5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH)
Date du début: 1 juin 2015, Date de fin: 30 nov. 2020,
The problem: finding the right patient for the right treatmentDespite a large and growing disease burden in osteoarthritis (OA), many pharmaceutical companies have de-emphasized or even abandoned OA drug development due to perceived hurdles. Crucial in this is the lack of appropriate outcome measures that can robustly identify patient benefit from a specific therapy. The lack of specific and sensi ...
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25
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TERMINÉ
Role of the exon junction complex in the splicing of heterochromatic transcripts (EJC_SPLIC_HET)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,
"Pre-mRNA splicing is an essential function in virtually all eukaryotic organisms. In the human genome, 95% of the genes with multiple exons are subjected to alternative splicing, increasing the diversity of the transcriptome and ensuring the complexity of the organism. Because of its prevalence in many physiological functions splicing mis-regulation has been linked to a large number of diseases, ...
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1
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TERMINÉ
Genomic Targets and Function of Topoisomerase II isoforms during Stem Cell Differentiation (topochromstem)
Date du début: 1 sept. 2012, Date de fin: 31 août 2016,
Topoisomerases are enzymes that solve topological problems arising from DNA templated processes such as replication, transcription, recombination and chromatin remodeling. The type II subfamily of Topoisomerases achieve this task by passing a region of duplex from the same or a different molecule through a double-stranded gap generated in DNA. Mammalian cells encode two isoforms of type II enzymes ...
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1
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TERMINÉ
Epigenetic Regulation of Ageing (EpiAge)
Date du début: 1 août 2012, Date de fin: 31 juil. 2016,
Ageing is certainly one of the most interesting but less understood processes of multi-cellular organisms. Although in the last decade great advances have been made to understand the molecular mechanism of ageing a unifying model is still elusive. Research in C. elegans has focussed on the characterization of signalling pathways involved in ageing. It is was demonstrated that the gene expression o ...
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1
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TERMINÉ
FUNCTIONS OF CHROMATIN MARKS IN REGULATION OF GENE EXPRESSION (FAME)
Date du début: 1 mars 2013, Date de fin: 29 févr. 2016,
In multicellular organisms, during embryogenesis and tissue homeostasis the differentiation of pluripotent stem cells into a variety of specialized cell types is governed by diverse transcriptional programs, the establishment and maintenance of which rely on epigenetic mechanisms, such as chromatin modifications. Over the past years, a large number of post-translational modifications of histones a ...
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