation of CD8+ T cell responses to antigen that are not expressed by dendritic cells, DCs) requires the phagocytosis of antigens by DCs and their presentation on MHC class I molecules, a process referred to as “cross presentation”. Here, we propose a series of integrated approaches to address the most fundamental mechanisms of cross presentation and explore the use of ...
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 1

 TERMINÉ 

Optimizing and Enhancing the Integrated Atlantic Ocean Observing System (AtlantOS)

Date du début: 1 avr. 2015, Date de fin: 30 juin 2019,

... promote innovation, documentation and exploitation of innovative observing systems. All AtlantOS work packages will strengthen the trans-Atlantic collaboration, through close interaction with partner institutions from Canada, United States, and the South Atlantic region. AtlantOS will develop a results-oriented dialogue with key stakeholders communities to enable a meaningful exchange between the ...
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 63

 TERMINÉ 
Marine (blue) biotechnology is the key to unlocking the huge economic potential of the unique biodiversity of marine organisms. This potential remains largely underexploited due to lack of connectivity between research services, practical and cultural difficulties in connecting science with industry, and high fragmentation of regional research, development and innovation (RDI) policies. To overcom ...
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 27

 TERMINÉ 

Epigenetic Control of Mammalian Reproduction (EPIREPRO)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

By standing at the crossroads of generations, germ cells ensure species continuity. At the time of fertilization, the oocyte and spermatozoon carry the genetic material but also non-genetically encoded, epigenetic information. Gametic epigenetic modifications have immediate effects on gametic production and fertility. They also have long-term consequences on somatic phenotypes when transmitted to ...
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 1

 TERMINÉ 
Atrial fibrillation (AF) is the most common cardiac arrhythmia, with a prevalence of 1.5-2% in European populations. By being a major cause of stroke, dementia, heart failure, and premature death, AF is a major threat to healthy ageing. Despite increasing knowledge on the diverse mechanisms that cause the AF substrate in individual patients, current strategies for prevention and therapy of AF rema ...
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 9

 TERMINÉ 

Endocytic Membrane Compartmentalization by Galectins (GALECTCOMPART)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

The contribution of clathrin-independent endocytosis to the cellular entry of signaling receptors, cell adhesion factors, and other cell surface molecules is well documented. However, how this process is initiated is still unknown. We have recently found that a cellular lectin, galectin-3 (Gal3), entered cells via morphologically distinct tubular structures, so-called clathrin-independent carriers ...
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 2

 TERMINÉ 

Leading Innovative measures to reach gender Balance in Research Activities (LIBRA)

Date du début: 1 oct. 2015, Date de fin: 31 mars 2019,

The main goals of LIBRA are to implement innovative Gender Equality Plans (GEPs) that will empower women researchers to achieve successful careers in science, remove gender barriers and biases at an institutional level, and raise awareness of gender aspects in the experimental design of pre-clinical research projects. To achieve these goals we will: 1) conduct an initial external assessment of eac ...
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 11

 TERMINÉ 

Radiation Innovations for Therapy and Education (RADIATE)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2019,

Approximately 45-60% of all cancer patients are treated with radiotherapy. Some of these patients have a good outcome, but in other cases their illness fails to be cured. This may result from distant metastases or from regrowth of the primary tumor. This training network is built on the premise that considerable advances in understanding radiobiology will open novel routes for effective therapeuti ...
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 6

 TERMINÉ 

Morphogenesis of proliferative epithelial tissue (TIMORPH)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

Shape is a conspicuous and fundamental property of living multicellular organisms. Questions related to embryo shape or morphogenesis have naturally haunted developmental biologists for decades. Recent advances have highlighted that the understanding of the morphogenesis of proliferative tissue will require (i) the dissection of how subcellular cytoskeleton dynamics controls cellular processes suc ...
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 1

 TERMINÉ 

Myosins and the dynamics of intracellular membranes (MYODYN)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Myosins are fascinating proteins with unique biochemical and physical properties. The multiple roles that they play in the dynamics of intracellular membranes are only beginning to emerge. Recent findings from the research team have highlighted unexpected roles in membrane deformation and in membrane fission played by two myosins (myosin 1b and myosin II) functioning at the interface between the G ...
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 1

 TERMINÉ 
Genome-wide studies have revealed that the majority of vertebrate genomes are transcribed and generate large numbers of long intervening noncoding RNAs (lincRNAs). While there is growing evidence that these molecules have functional importance for diverse cellular processes, such as dosage compensation, transcriptional regulation, and reprogramming, the role of lincRNAs in normal development remai ...
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 1

 TERMINÉ 

PERSONALIZED ENGINE FOR CANCER INTEGRATIVE STUDY AND EVALUATION (PrECISE)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

Despite of their great promise, high-throughput technologies in cancer research have often failed to translate to major therapeutic advances in the clinic. One challenge has been tumour heterogeneity, where multiple competing subclones coexist within a single tumour. Genomic heterogeneity renders it difficult to identify all driving molecular alterations, and thus results in therapies that only ta ...
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 10

 TERMINÉ 

Improving Design, Evaluation and Analysis of early drug development Studies (IDEAS)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Drug development is a long and costly process which suffers from the major shortcoming that frequently failure is often only determined during the final stage. Recently, it has been recognised that more care needs to be taken during the early stages of development to avoid going into lengthy and costly confirmatory studies with ineffective or harmful treatments. To achieve this goal it is essentia ...
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 8

 TERMINÉ 

Biochemical and mechanochemical mechanisms in polarized cells (BIOPOL)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

BIOPOL is an interdisciplinary European training network at the interface of cell biology, physics and engineering. BIOPOL aims specifically at the understanding of fundamental mechanochemical principles guiding cellular behaviour and function and their relevance to human disease. A new supra-disciplinary research field is emerging bringing together the fields of molecular cell biology, physics an ...
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 10

 TERMINÉ 

Towards outstanding research and training in tumour biology at IMM (ReTuBi)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

Cancer is a major societal health issue in Europe. In 2012, cancer accounted for around 1.3 million deaths and an estimated economic impact of around € 126 billion in the European Union (EU).The Instituto de Medicina Molecular (IMM) aims to fight this destructive disease by reinforcing its capacity for outstanding pre-clinical and translation research, and by creating a dynamic cluster of excellen ...
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 3

 TERMINÉ 

Waves and Wave-Based Imaging in Virtual and Experimental Environments (WAVES)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Demand for highly trained scientists with a deep understanding of wave propagation in complex media, and capable of exploiting this knowledge to develop imaging tools for seismology and acoustics, is very high in the Earth and environmental sciences. Wave-based imaging serves to map spatial and temporal variations in the structure of the Earth's interior, of the oceans and atmosphere; it is used t ...
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 8

 TERMINÉ 

Dynamics-aerosol-chemistry-cloud interactions in West Africa (DACCIWA)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

"Massive economic and population growth and urbanisation are expected to lead to a tripling of anthropogenic emissions in southern West Africa (SWA) between 2000 and 2030, the impacts of which on human health, ecosystems, food security and the regional climate are largely unknown. An assessment of these impacts is complicated by (a) a superposition with effects of global climate change, (b) the st ...
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 17

 TERMINÉ 
"The EC H2020 funded "Global BioImaging Project" enables Euro-BioImaging, the research infrastructure for access to biological and medical imaging technologies on the ESFRI roadmap, to work together with its international counterparts - the Australian Microscopy and Microanalysis Research Facility (AMMRF), the National Imaging Facility (Australia) and India-BioImaging - on concrete and sustainable ...
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 8

 TERMINÉ 

Enabling a Mobility Back-End as a Robust Service (EMBERS)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2018,

EMBERS will bring to market a back-end for smart city mobility that is developed by a European small enterprise based upon its smart parking and smart traffic management products that two municipalities in Portugal currently deploy. The Mobility Back-end as a Service (MBaaS) replaces such all-in-one systems, in which a municipality purchases the full set of components from a single vendor. Instead ...
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 6

 TERMINÉ 
The I-MOVE+ Consortium includes European Union (EU) Public Health Institutes, SME and Universities. It aims at measuring and comparing the effectiveness (VE) and impact (VI) of influenza and Pneumococcal vaccines and vaccination strategies a in the elderly population in Europe. The goal is to develop a sustainable platform of primary care practices, hospitals and laboratory networks that share val ...
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 33

 TERMINÉ 
F-Interop will develop and provide remotely accessible tools to support and accelerate standardisation processes and products developments, by offsetting several cost and time barriers. It will research and develop a new FIRE experimental platform to support the development of new technologies and standards, from their genesis to the market for: online interoperability tests and validation tools, ...
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 12

 TERMINÉ 
Ewing Sarcomas (ES) are fatal, rare bone cancers particularly affecting young people. About 60% of patients achieve long term survival with current treatment but there has been no improvement in this proportion for 25 years. Treatment is unsuccessful because chemotherapy fails to prevent the development of, or to effectively treat established, metastases. In addition, of the 600 new cases of ES o ...
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 21

 TERMINÉ 

European Clearing House for Open Robotics Development Plus Plus (ECHORD Plus Plus)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Description ECHORD++ will create new opportunities for European robotics researchers to work directly with SME/start-ups and new users/customers to create innovative products. ECHORD++ will continue ECHORD’s two pillars, “experiments” and “structured dialogue”, taking advantage of experience and investment in the infrastructure. In addition, ...
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 68