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10 projets européens trouvés

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 TERMINÉ 

Proteomic investigations of ubiquitin signals in DNA repair and chromatin organization (PROTEUS)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,

"Genome integrity is constantly challenged by endogenous and environmental factors that can induce different types of DNA lesions. Failure to repair DNA lesions can lead to genomic instability and contribute to human diseases such as cancer and premature ageing. To counteract these potentially devastating effects caused by DNA damage, eukaryotic cells have evolved complex DNA repair pathways. Prot ...
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 1

 TERMINÉ 

Mechanistic analysis of DNA damage bypass in the context of chromatin and genome replication (DAMAGE BYPASS)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

During its duplication, DNA, the carrier of our genetic information, is particularly vulnerable to decay, and the capacity of cells to deal with replication stress has been recognised as a major factor protecting us from genome instability and cancer. A major pathway that allows cells to overcome or bypass DNA lesions during replication is activated by posttranslational modifications of the slidin ...
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 1

 TERMINÉ 

Role of the exon junction complex in the splicing of heterochromatic transcripts (EJC_SPLIC_HET)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

"Pre-mRNA splicing is an essential function in virtually all eukaryotic organisms. In the human genome, 95% of the genes with multiple exons are subjected to alternative splicing, increasing the diversity of the transcriptome and ensuring the complexity of the organism. Because of its prevalence in many physiological functions splicing mis-regulation has been linked to a large number of diseases, ...
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 1

 TERMINÉ 

Genomic Targets and Function of Topoisomerase II isoforms during Stem Cell Differentiation (topochromstem)

Date du début: 1 sept. 2012, Date de fin: 31 août 2016,

Topoisomerases are enzymes that solve topological problems arising from DNA templated processes such as replication, transcription, recombination and chromatin remodeling. The type II subfamily of Topoisomerases achieve this task by passing a region of duplex from the same or a different molecule through a double-stranded gap generated in DNA. Mammalian cells encode two isoforms of type II enzymes ...
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 1

 TERMINÉ 

Epigenetic Regulation of Ageing (EpiAge)

Date du début: 1 août 2012, Date de fin: 31 juil. 2016,

Ageing is certainly one of the most interesting but less understood processes of multi-cellular organisms. Although in the last decade great advances have been made to understand the molecular mechanism of ageing a unifying model is still elusive. Research in C. elegans has focussed on the characterization of signalling pathways involved in ageing. It is was demonstrated that the gene expression o ...
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 1

 TERMINÉ 

Epigenetics towards systems biology (EPIGENESYS)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,

The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
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 28

 TERMINÉ 

Elucidating the role of DNA methylation in enhancer priming in vivo (ENHANCEME)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2016,

...oject, in combination with the scientific environment available in the hosting laboratory, will be an excellent stepping-stone to reach full independence and start my own research group at a renowned institute.
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 1

 TERMINÉ 

FUNCTIONS OF CHROMATIN MARKS IN REGULATION OF GENE EXPRESSION (FAME)

Date du début: 1 mars 2013, Date de fin: 29 févr. 2016,

In multicellular organisms, during embryogenesis and tissue homeostasis the differentiation of pluripotent stem cells into a variety of specialized cell types is governed by diverse transcriptional programs, the establishment and maintenance of which rely on epigenetic mechanisms, such as chromatin modifications. Over the past years, a large number of post-translational modifications of histones a ...
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 1

 TERMINÉ 

Functions and mechanism of active DNA demethylation (DNADEMETHYLASE)

Date du début: 1 juin 2010, Date de fin: 31 mai 2015,

Epigenetic gene regulation is of central importance for development and disease. Despite dramatic progress in epigenetics during the past decade, DNA demethylation remains one of the last big frontiers and very little is known about it. DNA demethylation is a widespread phenomenon and occurs in plants as well as in animals, during development, in the adult, and during somatic cell reprogramming of ...
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 2

 TERMINÉ 

Small RNA Mediated Epigenetics in Vertebrates (EPIRNAS)

Date du début: 1 août 2008, Date de fin: 31 juil. 2014,

Since the discovery of RNAi small RNA molecules have been under intense study. They have been shown to impact many different processes, ranging from development to organ function and carcinogenesis. Recently, it has become clear that many distinct small RNA families exist. However, all act through a member of the well-conserved Argonaute family of proteins. I try to understand how specificity of t ...
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 2