12 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century (EU-ToxRisk)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2021,
The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemi ...
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43
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TERMINÉ
Studying, Measuring and Altering Consciousness through information theory in the electrical brain (LUMINOUS)
Date du début: 1 mars 2016, Date de fin: 31 août 2019,
What is consciousness? Can it be measured? While humankind has struggled with these questions for millennia, our project will focus on more modest but nonetheless ambitious and related goals. Inspired by recent developments in neuroscience and the potential role of fundamental concepts such as information integration and algorithmic complexity, we will study, model, quantify, and alter observable ...
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8
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TERMINÉ
Dopamine and Bone Metabolism in Rheumatoid Arthritis (DeBoRA)
Date du début: 1 sept. 2016, Date de fin: 31 août 2018,
Rheumatoid arthritis (RA) is associated with local bone erosion and systemic osteoporosis, which leads to severe disability and low quality of life. Although treatment with biologics can reduce bone loss by inhibiting inflammation, biologics are not able to achieve bone repair and some patients do not respond sufficiently to the treatment. Therefore, an efficient long-term therapeutic approach to ...
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1
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TERMINÉ
Predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures (NOTOX)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,
"NOTOX will develop and establish a spectrum of systems biological tools including experimental and computational methods for i) organotypic human cell cultures suitable for long term toxicity testing and ii) the identification and analysis of pathways of toxicological relevance. NOTOX will initially use available human HepaRG and primary liver cells as well as mouse small intestine cultures in 3D ...
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13
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TERMINÉ
Detection of endpoints and biomarkers of repeated dose toxicity using in vitro systems (DETECTIVE)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,
"Assessment of repeated dose toxicity is a standard requirement in human safety evaluation and relies on animal testing as no alternatives are currently accepted for regulatory purposes. An integrated research strategy for the replacement of animal tests needs to comprise the development of biomarkers of long-term toxicity in human target cells. To this aim, the DETECTIVE project will set up a scr ...
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15
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TERMINÉ
The Body-on-a-Chip (BoC) (BOC)
Date du début: 1 juin 2012, Date de fin: 31 mai 2015,
High attrition and failures rates in pharmaceutical and biotechnological drug development require a paradigm change towards more physiological human cell-based assays at an early time point in the process. The central idea of this proposal is to develop a versatile and reconfigurable pharmaceutical screening technology platform that relies on organotypic three-dimensional spherical microtissues. T ...
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5
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TERMINÉ
Drivers' behavioural adaptation over the time in response to ADAS use (ADAPTATION)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2013,
The objective of ADAPTATION is to improve the career perspectives of young researchers by taking part in an innovative European research programme aiming at investigating drivers' behavioural adaptation and its underlying processes over the time in response to Advanced Driver Assistance Systems (ADAS) use. The research programme integrates, under a joint theoritical framework and a joint longitudi ...
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10
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TERMINÉ
Embryonic Stem cell-based Novel Alternative Testing Strategies (ESNATS)
Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,
"ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to ...
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34
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TERMINÉ
Community Oriented Solutions to Minimise aircraft noise Annoyance (COSMA)
Date du début: 1 juin 2009, Date de fin: 31 mars 2013,
"COSMA aims to develop engineering criteria for aircraft design and operations in order to reduce the annoyance within airport communities due to aircraft exterior noise. By today, such criteria do not exist since aircraft noise engineering has historically focused on achieving ever lower noise levels for individual events and at close distance from the runway. Within the frame of a unique approac ...
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21
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TERMINÉ
European Network on Noise And Health (ENNAH)
Date du début: 1 sept. 2009, Date de fin: 31 janv. 2012,
"This proposal puts forward plans to establish a research network of experts on noise and health in Europe. This network will establish future research directions and policy needs in Europe. The network will review the existing literature on environmental noise exposure and health focussing on the consolidation of existing state of the art knowledge and the identification of gaps in the evidence a ...
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37
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TERMINÉ
HUman behavioral Modeling for enhancing learning by Optimizing hUman-Robot interaction (HUMOUR)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2011,
Description
Investigating and developing efficient robot strategies to facilitate the acquisition of motor skills
The HUMOUR project will investigate and develop efficient robot strategies to facilitate the acquisition of motor skills. It will address both the (human) trainee and the (robot) train ...
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7
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TERMINÉ
"Mathematical modelling of beta-catenin and ras signalling in liver and its impact on proliferation, tissue organization and formation of hepatocellular carcinomas" (CANCERSYS)
Date du début: 1 nov. 2008, Date de fin: 31 oct. 2011,
"The goal of the CANCERSYS project is to establish a multi-scale model for two major signalling pathways involved in the formation of hepatocellular carcinoma, the beta-catenin and ras signalling pathways. Integrative studies linking measurements in primary heptocytes with effects at the organ level will address the impact of these signalling networks on proliferation, tissue organization and form ...
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