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Plus de 40 projets européens trouvés

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 TERMINÉ 

Beta Cell Therapy in Diabetes (BETACELLTHERAPY)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,

...that of primary human beta cells following implantation in rodents using a site that is accessible to modulation and monitoring. Third, we will design an antibody-based therapy for inducing immune tolerance to regenerated beta cells and to a beta cell implant. Efficacy, safety and regulatory criteria will be determined for clinical implementation. Clinical protocols will be prepared by adjusting a ...
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 18

 TERMINÉ 

Association of European Marine Biological Laboratories (ASSEMBLE)

Date du début: 1 mars 2009, Date de fin: 31 oct. 2014,

Europe has a very long and distinguished history in Marine Biology and its coastal marine biological stations are the oldest in the world. For example, Stazione Zoologica in Naples (SZN), Station Biologique in Roscoff (SBR) and Kristineberg Marine Research Station in Fiskebäckskil (KMRS) were all established in the late 19th Century. They began an enviable tradition as marine biological research s ...
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 8

 TERMINÉ 

The Reactive Oxygen Signaling Network of Cells (ROnet)

Date du début: 1 janv. 2008, Date de fin: 31 juil. 2014,

...s, will be used to dissect the ROS network of plants. Specific findings will be tested using gain- and loss-of-function mutants. ROS are implicated in diverse biological processes including stress tolerance, aging and cancer. Because the potential risk of oxidative stress is common to all aerobic organisms, elucidating the ROS-signaling network of plants would have a significant impact in medicine ...
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 1

 TERMINÉ 

From Sequence to Consequence - Tools for the Exploitation of Livestock Genomes (Quantomics)

Date du début: 1 juin 2009, Date de fin: 30 nov. 2013,

QUANTOMICS will deliver a step-change in the availability of cutting edge technologies and tools for the economic exploitation of livestock genomes. We will provide the tools to identify rapidly the causative DNA variation underpinning sustainability in livestock and for industry to exploit high-density genomic information. Our adaptable quantitative and genomic tools each based on cutting-edge te ...
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 18

 TERMINÉ 

Open Gromov-Witten theory, real symplectic geometry and mirror symmetry (RealSympOpenMirror)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

A great deal of research in symplectic geometry has revolved around Gromov-Witten invariants, a mathematical model of the physics of closed strings. Recent research in string-theory indicates that there should be an open-string analog of Gromov-Witten invariants, despite certain mathematical complications. In my thesis, I introduced a working definition of open Gromov-Witten invariants for real sy ...
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 1

 TERMINÉ 

Biochemical and behavioral characterization of miRNA-mediated regulation of circadian rhythms in Drosophila (Circadian Rhythms)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

A prominent theme in biology is the mechanism underlying the response of organisms to changes in their environment. miRNAs are small non-coding RNAs that serve as post-transcriptional regulators of gene expression. Translational control by miRNAs is emerging as a major regulatory component of many developmental, physiological and metabolic pathways. However, little is known about their role in be ...
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 1

 TERMINÉ 

Novel Design Principles and Technologies for a New Generation of High Dexterity Soft-bodied Robots Inspired by the Morphology and Behaviour of the Octopus (OCTOPUS)

Date du début: 1 févr. 2009, Date de fin: 31 juil. 2013,

The octopus is a marine invertebrate with amazing motor capabilities and intelligent behaviour. Its body has no rigid structures and has interesting characteristics, from an engineering viewpoint: infinite number of degrees of freedom (dof), bending in many different directions, variable and controllable stiffness, high dexterity, fine manipulation, highly distributed control. The octopus represen ...
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 8

 TERMINÉ 

Shifting the oligomerization equilibrium of proteins: a novel therapeutic strategy (Shiftides)

Date du début: 1 juil. 2008, Date de fin: 30 juin 2013,

The aim of my project is to establish a multidisciplinary platform for quantitative biophysical analysis of protein-protein interactions in health and disease as a basis for drug design: (1) Analyzing protein-protein interactions at the molecular level in healthy systems; (2) Understanding what goes wrong in disease at the molecular level; (3) Development of drugs that will restore the biological ...
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 1

 TERMINÉ 

Planets - The Solar System and Beyond (PLANETARYSYSTEMS)

Date du début: 1 juin 2008, Date de fin: 31 mai 2013,

The discovery of the first extra solar planet, merely twelve years ago, ushered an explosive growth in our knowledge of planetary systems. Extrasolar planets have been detected with ever-smaller masses and today Earth analogs orbiting other stars are on the discovery horizon! Observations of disks around young stars reveal the initial conditions for planet formation while detections of debris disk ...
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 1

 TERMINÉ 

PROteomics SPECification in Time and Space (PROSPECTS)

Date du début: 1 avr. 2008, Date de fin: 31 mars 2013,

"Proteomics is a major new field in biomedical research, which deals with the large-scale identification and characterization of large groups of proteins, or “proteomes”. These can either be the components of a subcellular organelle or compartment, or even the entire protein complement of whole cells and tissues. Proteomics is essential in the functional annotation of the genome and in future atte ...
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 11

 TERMINÉ 

Innovative advanced Wood-based Composite Materials and Components (WOODY)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

Currently the world of polymeric composite materials is almost exclusively based on fossil derived components. This fact represents a strong issue, as the non-renewable global oil resources are being exploited year after year, also as a consequence of the ever growing demand for plastics engineering materials. WOODY Project goal is to develop new composite panels and laminates from wood derived re ...
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 19

 TERMINÉ 

Ethnic Discrimination in Israeli Markets (EDIM)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2012,

"Ethnic tensions and the potential for ethnic discrimination characterize many countries around the world. The aim of the proposed project is to study the extent and the sources of discrimination against Israeli Arabs in online labor, housing, and consumer goods markets. The perception that Israeli Arabs suffer from discrimination is widespread, yet rigorous quantitative economic research on anti- ...
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 1

 TERMINÉ 

Popular Culture and Regionalization in East and Southeast Asia (AsianPopCultures)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2012,

Over the last two decades, Japanese, Chinese, and Korean popular culture products have been massively exported, marketed, and consumed throughout East and Southeast Asia. A wide variety of these products are especially accessible and readily apparent in the region’s big cities. Concurrently, regional collaborations in the production and marketing of movies, music, animation, and television program ...
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 1

 TERMINÉ 

Novel approaches for the development of customized skin treatments and services (Test case: Dead Sea Minerals and Conventional drugs) (Skin Treat)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

Economical and health interests of skin problems are fast growing issues in Europe, following the remarkable extension in life expectancy in western countries, together with the increased awareness of UV radiation risks. Personalized health care approach has been discussed over the past few years and had been accompanied by developing innovative technologies capable of identifying specific biomark ...
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 15

 TERMINÉ 

Long time behavior for motion in random media (MotionRandomMedia)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

Models of random motion in random media have received significant scientific attention in the past 30 years. The interest in these models stems from two main reasons: (1) In physics, most processes of diffusion take place in environments that are not regular. Thus the standard theory of random motion does not necessarily apply to them, and a new methodology needs to be created. (2) These models, d ...
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 1

 TERMINÉ 

The Role of Langerhans Cells in T-Cell Priming During Intradermal Naked DNA Immunization (SkinImmunity)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) that have a dominant role in initiating T-cell responses. The skin is populated by at least two subsets of DCs: Langerhans cells (LCs), which form a contiguous network throughout the epidermis, and dermal DC. According to the conventional paradigm, LCs perform a sentinel function by detecting skin pathogens and integrating this ...
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 1

 TERMINÉ 

Development of a DNA vaccine for visceral leishmaniasis (LEISHDNAVAX)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,

"This project will focus on the preclinical development of a DNA vaccine for human visceral leishmaniasis. The project is based upon the DNA vaccine technology and immunomodulators developed at Mologen AG (Berlin, Germany), which are in clinical development for cancer and 3-5 known antigens that already have demonstrated profiles of protection in animal models of leishmaniasis. Antigens will be se ...
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 8

 TERMINÉ 

EUROPEAN DRUG INITIATIVE ON CHANNELS AND TRANSPORTERS (EDICT)

Date du début: 1 févr. 2008, Date de fin: 30 juin 2012,

"The European Drug Initiative on Channels and Transporters, EDICT, allies for the first time, partners with world-class expertise in both the structural and functional characterisation of membrane channels and transporters. State-of-the-art facilities and personnel for X-ray crystallography, Electron Microscopy and Nuclear Magnetic Resonance and the latest throughput technology, will provide infra ...
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 28

 TERMINÉ 

Genomic determinants of inflammation: from physical measurements to system perturbation and mathematical modeling (Model-In)

Date du début: 1 déc. 2008, Date de fin: 31 mai 2012,

Inflammation is a complex biochemical and cellular response essential for the viability of higher organisms because of its requirement in anti-microbial defence and protection from the consequences of tissue injury. However, uncontrolled or sustained inflammation leads to several diseases with a huge social impact, ranging from autoimmune diseases to septic shock and cancer. While the requirement ...
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 11

 TERMINÉ 

A New Agenda for European Security Economics (EUSECON)

Date du début: 1 mars 2008, Date de fin: 30 avr. 2012,

"EUSECON analyses the newly emerging field of European security economics by identifying the nature and scope of this research field, by bringing together the leading European research players in this field and by building new analytical and conceptual insights on the most pressing research needs in this field. By implementing these research activities, EUSECON will establish an operational networ ...
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 15

 TERMINÉ 

"Contribution of the WW domain-containing oxidoreductase, WWOX, gene toward mammary tumorigenesis" (WOX IN BREAST CANCER)

Date du début: 1 mars 2008, Date de fin: 29 févr. 2012,

"Chromosomal and genomic abnormalities affecting chromosome 16q have frequently been reported in cytogenetic and allelotypic studies of various epithelial tumors, including breast cancer. The WWOX gene has been recently cloned and described. WWOX spans a genomic region of more than 1 MB located in ch. 16q23.1. This specific region is the most frequent target for LOH affecting 16q in breast cancer. ...
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 1

 TERMINÉ 

Characterizing the oncogenic properties and target genes of the splicing factor protooncogene SF2ASF (Oncogenic Splicing)

Date du début: 1 mars 2008, Date de fin: 29 févr. 2012,

Cancer is a multifaceted disease involving numerous mutations in many tumor suppressors and oncogenes. Elucidation of the molecular basis of cancer has been and continues to be a major goal of biomedical research in the past few decades. Previous evidence suggests a connection between alternative splicing and cancer, and the activities of many oncogenes and tumor suppressors are modulated by alter ...
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 1

 TERMINÉ 

The role of striatum in selection of behaviour and motor learning - neuronal code, microcircuits and modelling (Select-and-act)

Date du début: 1 août 2008, Date de fin: 31 janv. 2012,

The input layer of the basal ganglia, the striatum, plays a critical role in the control of motor behaviour and cognitive function. It serves as a filter for cortical and thalamic signals and takes part in determining which actions should be performed at a given instant. Our goal is to define the cellular and network organisation underlying decision-making by analysing the microcircuitry of subpop ...
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 4

 TERMINÉ 

Floating Sensorised Networked Robots for Water Monitoring (HydroNet)

Date du début: 1 déc. 2008, Date de fin: 31 janv. 2012,

Water is one of our most precious and valuable resources. It is important to determine how to fairly use, protect and preserve water. New strategies and new technologies are needed to assess the chemical and ecological status of water bodies and to improve the water quality and quantity. The relatively recent progress in micro-electronics and micro-fabrication technologies has allowed a miniaturiz ...
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 10

 TERMINÉ 

Physics and applications of nanocrystal - polymer nanophotonic devices (nanophotonic devices)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2011,

We propose the fabrication and optical study of new nanophotonic devices based on composite, highly transparent polymer matrices that incorporate near infrared, light emitting semiconductor nanocrystal quantum dots, on different sub-micron patterned surfaces. The devices will combine the atomic-like optical functionality of the nanocrystal quantum dots and the fabrication flexibility of the polyme ...
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 1

 TERMINÉ 

Gamma Ray Bursts and Their Afterglows (GRBandAFTERGLOW)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2011,

More than thirty years have passed since the detection of Gamma-Ray Bursts (GRBs) was first reported and enormous observational and theoretical efforts have been devoted to understanding this enigmatic phenomenon. Today, the GRB enigma, once one of the greatest mysteries in astrophysics, is partially solved: GRBs are the death throes of massive stars and the birth cries of black holes. Yet these o ...
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 1

 TERMINÉ 

Mechanisms of Poly-Ubiquitin Chain Assembly by Ubc7, a Ubiquitin Conjugating Enzyme of the Protein Quality Control System (Ubiquitin Chains)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2011,

Cell function and viability are dependent upon proper protein folding. To avoid abnormal and toxic deposition of proteins, the cells recruit the ubiquitin-proteasome system, by which ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s) work together to assemble poly-ubiquitin chains on misfolded or misassembled proteins, to be marked for degradation by the 26S proteasome. With the matu ...
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 1

 TERMINÉ 

Neural and behavioral correlates of ‘seeing’ without visual input using auditory-to-visual sensory substitution in blind and sighted: a combined fMRI-TMS study (Seeing with sounds)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2011,

In sensory substitution devices (SSDs), visual information captured by an artificial receptor is delivered to the brain using non-visual information via a human-machine interface. SSDs have the potential to play a major role in the adaptation to blindness. The first aim of this proposal will be to develop better training and behavioral paradigm to improve the use of SSDs for object recognition and ...
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 1

 TERMINÉ 

The role of a nuclear expression site in the regulation of virulence genes in malaria parasites (Malgenexpression)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2011,

The deadliest form of human malaria is caused by the protozoan parasite, Plasmodium falciparum, which annually infects millions worldwide. The virulence of P. falciparum is attributed to its ability to evade the human immune system, by modifying the host red blood cell surface to adhere to the vascular endothelium and to undergo antigenic variation. The main cell surface ligands responsible for bo ...
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 1

 TERMINÉ 

Electronic Chemical Cell (ECCell)

Date du début: 1 sept. 2008, Date de fin: 31 déc. 2011,

ECCellThe aim of the project is to establish a novel basis for future embedded information technology by constructing the first electronically programmable chemical cell. Thisis naturally a high-risk, embryonic research project, but aimed at a breakthrough which will lay the foundation for immersed micro- and nanoscale molecular information processing with a paradigm shift to digitally programmabl ...
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 5

 TERMINÉ 

Live imaging of nuclear dynamics in embryonic stem cell differentiation (LiveNucESC)

Date du début: 1 déc. 2007, Date de fin: 30 nov. 2011,

Owing to their unique ability to self-renew indefinitely, as well as their capacity to differentiate into multiple cell types of all three germ layers, embryonic stem (ES) cells hold great promise both as therapeutic agents in the clinic and as research tools in the lab. One of the main challenges in the field is understanding how stem cells achieve their remarkable potential. Recent efforts by us ...
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 1

 TERMINÉ 

Generation of mouse models for the study of cellular senescence in aging and cancer (Modeling Senescence)

Date du début: 1 déc. 2007, Date de fin: 30 nov. 2011,

Cellular senescence is a central biological mechanism for cancer prevention in mammals. Cells enter senescence when tumor-inducing genes are aberrantly activated, and in response undergo an arrest in proliferation accompanied by dramatic changes in metabolism and morphology, thus preventing their further development into tumors. Various types of physiologic stresses can also induce senescence, and ...
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 1

 TERMINÉ 

NanoTools for Ultra Fast DNA Sequencing (nanoDNAsequencing)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2011,

The demand for a next-generation of technologies for DNA sequencing that will provide fast and affordable DNA decoding is pressing. Present bio-chemical schemes are time consuming and expensive, thus cheap and fast alternatives for DNA “reading” are of great need. This is now internationally recognized. For example, the US NIH recently awarded 40M$ in grants overpiloting projects to spur developme ...
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 7

 TERMINÉ 

Molecular Logic Circuits (MOLOC)

Date du début: 1 févr. 2008, Date de fin: 31 juil. 2011,

MOLOC – Molecular Logic Circuits seeks to design and provide demonstration of principle, feasibility and significant advantages of logic circuits where the basic element is a single molecule (or assemblies of atoms or molecules) acting in itself as a logic circuit. The functionalities provided by this new post-Boolean approach differ in essential ways from using a molecule as a switch. The approac ...
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 6

 TERMINÉ 

Impact of International Criminal Procedures on Domestic Criminal Procedures in Mass Atrocity Cases (DOMAC)

Date du début: 1 févr. 2008, Date de fin: 30 avr. 2011,

"Although considerable attention has been given to the establishment and operation of international criminal courts and other international or internationalized mechanisms for determining individual and state responsibility in mass atrocity situations, their capacity remains limited and national courts continue to carry most of the burden of prosecuting the vast majority of perpetrators. However, ...
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 5

 TERMINÉ 

OneLab2 : An Open Federated Laboratory Supporting Network Research for the Future Internet (OneLab2)

Date du début: 1 sept. 2008, Date de fin: 31 janv. 2011,

Experimentally driven research is key to success in today's Internet. Many test beds support research and development, and product prototyping in communication networks. However, they tend to specialise in particular access technologies or services, or explore near term product offerings, often with limited availability and openness. An open and sustainable large-scale shared experimental facility ...
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 30

 TERMINÉ 

Just and durable peace by piece (JAD-PbP)

Date du début: 1 févr. 2008, Date de fin: 31 janv. 2011,

Peace is elusive and the quest for peace is perpetual. In Iraq, Afghanistan and the Middle East, peace and war exist in parallel and contemporary peace support operations simultaneously involve combat operations and building peace. Hence, the goal of establishing just and durable peace is a fundamental challenge to contemporary peacemakers and academics alike. In order to shed new theoretical and ...
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 7

 TERMINÉ 

On-chip simultaneous intracellular recording and stimulation of electrical and biochemical activities from hundreds of neurons (BRAIN STORM)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2010,

In the BRAINSTORM project, we aim to develop an integrated system enabling on-chip intracellular recordings from a relatively large cultured neuronal network combined with chemical sensing and intracellular delivery of biologically active molecules. To achieve tight coupling with the cell membrane and enable efficient recordings, micronail-type probes will be integrated with a CMOS readout circuit ...
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 4

 TERMINÉ 

Longitudinal Enhancement and Access imProvement of the SHARE infrastructure (SHARE_LEAP)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2010,

Population ageing is among the most pressing challenges of the 21st century in Europe. Addressing this challenge scientifically demands an infrastructure of micro data of the changing health, economic and social living conditions of individuals as they go through the ageing process. SHARE, the Survey of Health, Ageing and Retirement in Europe, is an infrastructure of multidisciplinary, longitudina ...
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 19

 TERMINÉ 

ROBot and SENSors INtegration as Guidance FOR Enhanced Computer Assisted Surgery and Therapy (ROBOCAST)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2010,

The ROBOCAST project aims to develop ICT scientific methods and technologies which focus on robot assisted keyhole neurosurgery. A modular system, allowing a reduction of the footprint, will be developed with two robots and one active bio-mimetic probe, able to cooperate among themselves in a biomimetic sensory-motor integrated framework. A gross positioning 3-axes robot will support a miniature p ...
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 11