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30 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Cardiac Connective Tissue: Beat-by-Beat Relevance for Heart Function in Health and Disease (CARDIONECT)

Date du début: 1 juil. 2013, Date de fin: 30 juin 2019,

Cardiac connective tissue is regarded as passive in terms of cardiac electro-mechanics. However, recent evidence confirms that fibroblasts interact directly with cardiac muscle cells in a way that is likely to affect their beat-by-beat activity.To overcome limitations of traditional approaches to exploring these interactions in native tissue, we will build and explore murine models that express fu ...
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 3

 TERMINÉ 

Epigenetic modifications in glomerular nephropathy and renal aging (RENAL EPIGENETICS)

Date du début: 1 sept. 2011, Date de fin: 11 nov. 2018,

Here, we propose a program to identify the role of mTOR and autophagy dependent epigeneticmodifications during kidney aging. We have assembled a unique set of complementary mouse models including kidney specific and timely inducible autophagy and mTOR deficient mice. For the detailed molecular analysis of transgenic podocyte tissue, we have generated a double-labeled transgenic mouse model, where ...
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 1

 TERMINÉ 

Systems biology for the functional validation of genetic determinants of skeletal diseases (SYBIL)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

"The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth char ...
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 19

 TERMINÉ 

Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases (Neuromics)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics ...
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 20

 TERMINÉ 

nEUROinflammation

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Neuroinflammation is a hallmark of multiple sclerosis and ischemic stroke. Investigating neuroinflammation as a common theme in neurological disorders, this ITN will focus in particular on myeloid cells, microglia, and endothelial cells. Sixteen partners from the academic and private sector with complementary scientific background join forces to train 13 ESRs in neuroinflammatory concepts and tech ...
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 13

 TERMINÉ 

Rapid Adaptive Nonlinear Gradient Encoding for Magnetic Resonance Imaging (RANGEmri)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

The project is aimed at the development of novel approaches for flexible signal localisation and encoding in Magnetic Resonance Imaging (MRI) for applications in neuroscience, neurology, oncology and further areas. The Rapid Adaptive Nonlinear Gradient Encoding for Magnetic Resonance Imaging (RANGE) methodology is based on the concept of applying localised, generally nonlinear encoding fields to f ...
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 1

 TERMINÉ 

A Decision Support System incorporating a validated patient-specific, multi-scale Balance Hypermodel towards early diagnostic Evaluation and efficient Management plan formulation of Balance Disorders (EMBalance)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2016,

Human balance is achieved and maintained by a complex set of sensorimotor systems that include sensory input from vision, proprioception and the vestibular system (motion, equilibrium, spatial orientation); integration of the sensory input; and motor output to the muscles of the eye and body. Failure at the level of the sensory inputs or at the integration of the sensory information by the central ...
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 10

 TERMINÉ 

NEURAL TRANSPLANTATION IN THE TREATMENT OF PATIENTS WITH PARKINSON’S DISEASE (TRANSEURO)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2016,

There are currently no cures for Parkinson's disease (PD) but one of the most effective reparative therapies in patients to date has been with allotransplants of dopamine (DA) neuroblasts obtained from fetal ventral mesencephalic (VM) tissue. However, this cell transplantation approach has given inconsistent results, with some patients doing extremely well and coming off anti-PD medication for yea ...
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 15

 TERMINÉ 

Software for the Use of Multi-Modality images in External Radiotherapy (SUMMER)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

"The greatest challenge for radiation therapy is to reach the highest probability of cure with the least morbidity. In practice, some difficulties remain to identify cancer cells, target them with radiation and minimize collateral damage. Over the last decades, remarkable progress has been made thanks to modern advances in computer and imaging technologies. Currently, the radiotherapy has reached ...
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 7

 TERMINÉ 

Advanced multifunctional zirconia ceramics for long-lasting implants (LONGLIFE)

Date du début: 1 janv. 2012, Date de fin: 30 juin 2015,

The aim of LONGLIFE is to develop new multi-functional zirconia oral and spine (lumbar inter-vertebral disc) implants, with a perfect reliability and a lifetime longer than 60 years. Such an ambitious goal, motivated by the risks and costs associated to revision surgery, will only be reachable by an improvement of the Low Temperature Degradation (LTD) resistance of zirconia and by an enhancement o ...
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 13

 TERMINÉ 

A systems biology approach to dissect cilia function and its disruption in human genetic disease (SYSCILIA)

Date du début: 1 juin 2010, Date de fin: 31 mai 2015,

AIM: To identify the molecular mechanisms characterizing cilium function, and the discrete perturbations associated with dysfunction caused by mutations in inherited ciliopathies, applying a systems biology approach. BACKGROUND: Cilia are microtubule-based, centriole-derived projections from the cell surface. They transduce extracellular signals and regulate key processes in which signals of the e ...
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 17

 TERMINÉ 

Ultra Fast Magnetic Resonance Imaging using One-Voxel-One-Coil Acquisition (OVOC)

Date du début: 1 sept. 2009, Date de fin: 28 févr. 2015,

The proposal is aimed at the development of ultrafast Magnetic Resonance Imaging (MRI) for applications in neuroscience, neurology and oncology. The methodology used is based on the principle of one-voxel-one-coil acquisition in which the sensitive volumes of arrays containing a large number of small receiver coils is used as primary source of spatial localization. This allows to achieve acquisiti ...
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 2

 TERMINÉ 

PREvention of Late Stent Thrombosis by an Interdisciplinary Global European effort (PRESTIGE)

Date du début: 1 déc. 2010, Date de fin: 30 nov. 2014,

"According to the European Society of Cardiology there has been an increase in the life expectancy at the age of 65 of the European population from 15.0 to 17.0 years in the years since 1980. In the elderly, up to 50% of deaths are caused by cardiovascular diseases, the majority accounted for by coronary artery disease. The most effective treatment for obstructive coronary disease is percutaneous ...
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 16

 TERMINÉ 

Experimental Radiotherapy for Malignant Brain Tumours (ERTMABTU)

Date du début: 1 sept. 2010, Date de fin: 31 août 2014,

"The aim of my project is to test two novel experimental radiotherapies which potentially can improve the quality life in patients with malignant brain tumours or with multiple brain metastases. Both methods are being developed at international synchrotron facilities. One of the techniques, microbeam radiation therapy (MRT), is already being studied by several groups and my work is focused on the ...
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 1

 TERMINÉ 

Identification of the genetic and/or epigenetic events that lead to mesenchymal transformation in glioblastoma (GAMNG)

Date du début: 1 oct. 2010, Date de fin: 6 juil. 2014,

"Glioblastoma multiforme (GBM) is the most malignant type of brain tumor in adults with a median survival of one year. The hallmarks of GBM are invasion and neo-angiogenesis. Recently, gene expression studies have established that overexpression of a “mesenchymal” gene signature co-segregate with the poor-prognosis group of glioma patients. We have revealed that two transcription factors, Stat3 an ...
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 1

 TERMINÉ 

Prevention of Hospital Infections by Intervention and Training (PROHIBIT)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2014,

"The aim of PROHIBIT is to understand existing guidelines and practices to prevent healthcare associated infections (HAI) in European hospitals, identify factors that enable and prevent compliance with best practices, and test the effectiveness of interventions of known efficacy. The project will employ a mixed-methods approach combining the strengths of qualitative research, survey methods, obser ...
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 11

 TERMINÉ 

Euro-BioImaging - Research infrastructure for imaging technologies in biological and biomedical sciences (Euro-BioImaging)

Date du début: 1 déc. 2010, Date de fin: 31 mai 2014,

Euro-BioImaging brings together imaging technologies stretching from basic biological imaging with advanced light microscopy, in vivo molecular imaging of single cells to animal models up to the clinical and epidemiological level of medical imaging of humans and populations. Euro-BioImaging, in close consultation with its stakeholders, will address the imaging requirements of both biological and m ...
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 44

 TERMINÉ 

Pharmaceutical Medicine Training Programme (PHARMATRAIN)

Date du début: 1 mai 2009, Date de fin: 30 avr. 2014,

"The proposed Pharmaceutical Medicine Training Programme provides a comprehensive solution for the complex needs of integrated drug development for all professionals involved, incl. physicians, pharmaceutical scientists,biologists, biometricians, health economists, and safety and regulatory scientists from universities, regulatory agencies, large, middle-sized and small pharmaceutical enterprises, ...
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 52

 TERMINÉ 

Medical Imaging Using Bio-inspired and Soft Computing (MIBISOC)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

"Medical imaging (MI) is at the heart of many of today’s improved diagnostic and treatment technologies. Computer-based solutions are vastly more capable of both quantitative measurement of the medical condition and the pre-processing tasks of filtering, sharpening, and focusing image detail. Bio-inspired and Soft Computing (BC, SC) techniques have been successfully applied in each of the fundamen ...
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 8

 TERMINÉ 

Use of innovative strategies for beta-cell imaging in diabetes mellitus (BetaImage)

Date du début: 1 oct. 2008, Date de fin: 31 mars 2013,

The development of sensitive, non-invasive methods for the characterisation and quantification of beta-cell mass would greatly enhance our means for gaining understanding of the pathophysiology of diabetes and allow the development of novel therapies to prevent, halt and reverse the disease. The aim of this project is to develop and apply innovative approaches for beta-cell imaging, the emphasis b ...
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 10

 TERMINÉ 

Development of sensitive methodologies for exploitation of early epigenetic marker diagnosis in major types of cancer (EpiDiaCan)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2012,

Cancer is one of the major causes of mortality. Epithelial cells become malignant after accumulating genetic mutations followed by morphological changes in the epithelium. DNA Alterations include stable genetic changes in oncogenes, tumor suppressor genes and reversible epigenetic changes. Different forms of epigenetic mechanisms have been shown to modify the expression of key genes during tumour ...
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 7

 TERMINÉ 

Promotion of plasticity as a treatment for neurodegenerative conditions (PLASTICISE)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2012,

"Neurodegenerative diseases all cause damage to the circuitry of the nervous system, with loss of connections, axons and neurons. The loss can be gradual, as in Alzheimer’s disease, rapid as in stroke, or intermediate as in the delayed neuronal loss after stroke. Following damage, the nervous system is able partially to compensate through the formation of alternative connections and pathways, a pr ...
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 16

 TERMINÉ 

European Network for Cell Imaging and Tracking Expertise (ENCITE)

Date du début: 1 juin 2008, Date de fin: 30 nov. 2012,

"Cell therapy can be defined as the transplantation of living cells for the treatment of medical disorders. Three different principles underlie the increasing interest in cell therapy. 1. Transplanted cells used as an “active drug” 2. Transplanted cells used to replace damaged and degenerated tissue. 3. Cells used as a drug delivery vehicle. Promising results have been obtained in pre-clinical and ...
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 30

 TERMINÉ 

Evolving Platform for Improving Living Expectation of Patients Suffering from IctAl Events (EPILEPSIAE)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2011,

Epilepsy is the commonest serious brain disorder in every country, and probably the most universal of all medical disorders. In Europe six million people currently have epilepsy and fifteen million will have epilepsy at some time of their lives. Currently nearly 30% of these people cannot be treated by therapeutics based on pharmacological anticonvulsive medication or resective surgery and are com ...
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 7

 TERMINÉ 

Design of a vaccine to immunize neonates against GBS infections through a durable maternal immune response (DEVANI)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2011,

"Direct vaccination cannot prevent diseases that affect neonates in the first days of life. Group B Streptococcus (GBS) is the major cause of neonatal septicemia and meningitis affecting up to one in every thousand live births. Over 80% of cases occur in the first 7 days after birth and the remaining 20% of disease occurs between 8-90 days after birth. Studies carried out in the USA indicate that ...
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 10

 TERMINÉ 

Targeting alpha-particle emitting radionuclides to combat cancer (TARCC)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2011,

"This project aims at improving drug delivery to cancer cells by developing targeted radiotherapy with alpha-emitting radionuclides. Alpha particles emitted by radionuclides have short tracks (about 100 microns) in body tissues. As a result, they should be most appropriate to treat small-size tumours and isolated cancer cells. This project proposes the development of improved vectors and targeting ...
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 11

 TERMINÉ 

European initiative to improve knowledge, treatment and survival of haemophagocytic syndromes in children (CureHLH)

Date du début: 1 juin 2008, Date de fin: 31 mai 2011,

Haemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening inherited immune disorder of early childhood characterised by an uncontrolled immune response. Three disease causing genes have been identified in about half of the patients. Diagnosis is difficult, pathophysiology poorly understood, and treatment unsatisfactory with about 40% of the children dying from treatment failure or t ...
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 9

 TERMINÉ 

The Pathophysiology and Natural Course of Patients with Primary Antibody Deficiencies (PAD) (EURO-PADnet)

Date du début: 1 mai 2008, Date de fin: 30 avr. 2011,

This medium-sized collaborative project will document and monitor the natural course and study the pathophysiology of Primary Antibody Deficiencies (PAD). PADs are rare inborn errors of the immune system with an estimated incidence of
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 13

 TERMINÉ 

Identification and characterization of novel human telomere-related biomarkers that aid cancer management by improving patient diagnosis, treatment selection, response monitoring, and drug development (TeloMarker)

Date du début: 1 févr. 2008, Date de fin: 31 janv. 2011,

Telomeres are DNA-nucleoprotein structures that protect the ends of human chromosomes through the formation of a ‘cap’ that prevents exonucleolytic degradation, inter- & intra-chromosomal fusion and subsequent chromosomal instability. Telomerase, the ribonucleoprotein enzyme that maintains linear chromosomal DNA ends by the addition of TTAGGG repeats, is completely repressed or present only at low ...
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 8

 TERMINÉ 

"Pathophysiology of rare diseases due to ciliary dysfunction: nephronophthisis, Oral-facial-digital type 1 and Bardet-Biedl syndromes" (EUCILIA)

Date du début: 1 févr. 2008, Date de fin: 31 janv. 2011,

"Primary cilia have been recognized on nearly all-mammalian cells. Emerging data suggest that they act as cellular antennae with diverse motility and sensory functions, detecting a wide variety of signals. As such, defects in cilia formation or function have profound effects on the development of body pattern and the physiology of multiple organ systems. Ciliary defects underlie a wide range of hu ...
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 4