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 TERMINÉ 

The interpretive function and syntactic category of noun classes (NOUN CLASSES)

Date du début: 1 mars 2014, Date de fin: 1 mars 2019,

A central goal of modern linguistic theory is to find out what properties are shared, and what properties are different across human languages. Following Chomsky (1981, 1988), the shared properties are attributable to Universal Grammar, i.e. our innate capacity to learn a human language, and following Borer (1984) the variable ones are due to cross-linguistic differences in inflectional elements ...
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 1

 TERMINÉ 

Developing Multispecific Biological Agents that Target Tumor Neovasculature for Cancer Imaging and Therapy (BisProt)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

The dysregulation of signaling pathways that mediate cell proliferation, survival and migration is an underlying cause of many cancers. In particular, dysregulation and over-expression of avb3 integrin, membrane-type-1 matrix metalloproteinase (MT1-MMP; also known as matrix metalloproteinase-14, MMP14) and vascular endothelial growth factor receptor-2 (VEGFR2) correlate with poor prognosis in many ...
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 1

 TERMINÉ 

Targets and biomarkers for antiepileptogenesis (EPITARGET)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a comb ...
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 20

 TERMINÉ 

Collaborative REsearch on ACute Traumatic brain Injury in intensiVe care medicine in Europe (CREACTIVE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

"Traumatic brain injury (TBI) is among the leading causes of death and disability and the main cause of death among the under-45s. Most patients with moderate to severe TBI are admitted to intensive care units (ICUs)The “PROSAFE” ICU network was recently established in 6 European countries through EU funding (PHEA 2007331), and has continued to collect high-quality data beyond the grant duration. ...
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 11

 TERMINÉ 

Transport Properties of Emergent Edge States in Interacting Topological Superconductors (IntTopSup)

Date du début: 1 sept. 2014, Date de fin: 31 août 2018,

Topological superconductors are known to harbor Majorana bound states at their boundaries and inside vortex cores. Their non local properties and non-Abelian exchange statistics make Majorana bound states potential candidates in fault tolerant quantum computational schemes. Recently it has been pointed out that interacting topological superconductors support even more exotic non-Abelian excitation ...
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 1

 TERMINÉ 

Investigating Directed Information (DirectedInfo)

Date du début: 1 août 2013, Date de fin: 31 juil. 2018,

This research investigates a new measure that arises in information theorycalled directed information. Recent advances, including our preliminary results, shows thatdirected information arises in communication as the maximum rate that can be transmitted reliablyin channels with feedback. The directed information is multi-letter expression and therefore veryhard to optimize or compute.Our plan is f ...
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 1

 TERMINÉ 

Assessing Temporally and Spatially Resolved PM2.5 and Air Temperature Exposures For Epidemiological Studies Using Satellite Based Methods (STRPM)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,

"Exposure to PM2.5 has been associated with increased risk of myocardial infarction, reduced birth weights, cardiovascular and respiratory disease. Climate changes will lead to warmer air temperatures (Ta) and more extreme weather events,which are associated with increased morbidity and mortality in sensitive populations. Current epidemiological studies on the health effects of PM2.5 and Ta have m ...
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 1

 TERMINÉ 

New Directions in Meta-Kernelization (MetaKer)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,

Preprocessing for the purpose of simplifying problem instances is a universal algorithmic technique applied in almost every software implementation. Understanding and assessing preprocessing techniques is therefore of crucial practical importance in computer science. Kernelization is a notion developed in the area of parameterized complexity that provides a the only known reasonable mathematical m ...
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 1

 TERMINÉ 

The role of gene regulatory elements in forebrain development and epilepsy (FB-regulome)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,

The human forebrain plays critical roles in cognition, motor function, and emotion. Impaired forebrain development and function are associated with neurodevelopmental disorders, including epilepsy.Early onset of epilepsy is a spectrum of disorders with strong genetic components that could be difficult to precisely diagnose and provide effective treatments. A major and underexplored cause of comple ...
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 1

 TERMINÉ 

School Food Environments (School Food Environ.)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,

Obesity rates have nearly tripled since the 1980’s in the United States and in many European countries, and this rise has been particularly alarming with regards to children. To combat childhood obesity, policy makers have increasingly been examining school food environments. School food environments are defined as policies enacted by a school affecting students’ dietary intake during the school d ...
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 1

 TERMINÉ 

Misfolded SOD1 Toxicity in Amyotrophic Lateral Sclerosis (Misfolded SOD1-ALS)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease characterized by the loss of upper and lower motor neurons. The reason for the degeneration of motor neurons in ALS is still unknown. Mitochondria have been implicated as a possible target for toxicity by several studies reporting a range of dysfunctions and the toxic binding of misfolded SOD1 to mitochondrial targ ...
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 1

 TERMINÉ 

Role of transcription factor Hlf in hematopoietic stem cells (Hlf in HSC)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

Adult stem cells necessitate a transcriptional state that sustains multipotency and self-renewal for lifetime. Hematopoietic Stem Cells (HSC) are the source of all blood cells and lead both biological study and clinical utilization of stem cells – by saving thousands every year with bone-marrow transplant. However, understanding how HSC sustain stem-cell state is still limited. During my PostDoc I ...
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 1

 TERMINÉ 

Exploring attosecond science at the angstrom and nanoscale (AttoIm)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

High harmonic generation (HHG), being the backbone of attosecond science, possesses a unique combination of properties, not only in the temporal but also in the spectral domain, that could be very attractive in studies of matter at the angstrom and nano-scales.Remarkable spatial coherence of the HHG hold a potential of their use as a laser-like source.However recently discovered strong dependence ...
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 1

 TERMINÉ 

The Role of SETD6 Methyltransferase in the Modulation of Oncogenic Processes (K-Methylation)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

My overarching goal is to investigate the importance of protein post-translational modification (PTM) networks in cancer. The signaling system defined by the PTM lysine methylation has recently emerged as a potential key regulator of cancer pathways. However, the mechanisms by which protein lysine methyltransferase (PKMT) enzymes contribute to cancer are poorly understood. I believe that character ...
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 1

 TERMINÉ 

Size Matters in Numerical Cognition (SMiNC)

Date du début: 1 sept. 2012, Date de fin: 31 août 2017,

Numerical cognition is essential to many aspects of life and arithmetic abilities predict academic achievements better than reading. Acquiring a solid sense of numbers and being able to mentally manipulate numbers are at the heart of this ability. In recent years research has been marked by looking for the underlying mental operations, an effort to unravel the neural tissue that supports these ope ...
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 1

 TERMINÉ 

Homotopy theory of quasi-coherent sheaves on stacks (HOMOQCSSTACKS)

Date du début: 15 janv. 2012, Date de fin: 5 juin 2017,

In the last decade there has been a growing interconnection between algebraic geometry and homotopy theory. This project is part of that exciting development. The primary researcher has developed a homotopy theoretic approach to the theory of stacks. As part of this project the PI will apply this approach to the study of quasi-coherent sheaves on stacks and questions of representability by algebra ...
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 1

 TERMINÉ 

Integration of Immigrants in Western European Countries: A Comparative Sociology Perspective (Im-It)

Date du début: 1 oct. 2012, Date de fin: 30 avr. 2017,

The proposed project aims to undertake a systematic investigation of the incorporation of immigrants into the labor market of Western European countries within a comparative sociology framework. The study will be conducted with a cross-national comparative perspective, while simultaneously examining the impact of ethnic origin and generation on various labor market outcomes for immigrants. Thus, t ...
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 2

 TERMINÉ 

“Digital Detours” – How marginalized and underserved communities can overcome the digital divide (Digital Detours)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

"This research project aims to:1. Better our understanding of the causes for and the nature of the digital divide in Israel;2. Provide insight into how the information needs of marginalized and excluded communities can be met;3. Propose policy interventions that will address providing the information essentials of the needy.The project involves a mapping of underserved communities in Israel, ident ...
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 1

 TERMINÉ 

Embodied Audition for RobotS (EARS)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2016,

The success of future natural intuitive human-robot interaction (HRI) will critically depend on how responsive the robot will be to all forms of human expressions and how well it will be aware of its environment. With acoustic signals distinctively characterizing physical environments and speech being the most effective means of communication among humans, truly humanoid robots must be able to ful ...
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 6

 TERMINÉ 

High Energy QCD for Heavy Ions (QCDHI)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

"We have entered the fascinating era of the Large Hadron Collider (LHC).Both the searches for new physics in proton-proton collisions andthe investigations of the high-energy medium effects in heavy-ion (HI) collisions require a solid understanding of multiplegluonic interactions. With an increase in energy, gluon densities rise rapidly.When probed at very high energies, heavy nuclei and even ...
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 2

 TERMINÉ 

Demonstrating Managed Aquifer Recharge as a Solution to Water Scarcity and Drought (MARSOL)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2016,

Southern Europe and the Mediterranean region are facing the challenge of managing its water resources under conditions of increasing scarcity and concerns about water quality. Already, the availability of fresh water in sufficient quality and quantity is one of the major factors limiting socio economic development. Innovative water management strategies such as the storage of reclaimed water or ex ...
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 23

 TERMINÉ 

Infrastructure for Analysis and Experimentation on Ecosystems (ANAEE)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

ANAEE will provide Europe with a distributed and coordinated set of experimental, analytical and modelling platforms to analyse and predict in a precise manner the response of the main continental ecosystems to environmental and land use changes. ANAEE will consist of highly equipped in natura and in vitro experimental platforms associated with sophisticated analytical and modelling platforms coup ...
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 18

 TERMINÉ 

Novel Design of Nanostructures for Renewable Energy: Fundamental Questions and Advanced Applications (Nano@Energy)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

Photovoltaics and liquid fuels are poised as major contributors to the global energy market, promising cleaner, renewable sources of energy than fossil fuels. However, the technologies required to make this possibility a reality are limited by their high cost per kWh, and current share of photovoltaics and liquid fuels in the energy market is thus extremely small. One method of reducing the costs ...
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 1

 TERMINÉ 

Detection and manipulation of Majorana modes in topological superconductors (DMMMTS)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"In recent years there has been a fast growing interest in Majorana fermions in condensed matter systems. These elusive particles, first predicted in the 1930s, are still awaiting experimental verification. It was recently realized that certain interacting systems in condensed matter physics hold a great promise for realizing Majorana fermions as emergent degrees of freedom. The candidate systems ...
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 1

 TERMINÉ 

Complex Dynamics of Swarming Bacteria in Three Dimensions (3D Swarming)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

Motile bacteria are able to colonize surfaces using various types of motility. ‘Bacterial swarming’ is the most rapid method, involving an organized, hyperflagellated-based cell motion and collective secretion of bio-surfactants. During swarming, bacteria exploit hydrodynamic interactions; they move in whirls and jets similarly to flocks of birds and schools of fish. Hundreds of cells migrate on t ...
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 1

 TERMINÉ 

Effect of an External Electric Field on Grain Boundary Evolution in the Course of Nano-Ceramic Sintering (EEEF-GBE-CNS)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"Consolidation of oxide nanoparticles in the presence of an electric field has provided promising results for retaining the nanostructure in the bulk. Although the sintering of nanoparticles shares the same basic principles as those for the sintering of coarser particles, a number of issues and challenges are specific to nanosintering. From a thermodynamic point of view, solid state sintering can ...
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 1

 TERMINÉ 

The Role of Dimension in Metric Embedding (Dimension)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

We are currently witnessing the generation of massive amounts of data that require analysis, particularly in application areas such as computational biology, text mining, networking and web applications. Many of these computational tasks can be performed efficiently in low dimensional Euclidean space. In this research proposal, I will set out to investigate fundamental questions in the field of m ...
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 1

 TERMINÉ 

Global Plate Reconstructions During the Cretaceous Normal Superchron (GEOPLATE)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"Marine magnetic anomalies constitute the backbone of plate tectonic studies. Together with the known time scale of past polarity reversals of the geomagnetic field, these anomalies can be used to date the oceanic crust. However, periods of several tens of million years (Myr), when the polarity of the geomagnetic field remained stable (i.e., superchrons), lack prominent magnetic anomalies and ther ...
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 1

 TERMINÉ 

Operator-algebraic geometry in the unit ball (OAGUB)

Date du début: 1 sept. 2012, Date de fin: 31 août 2016,

"In this project, I plan to study the interaction between operator theory, function theory and algebraic geometry in some reproducing kernel Hilbert spaces (and their multiplier algebras), which live on subvarieties of the unit ball. The reproducing kernel Hilbert spaces (RKHSs) that I shall consider in this project are the quotients of Drury-Arveson space by a radical, homogeneous ideal.I plan to ...
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 2

 TERMINÉ 

Electron Spin Noise Scanning Tunneling Microscopy (ESNSTM)

Date du début: 1 juin 2012, Date de fin: 31 mai 2016,

"The final goal of this proposal is to develop an SPM technique which is capable of identifying the type of atom which is under the tip while tunneling. The idea is to exploit the recent success in detection the hyperfine coupling between electron and nuclear spins on the surface and to detect the hyperfine coupling between the electron spin on the tip and a nuclear spin on the surface.ESN-STM is ...
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 5

 TERMINÉ 

Quantum magnetic sensing of neurons using nitrogen-vacancy centers in diamond (NEURONQ)

Date du début: 1 juin 2014, Date de fin: 31 mai 2016,

Brain research and quantum technology are at the focus of 21st century science. Although theoretical and experimental studies have provided some insights regarding the mechanisms of how the brain acquires, represents and stores information, a comprehensive theory of the brain and the underlying neural information processing is still missing. Experimental techniques to study brain processes on diff ...
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 1

 TERMINÉ 

Development of an accessible platform for ex vivo site specific post-translational modifications of proteins (PROTLEGO)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,

The incorporation of unnatural amino acids (more than 50 to date) into proteins in vivo has resulted in the generation ofproteins with novel chemical, biological, and physical properties. However, some unnatural amino acids possess properties,such as an inability to cross the cell membrane or a level of toxicity dangerous to the organism, that restrict their incorporationinto proteins in vivo. In ...
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 1

 TERMINÉ 

Rational and Combinatorial Engineering of Antagonistic Angiopoietin Variants as Tools for Cancer Imaging and Therapy (Angiopoietins)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

The dysregulation of cell signaling pathways that mediate proliferation, survival, and migration is an underlying cause of many cancers. Dysregulation and over-expression of the Tie2 tyrosine kinase receptor, in particular, correlates to a poor prognosis for many human tumors, making Tie2 an attractive target for therapeutic intervention. Currently no FDA-approved therapeutics targeting the Tie2 ...
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 1

 TERMINÉ 

Hydrogen Cyanide and Thiocyanate Transformations in Anoxic Aquatic Systems (ThioCyAnOx)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

Hydrogen cyanide (HCN) is a toxic compound, whose sources in natural aquatic systems are mostly of anthropogenic origin. Although a variety of organisms, most notoriously vascular plants, produces HCN, its release from natural sources is not considered to be an important source of HCN contamination of aquatic environments. Recent results of my research showed that concentrations of HCN, which are ...
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 1

 TERMINÉ 

Towards Engineered Multicomponent Polysaccharide Hydrogels for Surrogate Extracellular Matrices (EMP-ECM)

Date du début: 1 mars 2012, Date de fin: 29 févr. 2016,

"Current effort in the engineering of synthetic extracellular matrixes has focused on installing molecular features (peptides, proteins and bio-interactive polymers) within insoluble scaffolds, either by self-assembly or through covalent modifications of polymer or biopolymer networks. Apart from their direct role in cell interaction, bioactive molecules or peptide sequences affect the hierarchica ...
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 1

 TERMINÉ 

Insight into the synergistic interactions between Aβ amyloid, α-synuclein and Tau (AbetaAlphasynTau)

Date du début: 1 mars 2012, Date de fin: 29 févr. 2016,

Protein aggregation is associated with numerous incurable diseases, including Aβ and tau proteins in Alzheimer’s disease (AD) and α-synuclein in Parkinson’s disease (PD). In vivo studies illustrate that these proteins appear in the brains of both AD and PD patients and that there are synergistic interactions between α-synuclein and tau, Aβ and tau, and α-synuclein and Aβ. Despite the accumulating ...
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 1

 TERMINÉ 

Identification of vernalization-related genes in Easter Lily bulbs for molecular markers production, vernalization control and improved flower production (Lily vernalization)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

"The flower bulb industry worldwide and specifically in Holland, and the lily sector in particular, represent an important part of the floriculture market. Lily and most bulb speciesrequire prolonged cooling to meet their obligatory vernalization (acquisition of the ability to flower following exposure to prolonged cold) requirement, which is expensive and energy-costly and hinders the production ...
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 2

 TERMINÉ 

Non-Equilibrium Processes in Galaxy Clusters (NEPAL)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

"I propose to study the dynamical and nonthermal processes in the intracluster medium (ICM) by combining a phenomenological analysis of observational data, a theoretical study, and dedicated numerical simulations.The proposed research is designed to address the central open questions in the theory of clusters, resolve the present tension between observations and simulations, distinguish between di ...
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 1

 TERMINÉ 

Systems Chemistry from Bottom Up: Switching, Gating and Oscillations in Non Enzymatic Peptide Networks (BOTTOM-UP_SYSCHEM)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2015,

The study of synthetic molecular networks is of fundamental importance for understanding the organizational principles of biological systems and may well be the key to unraveling the origins of life. In addition, such systems may be useful for parallel synthesis of molecules, implementation of catalysis via multi-step pathways, and as media for various applications in nano-medicine and nano-electr ...
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 1

 TERMINÉ 

Stochastic Modeling of Spatially Extended Ecosystems and Ecological and Climate Data Analysis (SMSEE)

Date du début: 1 sept. 2011, Date de fin: 31 août 2015,

The coupling between ecosystems and the climate implies that quantifying their dynamics is crucial for our attempts to prevent undesired changes in our environment. The main goal of this project is to use non-linear, stochastic modeling in the context of climate and ecosystems dynamics. This proposal combines methods from statistical physics, non-linear dynamics, game theory and random dynamical s ...
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 1