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22 projets européens trouvés

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 EN COURS 
Liver cirrhosis is a very common chronic disease and one of the leading causes of death in European. Moreover, cirrhosis has a marked impact in patients quality of life and represents a major burden for health systems. Treatment of cirrhosis is currently based on symptomatic management of complications and has not changed substantially in the last 20 years. There is an unmet need for therapies tha ...
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 18

 EN COURS 
The main goal of HIVACAR proposal is to change the current paradigm of HIV treatment by obtaining a functional cure for HIV (i.e., control of viral load to levels below the threshold of 50 copies/ml and maintenance of high CD4+ T-cell count after discontinuation of antiretroviral therapy) thanks to effectively targeting residual virus replication and viral reservoirs. In order to do so, the planne ...
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 16

 EN COURS 
Current orthopaedic treatments permit spontaneous bone regeneration to unite and heal 90% bone injuries. Non-union associates pain and disability, often requiring biological enhancement. Regenerative medicine research suggests to the general public that alternative treatments based on advanced therapy medicinal products (ATMP) are already available. However, early clinical trials only explore its ...
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 13

 EN COURS 
Chronic aortic aneurysms are permanent and localized dilations of the aorta that remain asymptomatic for long periods of time but continue to increase in diameter before they eventually rupture. Left untreated, the patients’ prognosis is dismal, since the internal bleeding of the rupture brings about sudden death. Although successful treatment cures the disease, the risky procedures can result in ...
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 26

 EN COURS 
Ischemic stroke (IS), caused by occlusion of arteries that supply blood to the brain, remains a leading cause of mortality and morbidity in the world. Disruption of blood and oxygen supply to the brain leads to neuronal death in the ischemic core within minutes. The hypoperfused tissue surrounding the ischemic core, the penumbra, is at high risk for infarction over time but still salvageable. Neur ...
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 13

 EN COURS 
... of production of allogenic cells, automation & EU standardisation. At the end of the RESPINE trial, we aim to propose a broadly available and clinically applicable treatment for DDD, marketed by European SMEs.
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 18

 EN COURS 

Paediatric Clinical Research Infrastructure Network (PedCRIN)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

... needs in terms of trial management capacity. In its 2016 Roadmap, ESFRI suggested an upgrade of ECRIN to develop a common infrastructure for paediatric trial management through cooperation with the European Paediatric Clinical Trial Research Infrastructure (EPCTRI). The resulting PedCRIN project is also a unique opportunity to improve ECRIN business model and financial sustainability, attracting m ...
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 16

 EN COURS 
Spinal cord injury is a severe and devastating neurological disorder that leaves patients with permanent paralysis of the body. No treatment is available today to regenerate interrupted nerve fibers and repair the damaged spinal cord. The incidence of spinal cord injury is about newly injured 10’000 people per year in the EU, and due to an almost normal life expectancy more than 200’000 patients a ...
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 12

 EN COURS 
... festyle) determinants and iii) the effect and mechanisms of action of meditation training, on mental health and wellbeing in older people. This will be achieved by using pre-existing databases from European partners and conducting two randomized controlled trials (Studies 1 and 2B) and one observational study (2A). STUDY 1 will assess the short-term effects of an 8-week meditation intervention (ve ...
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 12

 TERMINÉ 
Every year, 1.3 million Europeans have a stroke and one million ultimately die of stroke. One third of stroke patients remain dependent on the help of others. The annual costs for stroke care in Europe are estimated at € 64.1 billion. Stroke incidence increases almost exponentially with age, and the personal, societal, and economic burden of stroke is therefore largely driven by its frequent occur ...
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 20

 TERMINÉ 
Patients with cardiovascular risk factors, e.g. hypertension and obesity are at risk of developing heart failure with preserved ejection fraction (HFpEF), a highly prevalent disease in the elderly, mostly women population. There is currently no specific, defined treatment for HFpEF, beyond control of risk factors. Activation of cardiac and vascular Beta3-adrenergic receptors (B3AR) represents a ne ...
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 15

 TERMINÉ 
... ine and 40 weeks (i.e. probing the disease-modifying effect only). Potential surrogate radiological and biological biomarkers, health economics and societal impacts will be assessed. 17 national, European and international research and innovation activities will be linked with the project. The study results should prompt academic and industrial research on iron chelation as a disease-modifying tre ...
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 17

 TERMINÉ 
VISION-DMD aims to advance clinical development of the orphan drug VBP15 as a new therapy to revolutionise care for all patients with Duchenne muscular dystrophy (DMD) by 2020, in line with IRDiRC goals. DMD is an incurable, rare muscle wasting disease; boys progressively weaken, lose ambulation and death occurs by early adulthood. Corticosteroids (CS) are widely recognised to increase muscle stre ...
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 8

 TERMINÉ 

European Research Infrastructures in the International Landscape (RISCAPE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

RISCAPE will provide systematic, focused, high quality, comprehensive, consistent and peer-reviewed international landscape analysis report on the position and complementarities of the major European research infrastructures in the international research infrastructure landscape. To achieve this, RISCAPE will establish a close links with a stakeholder panel representing the main user groups of the ...
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 12

 TERMINÉ 

BIOengineered grafts for Cartilage Healing In Patients (BIO-CHIP) (BIO-CHIP)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

Spontaneous healing of articular cartilage injuries is poor and untreated defects predispose to osteoarthritis. Current therapies, including innovative autologous cell-based treatments, cannot predictably and reproducibly restore cartilage structure and function. BIOCHIP will carry out a multicenter, prospective phase II clinical trial to treat knee cartilage injuries using engineered grafts based ...
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 9

 TERMINÉ 

Reseach Infrastructures Training Programme (RItrain)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

There has never been a greater need for skilled managers and operators of research infrastructure (RI). Europe must develop the workforce that will turn ~50 nascent RIs with sites in different countries into powerhouses of support for major projects comparable to understanding the blueprint of life or discovering new subatomic particles. RItrain will develop a flagship training programme enabling ...
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 13

 TERMINÉ 

Coordinated Research Infrastructures Building Enduring Life-science services (CORBEL)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

... as biobank samples, imaging facilities, molecular screening centres or animal models. Through a user-led approach CORBEL will develop the tools, services and data management required by cutting-edge European research projects: collectively the BMS RIs will establish a sustained foundation of collaborative scientific services for biomedical research in Europe and embed the combined infrastructure ...
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 39

 TERMINÉ 
... Europe by enabling early and safe discharge of the majority of patients with an intermediate risk of CAD.To evaluate this, we propose the DISCHARGE project that will be implemented by a multinational European consortium. The core of the project is the DISCHARGE pragmatic randomised controlled trial. The primary hypothesis will be that CT is superior to ICA for major adverse cardiovascular events ( ...
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 38

 TERMINÉ 

The European Open Science Cloud for Research Pilot Project. (EOSCpilot)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2018,

The EOSCpilot project will support the first phase in the development of the European Open Science Cloud (EOSC) as described in the EC Communication on European Cloud Initiatives [2016]. • It will establish the governance framework for the EOSC and contribute to the development of European open science policy and best practice; • It will develop a number of pilots that integrate service ...
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 39

 TERMINÉ 
... 1) the production of consistent batches of high-quality autologous ASCs under GMP-compliant conditions and (2) delivery of these cell doses to patients in a trial which will meet all national and European regulatory and ethical standards and which will have sufficient statistical power to provide an unambiguous and definitive assessment of safety and efficacy.
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 20

 TERMINÉ 

European Consortium for Communicating Stem Cell Research (EuroStemCell)

Date du début: 1 janv. 2015, Date de fin: 31 mars 2018,

The European Consortium for Communicating Stem Cell Research (EuroStemCell) unites 33 partner institutions, that collectively represent >400 stem cell research groupings across Europe. Our common goal is to provide trusted high quality information on stem cells accessible to citizens and stakeholders across Europe, through support and further development of the multi-lingual European Stem Cell Inf ...
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 32

 TERMINÉ 

Innovative PROcurement for Visual Impaired People (PRO4VIP)

Date du début: 1 févr. 2015, Date de fin: 30 nov. 2016,

... cation and an adult’s ability for high quality employment, risk of falls, difficulties with daily living and increased dependence. PRO4VIP project has the objectives of : (1) the creation of an European wide network of procurers (RITT, US, FVG, BFW, AQuAS); (2) the definition of a common innovation procurement roadmap in the short term and in the long term and (3) the definition of the public proc ...
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 14