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Personalized bioinformatics for global cancer susceptibility identification and clinical management (PanCanRisk)
Date du début: 1 juil. 2015, Date de fin: 30 juin 2018,
Cancer sequencing studies have extensively investigated the landscape of somatic mutations that drive tumor development, however the importance of germline variation for cancer susceptibility has been neglected. We hypothesize that for cancer types affecting a large proportion of the population, a shared set of genes with variants of different levels of penetrance leads to the clinical phenotype. ...
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