10 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
AnTBiotic – progressing TB drug candidates to clinical proof of concept (anTBiotic)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Tuberculosis (TB) today rivals HIV/AIDS as the leading cause of death from infectious diseases. The number of TB patients has never been higher and the growing proportion of drug-resistant TB is threatening control strategies both in the developing and developed world, Eastern Europe being a particularly worrying point in case. The anTBiotic consortium aims to fuel the long-term TB clinical pipeli ...
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5
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TERMINÉ
Graphene-based disruptive technologies (GrapheneCore1)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,
This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CS ...
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158
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TERMINÉ
Hit to lead optimisation of novel anti-TB scaffolds through an academic-industrial partnership (Coopera-TB)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,
We propose a PhD programme for 4 Early-Stage Researchers (ESR) in tuberculosis (TB) drug discovery. Often associated with poverty, TB is rampant in many parts of Africa and Asia but has now also returned to developed nations. Growing resistance against currently used antibiotics is one of the most pressing problems of the global TB epidemic. Treating TB infections requires a drug cocktail given fo ...
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2
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TERMINÉ
Nanotherapeutics for antibiotic resistant emerging bacterial pathogens (NAREB)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,
Increase in antibiotic resistance is a global concern worldwide. The project NAREB's main objective is the optimization of several nanoformulations of antibacterial therapeutics in order to improve the therapy of multi-drug resistant (MDR) tuberculosis (TB) and MRSA infections in European MDR patients.NAREB will address the problem of drug bioavailability inside the infected macrophages, transport ...
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16
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TERMINÉ
Model-based preclinical development of anti-tuberculosis drug combinations (PREDICT-TB)
Date du début: 1 mai 2012, Date de fin: 30 oct. 2017,
Drug development in TB requires new integrated methods to transition the novel combination regimens needed to shorten first-line therapy and combat multi-drug resistance. Although new agents are emerging, the path to registration of such regimens remains uncertain while capacity for pivotal trials is limited. Selection and optimization of drug combinations for development depends on preclinical sy ...
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23
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TERMINÉ
Medicinal Chemistry Open Innovation Doctorates (OpenMedChem)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,
The establishment of influential public and private public partnerships fostering true collaboration between big Pharma and universities for a non-profit end goal has opened the door for stronger interaction and integration. This structural change has come to stay and is slowly permeating other sectors in which the commercial return on investment is clear (Drug. Discov. Today, 2009, 14, 1003). Thi ...
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2
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TERMINÉ
A systematic analysis of parasite metabolism - from metabolism to intervention (ParaMet)
Date du début: 1 juin 2012, Date de fin: 31 mai 2016,
Parasites exact a devastating toll on health and economic productivity, infecting man and also domestic livestock. Drugs used to combat parasitic diseases are deficient in many ways and new, better drugs are needed to establish sustainable means to combat diseases caused by protozoan parasites that include malaria, trypanosomiasis and leishmaniasis in man, and coccidiosis among others in animals. ...
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12
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TERMINÉ
Training Network on Zebrafish Infection Models for Pharmaceutical Screens (FishForPharma)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
Infectious diseases caused by pathogenic micro-organisms are major causes of death, disability, and social and economic disruption for millions of people. During evolution these pathogens have developed intricate strategies to manipulate host defence mechanisms and outwit the immune system. To reduce the burden of infectious diseases it is important to increase understanding of these host-pathogen ...
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10
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TERMINÉ
European Research Training in the Ubiquitin Proteasome System (UPStream)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
The main objective of the international training network UPStream is the training of a novel generation of European scientist in a critical and complex field of modern biology: the understanding of the regulation of the UPS and its potential use for drug development. The importance of this process is illustrated by the imperious necessity to destroy certain proteins during several phases of the ce ...
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10
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TERMINÉ
Open Collaborative Model for Tuberculosis Lead Optimisation (ORCHID)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2015,
"Early stage Drug Discovery efforts over the last 5 years have resulted in the identification of a number of promising lead compounds in the fight against TB. These leads need to be further progressed and optimised into candidates for pre-clinical development through the Drug Development progression cascade.Three compound families are of particular interest: 1) InhA Inhibitors, 2) New potent whole ...
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