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 TERMINÉ 
Although vaccination is the cornerstone of prophylaxis, current vaccines provide only moderate protection. Most employ inactivated or protein-based, including multimeric antigen, vaccines requiring annual updating. Their limited antigen loads provide limited capacity for inducing robust immune defences, without assurance that both humoral and cell mediated (CMI) responses, as well as durable immun ...
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 11

 TERMINÉ 
The capacity of zoonotic RNA viruses to emerge as major agents of human disease can appear limitless. Current intervention strategies have demonstrated limited success. Rapid, innovative and effective solutions are needed to reduce the apparently accelerating process of zoonotic disease emergence. We will study the following zoonotic viruses with epidemic potential in Europe: influenza virus, hepa ...
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 20

 TERMINÉ 
Porcine reproductive and respiratory syndrome virus (PRRSV) is the major cause of reproductive and respiratory problems in pigs worldwide. Controlling this disease is a top priority in pig producing countries. Due to mutations at a high frequency, new variants of the virus appear that are no longer effectively controlled by the commercial vaccines. In addition, highly virulent variants emerge, lea ...
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 16

 TERMINÉ 
"Foot-and-mouth disease (FMD) is one of the world’s most infectious diseases of livestock and continues to pose a significant threat to endemic and free regions alike. The impact of FMD on society and international trade is high, thereby demanding stringent prevention, surveillance and control plans taken up in crisis preparedness plans. On the other hand, there is a global increased demand for an ...
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 15

 TERMINÉ 
Although classical swine fever (CSF) has been eradicated in wide areas within the EU the disease is endemic in some new member states particularly in back yard pigs. In order to improve the eradication strategies the project aims are a) the final development and testing of a live marker vaccine candidate for the prevention and improved control of CSF, both orally and intramuscularly applicable; b) ...
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 18