8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Paediatric Clinical Research Infrastructure Network (PedCRIN)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Children’s health is a major societal challenge for Europe and the world, requiring development of paediatric medicines and treatments strategies based on evidence derived from clinical trials demonstrating efficacy and safety in infants and children, rather than on uncritical extrapolation from adult data (over 50 % of the medicines used for children had not been tested in this specific age group ...
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16
Participants partenaires
TERMINÉ
Treatment of late onset bacterial sepsis caused by vancomycin susceptible bacteria in neonates and infants aged under three months (NEOVANC)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
Vancomycin is the critically important antibiotic to treat neonatal Late Onset Sepsis (LOS) due to Gram positive bacteria in neonates, including Coagulase Negative Staphylococci (CoNS) and Staphylococcus aureus. These organisms also create biofilms which are extremely resistant to antibiotics. The increased incidence of LOS due to bacteria such as CoNS and MRSA in NICUs has led to a marked increas ...
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14
Participants partenaires
TERMINÉ
SMART: Small Medicines Advanced Research Training (SMART)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,
SMART Project is aimed to raise IPCZD staff’s research profile and increase capacity in providing innovative paediatric research methods such as PK-PD data Modelling&Simulation (M&S) data extrapolation, and suitable dosage forms identification. This represents both a specific IPCZD’s need (PCZD has a solid experience in providing and accumulating paediatric PK-PD data but is unable to use this dat ...
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4
Participants partenaires
TERMINÉ
GAbapentin in Paediatric Pain (GAPP)
Date du début: 1 juil. 2013, Date de fin: 30 juin 2017,
Chronic pain is estimated to affect 15-20% of children with varying disabilities. Due to the paucity of clinical information and appropriate medicinal products, in clinical practice paediatric patients are often under-treated causing profound impact on their QoL.To date, opioids, non-steroid anti-inflammatory drugs (NSAIDs), antidepressants and anticonvulsants are used to treat pain, but only few ...
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16
Participants partenaires
TERMINÉ
Global Research in Paediatrics (GRiP)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2017,
Paediatric drugs (PD) lack appropriate testing. Most drugs have inadequate information about dosing regimen, dose adjustment and how to administer them. These are longstanding problems that unquestionably require concerted efforts at the international level. Both the US and the EU have introduced paediatric legislation that facilitates participation of children in research and pharmaceutical innov ...
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24
Participants partenaires
TERMINÉ
DEferiprone Evaluation in Paediatrics (DEEP)
Date du début: 1 janv. 2011, Date de fin: 31 août 2016,
"β-thalassaemia major is one of the most severe forms of chronic congenital anaemia. The recommended treatment consists in regular blood transfusions combined with chelating therapy to remove harmful iron accumulation in the body. The use of deferoxamine, the first chelating agent only available for subcutaneous administration is limited due to toxicity and the lack of compliance, despite its sat ...
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18
Participants partenaires
TERMINÉ
European multicenter network to evaluate pharmacokinetics, safety and efficacy of Meropenem in neonatal sepsis and meningitis (NEOMERO)
Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,
Previous studies have demonstrated the high frequency of bacterial sepsis in neonates and infants admitted to neonatal intensive care unit (NICU), often associated with serious complications or death. Many pathogens capable of causing nosocomial bacterial sepsis in neonates and young infants have developed resistance to the antibiotics considered of choice for treatment. Meropenem is an antibiotic ...
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12
Participants partenaires
TERMINÉ
Relating Expectations and needs to Participation and Empowerment of children in Clinical Trials (RESPECT)
Date du début: 1 juin 2008, Date de fin: 31 août 2011,
"There are two objectives for this project, firstly to clarify the expectations and needs of children and their families who have participated or who might participate in clinical trials for new drugs in Europe. Secondly, to identify methods by which the expectations and needs can be translated into empowering and motivating participants in future clinical trails research. This will be achieved in ...
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