5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Multimodal Imaging of rare Synucleinopathies (MultISyn)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
Despite remarkable progress in the understanding of the molecular pathogenesis of neurodegenerative diseases (NDD), no causative or disease-modifying treatment is currently available. Aggregation of misfolded proteins are thought to play a crucial role in the pathogenesis, but attempts to exploit this knowledge for novel treatments have not been successful. Also, pathogenetically relevant biomarke ...
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9
Participants partenaires
TERMINÉ
Cell and gene therapy based approaches for treatment of Parkinson's disease: from models to clinics (TREATPD)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2014,
Parkinson s disease is one of the common causes of disability in the aging population, representing a major health problem for the affected individuals and a socioeconomic burden to the society. In the present proposal, the applicant puts forward an ambitious but feasible program to tackle a number of significant issues that remain unsolved in the field. He combines his strong track record in anim ...
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1
Participant partenaire
TERMINÉ
Academic-Industrial Training Network on Alpha-Synuclein-related Brain Diseases (NEURASYNC)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,
"Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. It is characterized pathologically by the accumulation of aggregated conformations of the presynaptic protein alpha-synuclein (ASYN) in cytoplasmic inclusions termed Lewy Bodies (LBs). Furthermore, aberrant aggregated species of ASYN accumulate in various disease states, such as Multiple System Atrophy, Diffuse LB Dise ...
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11
Participants partenaires
TERMINÉ
European Project on Mendelian Forms of Parkinson’s Disease (MEFOPA)
Date du début: 1 avr. 2010, Date de fin: 30 sept. 2013,
"The Collaborative Project on Mendelian Forms of Parkinson’s Disease (MEFOPA) will bring together the major groups in Europe with a track-record in basic and clinical research on rare Mendelian forms of Parkinson’s disease (PD) in order to identify and validate relevant disease-related molecular pathways, drug-targets and biomarkers for disease susceptibility and progression.. Over the last years ...
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27
Participants partenaires
TERMINÉ
Effects of posttranslational modifications of alpha-synuclein on dopaminergic neurodegeneration in a novel viral vector mediated in vivo model of Parkinson’s disease (modifyPD)
Date du début: 1 nov. 2010, Date de fin: 31 oct. 2012,
One of the major pathological hallmarks of Parkinson´s disease (PD) is the progressive loss of specific dopaminergic projection neurons, especially those located in the substantia nigra pars compacta. The neurodegeneration is accompanied by the presence of cytoplasmic inclusions called Lewy bodies, which invariably contain the α-synuclein (α-syn) protein as a major component. Aggregation of α-syn ...
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