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13 projets européens trouvés

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 EN COURS 
Research on anticancer therapies has provided little progress towards improved survival rates for patients with metastatic disease. The intrinsic advantages of polymer conjugates can be optimised to rationally design targeted combination therapies, concept I pioneered that allows enhanced therapeutic efficiency. Early clinical trials involving conjugates showed activity in chemotherapy refractory ...
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 1

 TERMINÉ 

Exploiting Protein Complexes that Induce Cell-death (EPIC)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The formation of specific protein complexes are key events in life-and-death decisions made by cells. Inappropriate decisions underpin a plethora of disease conditions from degenerative diseases to cancer while the role of the complexes in these processes make them important therapeutic targets. Our ability to develop small molecules to target death-inducing protein complexes has been hampered by ...
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 5

 TERMINÉ 
The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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 47

 TERMINÉ 

Developing an European American NGS Network (DEANN)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

The DEANN project is a network formation initiative that involves six research institutions and universities from four EU countries and equivalently, six research entities from four Latin American countries. The overall goal is to strengthen research partnership among the participants by developing a shared scientific knowhow in the field of Next Generation Sequencing data analysis. More specific ...
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 7

 TERMINÉ 

Machine Learning for Personalized Medicine (MLPM2012)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

"Over the last decade, enormous progress has been made on recording the health state of an individual patient down to the molecular level of gene activity and genomic information – even sequencing a patient’s genome for less than 1000 dollars is no longer an unrealistic goal. However, the ultimate hope to use all this information for personalized medicine, that is to tailor medical treatment to th ...
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 11

 TERMINÉ 
Against the background of the European Innovation Partnership on Active & Healthy Ageing, SmartCare aims to define a common set of standard functional specifications for an open ICT platform enabling the delivery of integrated care to older European citizens. A total of 24 regions and their key stakeholders will define a comprehensive set of integration building blocks around the challenges of dat ...
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 46

 TERMINÉ 

European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR)

Date du début: 1 mars 2012, Date de fin: 30 juin 2016,

Diabetic retinopathy (DR), the leading cause of blindness among working-age individuals in developed countries has been classically considered to be a microcirculatory disease of the retina. However, there is growing evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of DR. For this reason, it is reasonable to hypothesize that therapeutic strategies based on n ...
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 18

 TERMINÉ 

Developmental neurotoxicity assessment of mixtures in children (DENAMIC)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

Various recent epidemiological studies have indicated that exposure to low doses of environmental biologically active contaminants during human development can alter gene expression and have deleterious effects on cognitive development in childhood. The DENAMIC project is ultimately focused on reducing such effects of environmental contamination on learning and developmental disorders in children. ...
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 18

 TERMINÉ 
Users of NGS technologies, producing large and numerous distinct types of omics data, demands statistical methods to combat data and knowledge fragmentation and inappropriate procedures for data analysis. Yet, the current a gap between the available tools for analysis of a single omics data-type versus the requirement of biomedical scientists to understand the integrated results derived from sever ...
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 11

 TERMINÉ 
Transplantation of donor hepatocytes has become an alternative to liver transplantation for the treatment of liver diseases. However, in addition to the complication imposed by severe shortage of donor livers, adult hepatocytes cannot be expanded in vitro. Autologous transplantation of genetically corrected hepatocytes represents another strategy as it circumvents the need for immunosuppression bu ...
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 7

 TERMINÉ 

Light-based functional in vivo monitoring of diseases related enzymes (LIVIMODE)

Date du début: 1 nov. 2009, Date de fin: 30 avr. 2013,

"LIVIMODE aims to develop specific tools for non invasive in vivo imaging of disease related molecular events. Such tools are of high relevance for disease detection, staging, developing animal models of human disease, and evaluating novel therapies. We propose to use optical imaging, which is optimally suited for this task as it provides excellent sensitivity and allows visualizing molecular even ...
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 13

 TERMINÉ 
"The liver is associated with many types of diseases which can only be treated by Orthotopic liver transplants. However, shortage of organ donors represents a major limitation for wide-application of this therapy. Additionally, expansion of fully-functional hepatocytes in vitro remains an important challenge for the drug discovery industry. Human Embryonic Stem cells (hESCs) offer a promising new ...
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 7

 TERMINÉ 
Human Embryonic Stem Cells (hESCs) harbour the extraordinary ability to self-renew and differentiate into cells of all tissue types and thus, hold great promise for the treatment of a range of diseases. Mechanisms controlling hESC fate are yet to be elucidated but are believed to involve regulation by intrinsic and extracellular metabolic factors including hormones, growth factors and small cell-p ...
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 1