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Plus de 40 projets européens trouvés

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 TERMINÉ 

Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine (MultipleMS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

...plex gene-lifestyle background and broad clinical spectrum with heterogeneity in treatment response.MultipleMS therefore goes significantly beyond current state-of-the-art thereby broadly affecting European policies, healthcare systems, innovation in translating big data and basic research into evidence-based personalized clinical applications.
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 25

 TERMINÉ 

Cell division and the origin of embryonic aneuploidy in preimplantation mouse development (COREMA)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Cell division is fundamental for development. In the early mammalian embryo it drives the rapid proliferation of totipotent cells, the basis for forming the fetus. Given its crucial importance, it is surprising that cell division is particularly error-prone at the beginning of mammalian life, resulting in spontaneous abortion or severe developmental retardation, the incidence of which is increasin ...
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 1

 TERMINÉ 

An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century (EU-ToxRisk)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2021,

The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemi ...
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 43

 TERMINÉ 

GALAXY: Gut-and-liver axis in alcoholic liver fibrosis (GALAXY)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2021,

Alcohol overuse is an important societal challenge with annual healthcare costs of over €22 billion in Europe. Alcohol is the main cause of liver cirrhosis, which is the 5th and 7th most common cause of life years lost in respectively Eastern and Western Europe. Cirrhosis is considered irreversible but its precursor, liver fibrosis, is reversible when detected before disease progression. GALAXY pr ...
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 12

 TERMINÉ 

Structural basis for the coordination of chromosome architecture by condensin complexes (CondStruct)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

Chromosomes undergo dramatic changes in their three-dimensional organisation during all aspects of genome function, ranging from the regulation of gene expression during cellular differentiation to chromosome duplication and partitioning over the course of a cell division cycle. The multi-subunit condensin protein complex plays major roles for these changes in DNA topology. Despite its fundamental ...
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 1

 TERMINÉ 

Exploring the human gut microbiome at strain resolution (MicrobioS)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

With the genome sequencing of hundreds of bacterial isolates per day and a vast and growing number of metagenomic sequencing projects on gut microbiomes in healthy and diseased people all over the world, it becomes feasible to explore the microbial diversity in us not only at the level of genera and species, but at strains. As two different strains of a prokaryotic species might only share 40% of ...
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 1

 TERMINÉ 

Towards enduring mouse resources and services advancing research into human health and disease (INFRAFRONTIER2020)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
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 33

 TERMINÉ 

Re(defining) CD4+ T Cell Identities One Cell at a Time (ThDEFINE)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

The immune system consists of a complex continuum of cell types that communicate with each other and non-immune tissues in homeostasis, and during infections, autoimmunity and cancer. Conventional transcriptional and functional profiling enabled by cell surface marker sorting has revealed a great deal about how specific cell types operate en masse, yet important transcriptional heterogeneity that ...
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 1

 TERMINÉ 

EMBL Interdisciplinary, International and Intersectorial Postdocs (EI3POD)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2020,

The EIPOD programme was developed in 2007 with the objective of making use of the excellent scientific environment available at EMBL to support an innovative fellowship programme focused on interdisciplinary research training for postdoctoral fellows. EI3POD is designed to enrich and significantly build upon the very successful EIPOD programme and bears a significant number of novel features for s ...
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 1

 TERMINÉ 

Unraveling Principles of PDZ-mediated Cell Signaling (PDZnet)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

PDZnet will create an innovative European PhD training network focusing on unraveling PDZ domain-mediated signaling networks. The emphasis will be on signaling nodes essential for the development of cancer and diseases of the nervous system, conditions that affect millions of Europeans and are major societal challenges. PDZ domains are protein and lipid recognizing modules that play a central role ...
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 10

 TERMINÉ 

Structure and mechanism of viral and cellular membrane fusion machineries (MEMBRANEFUSION)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Fusion of two biological membranes is essential to life. It is required during organism development, for trafficking of material between cellular compartments, for transfer of information across synapses, and for entry of viruses into cells. Fusion must be carefully controlled and the core fusion components are typically found within a complex regulatory machine. There have been decades of researc ...
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 1

 TERMINÉ 

Oscillatory signaling dynamics – a quantitative approach to reveal their origin and function in development (Oscillations)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

This project aims to reveal the origin and principal functions of spatiotemporal signalling oscillations in the context of embryonic development. Vertebrate embryo segmentation offers a particularly suitable context to study an assembly of ultradian, genetic oscillators, which in addition, exhibit striking synchronization that generates periodic, wave-like patterns. Using the mouse model, in which ...
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 1

 TERMINÉ 

Next generation single molecule protein fluorescence (SMPFv2.0)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Fluorescence techniques provide powerful means to study single protein machineries. Single molecule observation of Fluorescence Resonance Energy Transfer (FRET) has become an important tool for probing structure, distances, dynamics, physicochemical properties and size of purified (in vitro) protein complexes. Super-resolution techniques provide complementary spatial information about proteins in ...
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 1

 TERMINÉ 

A multidisciplinary approach to cell division: From human oocyte to synthetic biology (DivIDe)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2020,

The cell is the universal unit of living matter, and there cannot be propagation of life without cell division. DivIDe aims to investigate the mechanisms and principles of cell division and to reproduce them in vitro with synthetic approaches. Crucial to cell division is the mitotic spindle, a structure whose main duty is the separation of chromosomes. The spindle is made of microtubules (MT), mol ...
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 9

 TERMINÉ 

Dissecting the functional importance of eukaryotic protein phosphorylation (PhosFunc)

Date du début: 1 avr. 2015, Date de fin: 31 mars 2020,

Cells have evolved intricate systems to sense environmental changes and an initial response to such cues is often driven by post-translational modifications (PTMs) of proteins. Protein phosphorylation is an abundant PTM that modulates protein function via diverse mechanisms. Improvements in mass-spectrometry are unveiling a complex world of PTM regulation with thousands of phosphosites routinely i ...
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 1

 TERMINÉ 

Muscle Stress Relief: An integrated research program linking together basic research on secondary myopathies in stress states to innovative translation in applied myology. (Muscle stress relief)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

...ires a multidisciplinary approach covering aspects of ageing, metabolism, and on the humoral cross-talk of muscle with other key organs including heart, liver, kidney, and lung. To achieve this, six European groups with complementary expertise in inter-organ-cross-talk during stress-induced secondary myopathies will team-up with a leading team in the U.S. with expertise in the translation of musc ...
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 14

 TERMINÉ 

Bioinformatics Services for Data-Driven Design of Cell Factories and Communities (DD-DeCaF)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

Omics data is not leveraged effectively in the biotechnology industry due to lack of tools to rapidly access public and private data and to design cellular manipulations or interventions based on the data. With this project we aim to make a broad spectrum of omics data useful to the biotechnology industry covering application areas ranging from industrial biotechnology to human health. We will dev ...
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 10

 TERMINÉ 

Innovative Management of Genetic Resources (IMAGE)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

This aim of IMAGE is to enhance the use of genetic collections and to upgrade animal gene bank management. IMAGE will better exploit DNA information and develop methodologies, biotechnologies, and bioinformatics for rationalising animal genetic resources. It will demonstrate the benefits brought by gene banks to the development of sustainable livestock systems by: enhancing the usefulness of genet ...
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 28

 TERMINÉ 

CellViewer: super-resolution systems microscopy to assess pluripotency and differentiation of stem cells at single cell level (CellViewer)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2020,

In this ambitious and multi-disciplinary proposal, we aim to develop new technologies that will allow us to visualize in single cells, in parallel and at the systems level, DNA, mRNAs and proteins with nanoscale resolution. We will refer to these novel technologies as the ‘CellViewer’: a unique cutting-edge high-throughput super-resolution (SR) microscopy approach (including new hardware and softw ...
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 6

 TERMINÉ 

COllaborative Management Platform for detection and Analyses of (Re-)emerging and foodborne outbreaks in Europe (COMPARE)

Date du début: 1 déc. 2014, Date de fin: 30 nov. 2019,

COMPARE aims to harness the rapid advances in molecular technology to improve identification and mitigation of emerging infectious diseases and foodborne outbreaks. To this purpose COMPARE will establish a “One serves all” analytical framework and data exchange platform that will allow real time analysis and interpretation of sequence-based pathogen data in combination with associated data (e.g. c ...
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 32

 TERMINÉ 

European Network linking informatics and genomics of helper T cells (ENLIGHT-TEN)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2019,

ENLIGHT-TEN is a European Network Linking Informatics and Genomics of Helper T cells: our mission is to provide cross-disciplinary training in cellular immunology and big data analysis such that we train a new generation of researchers to fully exploit the power of emerging technological platforms. Our network of TEN beneficiaries combines T cell expertise with state-of-the-art technologies such a ...
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 11

 TERMINÉ 

Reseach Infrastructures Training Programme (RItrain)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

There has never been a greater need for skilled managers and operators of research infrastructure (RI). Europe must develop the workforce that will turn ~50 nascent RIs with sites in different countries into powerhouses of support for major projects comparable to understanding the blueprint of life or discovering new subatomic particles. RItrain will develop a flagship training programme enabling ...
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 13

 TERMINÉ 

Infrastructure for NMR, EM and X-rays for translational research (iNEXT)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

... novel biomaterials.iNEXT (infrastructure for NMR, EM and X-rays for Translational research) will provide high-end structural biology instrumentation and expertise, facilitating expert and non-expert European users to translate their fundamental research into biomedical and biotechnological applications. iNEXT brings together leading European structural biology facilities under one interdisciplina ...
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 23

 TERMINÉ 

ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. (ELIXIR-EXCELERATE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

...ing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that science can currently imagine, with ...
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 47

 TERMINÉ 

Coordinated Research Infrastructures Building Enduring Life-science services (CORBEL)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

... as biobank samples, imaging facilities, molecular screening centres or animal models. Through a user-led approach CORBEL will develop the tools, services and data management required by cutting-edge European research projects: collectively the BMS RIs will establish a sustained foundation of collaborative scientific services for biomedical research in Europe and embed the combined infrastructure ...
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 39

 TERMINÉ 

European Marine Biological Research Infrastructure Cluster to promote the Blue Bioeconomy (EMBRIC)

Date du début: 1 juin 2015, Date de fin: 31 mai 2019,

...s, practical and cultural difficulties in connecting science with industry, and high fragmentation of regional research, development and innovation (RDI) policies. To overcome these barriers, EMBRIC (European Marine Biological Resource Infrastructure Cluster) will link biological and social science research infrastructures (EMBRC, MIRRI, EU-OPENSCREEN, ELIXIR, AQUAEXCEL, RISIS) and will build inte ...
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 27

 TERMINÉ 

Research Infrastructures for Phenotyping, Archiving and Distribution of Mouse Disease Models - Promoting International Cooperation and User Engagement to Enhance Biomedical Innovation (IPAD-MD)

Date du début: 1 juin 2015, Date de fin: 31 mai 2019,

The IPAD-MD project addresses cooperation and coordination between the pan-European INFRAFRONTIER Research Infrastructure and complementary research infrastructures in America, Asia and Australia, contributing to the global effort of the International Mouse Phenotyping Consortium (IMPC). In order to increase the reach of INFRAFRONTIER, IPAD-MD will also reach out to complementary infrastructures a ...
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 11

 TERMINÉ 

Environmental Research Infrastructures Providing Shared Solutions for Science and Society (ENVRI PLUS)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

...r environmental RI communities. The produced solutions, services and other project results are made available to all environmental RI initiatives, thus contributing to the development of a consistent European RI ecosystem.
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 37

 TERMINÉ 

Authentication and Authorisation For Research and Collaboration (AARC2)

Date du début: 1 mai 2017, Date de fin: 30 avr. 2019,

...C2 will work with existing e-infrastructures and ESFRI projects to deploy and enhance (JRA1) the integrated AAI (built on eduIGAIN and federated access) delivered by AARC (obj1–Development of a pan-European identity federation)- Use-cases that meet integration (accessing services offered by multiple e-infrastructures) and data-rich aspects included in AARC2 (SA1). AARC2 will work to enable federat ...
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 26

 TERMINÉ 

Functional wiring of the core neural network of innate fear (COREFEAR)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

Fear is an emotion that exerts powerful effects on our behavior and physiology. A large body of research implicates the amygdala in fear of painful stimuli, but virtually nothing is known about the circuits that support fear of predators and social threats, despite their primal importance in human behavior and pathology. Unlike painful stimuli, predator and social threats activate the medial hypot ...
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 2

 TERMINÉ 

Structure-function studies of the general transcription factor IIIC (TFIIIC) (TF3C_EM)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2019,

Transfer RNAs (tRNAs) act as adaptor molecules, decoding messenger RNA and delivering the correct amino acid to the growing peptide chain. Being instrumental in the cellular translation machinery, it is important to understand their synthesis mechanism. In eukaryotes, tRNA gene (tDNA) transcription begins with transcription factor IIIC (TFIIIC) bound to 2 gene-internal promoter elements, A- and B- ...
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 1

 TERMINÉ 

Dynamic architecture of the RNA polymerase I transcription initiation machinery (POL1PIC)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

RNA polymerase (Pol) I and Pol III synthesize non-translated RNAs including rRNA, 5S RNA, and tRNAs for ribosome assembly and protein synthesis. Pol I and Pol III transcription initiation machineries are carefully regulated in healthy cells, while misregulation of Pol I and Pol III transcription is observed in a variety of cancers. We propose to study the structure and dynamics of the Pol I transc ...
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 1

 TERMINÉ 

Competitive assembly dynamics of the DCC receptor with its guidance cues integrates signals for cellular steering (GUIDESIGINT)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2019,

Secreted proteins and their receptors underlie the communication networks of multicellular organisms and guide the proper organization of developing tissue. An essential process involves the human transmembrane receptor and signal integration hub, Deleted in Colorectal Cancer (DCC). Emerging evidence indicates that the netrin and draxin guidance cues are secreted by neighboring cells and form comp ...
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 1

 TERMINÉ 

Dissecting the Molecular Mechanism of Catastrophic DNA Rearrangement in Cancer (CHROMOTHRIPSIS)

Date du début: 1 avr. 2014, Date de fin: 31 janv. 2019,

Recent cancer genome analyses have led to the discovery of a process involving massive genome structural rearrangement (SR) formation in a one-step, cataclysmic event, coined chromothripsis. The term chromothripsis (chromo from chromosome; thripsis for shattering into pieces) stands for a hypothetical process in which individual chromosomes are pulverised, resulting in a multitude of fragments, so ...
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 1

 TERMINÉ 

The European Open Science Cloud for Research Pilot Project. (EOSCpilot)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2018,

The EOSCpilot project will support the first phase in the development of the European Open Science Cloud (EOSC) as described in the EC Communication on European Cloud Initiatives [2016]. • It will establish the governance framework for the EOSC and contribute to the development of European open science policy and best practice; • It will develop a number of pilots that integrate service ...
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 39

 TERMINÉ 

Predictive modelling of 3D genome topology during progressive stages of embryonic development (4DGenomeReg)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2018,

The mechanisms that regulate genome activation and gene expression occur within a complex three-dimensional (3D) architecture, that helps bring functional regulatory elements into spatial proximity. Although observed at individual loci, the general principles and dynamics of enhancer-promoter interactions remain very poorly understood. The proposed project will use chromosome conformation capture, ...
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 1

 TERMINÉ 

Medical Genomics and Epigenomics Network (MEDGENET)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

The main goal of MEDGENET consortium is to use synergies and existing expertise in EU leading institutions such as EMBL, Uppsala University and CERTH to reinforce the productivity and competitiveness of the CEITEC in the field of medical genomics and epigenomics. We propose clear strategy based on combination of unique complementary skills present in partner institutions that will transform CEITEC ...
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 4

 TERMINÉ 

Development of chemical biology tools for the elucidation of protein phosphatase-1 substrates and druggability (PP1TOOLS)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

Protein serine/threonine phosphatases (PSTPs) are considered undruggable although they are involved in the most prominent post-translational modifications. This is mainly due to an apparent lack of substrate specificity. One important PSTP is protein phosphatase-1 (PP1), a ubiquitous PSTP that is predicted to catalyze about 1/3rd of Ser and Thr dephosphorylations in eukaryotic cells, counteracting ...
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 2

 TERMINÉ 

Global BioImaging Project - International imaging infrastructure services for the life science community (Global BioImaging)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2018,

"The EC H2020 funded "Global BioImaging Project" enables Euro-BioImaging, the research infrastructure for access to biological and medical imaging technologies on the ESFRI roadmap, to work together with its international counterparts - the Australian Microscopy and Microanalysis Research Facility (AMMRF), the National Imaging Facility (Australia) and India-BioImaging - on concrete and sustainable ...
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 8

 TERMINÉ 

Centre of Excellence for Biomolecular Research (BioExcel)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2018,

... digital, and this development is accelerating rapidly. Biomolecular modelling techniques such as homology modelling, docking, and molecular simulation have advanced tremendously due to world-leading European research, resulting in extreme demands for better computational performance and throughput as these tools are used in applied research and industrial development. This research has direct inf ...
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 13