6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,
In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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45
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TERMINÉ
Systems biology of liver cancer: an integrative genomic-epigenomic approach (MODHEP)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2016,
"Cancer is a complex disease involving multiple genetic and epigenetic events occurring, and influencing each other, over a long period of time. Understanding cancer, and ultimately developing effective targeted therapies, will therefore require that mutations and epigenetic alterations be systematically investigated during the multiple stages of disease development, from identifiable pre-neoplast ...
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18
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TERMINÉ
Studying Physiology and Pathology of Imprinted Genes to understand the role of Epigenetic Mutations in Human Disease (INGENIUM)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,
"The aim of this ITN is to promote research and training in the field of epigenetics associated with human disease. Expression of imprinted genes is mono-allelic and gamete of origin-dependent. This is due to different epigenetic modifications present on the maternal and paternal chromosomes. Failure in normal establishment, maintenance or erasure of these marks results in gene dosage dysregulatio ...
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10
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TERMINÉ
Epigenetics towards systems biology (EPIGENESYS)
Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,
The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
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28
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TERMINÉ
Analysis of the roles of the TRPV2 calcium channel in inflammation (TRPV2PI3KMacrophage)
Date du début: 2 mars 2009, Date de fin: 1 sept. 2011,
Macrophages are key players in the front line of our immune system, responsible primarily for the recognition and destruction of bacterial and fungal pathogens. However, they are also involved in various inflammatory pathologies. Membrane receptors of chemokines control many aspects of macrophages functions by stimulating various 2nd messenger systems, important amongst these are PI3Ks and Ca2+. H ...
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1
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TERMINÉ
The role of Kcnk9 imprinting in development and disease (Kcnk9 imprinting)
Date du début: 1 juil. 2008, Date de fin: 30 juin 2010,
Genomic imprinting is the epigenetic marking of a subset of genes which results in monoallelic or predominant expression of one of the two parental alleles according to their parental origin. In my previous work, I discovered the imprinted expression of the Kcnk9 gene in mice and humans. Kcnk9 is a member of the two-pore (2P)-domain K+ channel family and encodes for the potassium channel protein T ...
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