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11 projets européens trouvés

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 TERMINÉ 

Clonidine for Sedation of Paediatric Patients in the Intensive Care Unit (CloSed)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

The majority of critically ill children admitted to Paediatric Intensive Care Units (PICU) will require sedation and analgesia which is commonly achieved with a combination of an benzodiazepine and an opioid. However, these agents have a significant side-effect profile, including tolerance, withdrawal and respiratory/circulatory depression. Clonidine is commonly used for sedation in PICU and recom ...
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 10

 TERMINÉ 

WNT-mediated signal relay in stem cells and oncogenesis - from basic biology to applications (WntsApp)

Date du début: 1 août 2013, Date de fin: 31 juil. 2017,

The ITN WntsApp is organized to achieve 3 key aims: (i) Provide a committed training programme for young researchers to bridge the gap between basic scientific knowledge and drug development, (ii) Centring research on a key cancer-signalling pathway, WNT signalling, to stimulate synergies and (iii) Strengthening the link between international partners and private enterprises to stimulate innovatio ...
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 10

 TERMINÉ 

Mechanism-Based Integrated Systems for the Prediction of Drug-Induced Liver Injury (MIP-DILI)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

...e ‘MIP-DILI’ project will address this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological relevance to DILI in humans. An iterative, tiered approach with respect to test compounds, test systems, bioanalysis and systems analysis will be adopted to evaluate existing models and develop new models th ...
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 29

 TERMINÉ 

Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation (INFRAFRONTIER-I3)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:• Develop a series of mutant alleles for every gene in the mouse genome• Determine the phenotypic consequences of each mutation• Identify mouse models for the complete dise ...
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 24

 TERMINÉ 

Drug adverse reactions predictability: exploring the mechanisms underlying the unexplained interindividual differences in drug metabolism and transport (DARMEC)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

...l of human liver in comparison to transcriptome and phenotype data obtained from a bank of 130 human livers with the following AIMS:AIM1: to unmask the epigenetically regulated ADME genesAIM2: to evaluate the epigenetically regulated ADME genes as interindividual variability biomarkersA list of epimarks of interindividual variation of drug ADME processes will be generated.AIM3: to test the epigene ...
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 1

 TERMINÉ 

Mechanisms of skeletal muscle adaptation to exercise and their implications in health and disease (MUSC ADAP XRCS)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"Sedentary lifestyles have led to the increase of obesity, type 2 diabetes, and sarcopenia (decreased muscle mass) of the elderly. Skeletal muscle plays a key role in these conditions, and it is clear that exercise can be as effective as medication in treating some of these ailments. The adaptation of muscle to exercise involves the coordinated regulation of gene networks, whose products adapt mus ...
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 1

 TERMINÉ 

Epigenetic mechanisms underlying inter-individual differences in drug response and hepatic disease (INTERDRUG)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2016,

Inter-individual differences in reaction to drugs and pharmacological treatments can cause severe adverse drug reactions (ADRs) and are a common reason of withdrawal of drugs from the market. ADRs are as costly for society as treatment itself and are a major cause of hospitalizations and deaths. Genetic polymorphisms in genes encoding enzymes involved in drug metabolism can only explain a small su ...
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 1

 TERMINÉ 

Stem Cells for Relevant Efficient Extended and Normalized Toxicology (SCR&TOX)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

... with biological and technological resources to meet that goal. In order to demonstrate the value of pluripotent stem cells for toxicology, the consortium will focus on four complementary aspects: Relevance –i.e. establishing and maintaining discrete cell phenotypes over long-term cultures; providing large versatility to adapt to assays of specific pathways. Efficiency –for i) automated cell produ ...
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 16

 TERMINÉ 

Predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures (NOTOX)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

...including experimental and computational methods for i) organotypic human cell cultures suitable for long term toxicity testing and ii) the identification and analysis of pathways of toxicological relevance. NOTOX will initially use available human HepaRG and primary liver cells as well as mouse small intestine cultures in 3D systems to generate own experimental data to develop and validate predic ...
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 13

 TERMINÉ 

Discovery of Type 2 Diabetes Targets (ICEBERG)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,

This proposal is focused on the identification and biological validation of the metabolic pathways and key regulatory genes that control insulin sensitivity in Type 2 diabetes mellitus (T2DM). We are focusing on skeletal muscle because it is quantitatively the most important tissue involved in maintaining glucose homeostasis under insulin-stimulated conditions and it is a major site of insulin res ...
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 1

 TERMINÉ 

Role of spinal anti-inflammatory lipid mediators in inflammation and arthritis-induced pain (InflammationPain)

Date du début: 4 août 2008, Date de fin: 3 août 2012,

More than 100 million Europeans are affected by arthritis and other rheumatic diseases that cause stiffness, inflammation and swelling in the joints. Notably, pain is one of the most bothersome symptoms reported by this group of people. Pain not only impairs the ability to function and reduces the quality of life, but also forms the basis for an increasing economical burden. According to the Europ ...
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 1