8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
A European Platform for Translational Cancer Research (EUROCANPLATFORM)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,
Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer research and stressed the need to improve collaboration between basic/preclinical and comprehensive cancer centres (CCCs), in ...
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29
Participants partenaires
TERMINÉ
The DNA damage response and breast cancer (DDRESPONSE)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,
We will exploit the DNA damage response (DDR) to assess and predict individual susceptibility and response focussed on breast cancer and breast cancer therapies. The 1st targeted therapy based on the DDR is inhibition of PARP by olaparib, which induces synthetic lethality in cancer cells with a specific DDR defect. Our members discovered olaparib, which is currently in Phase II trials. Its use in ...
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6
Participants partenaires
TERMINÉ
Breast Cancer Somatic Genetics Study (BASIS)
Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,
"All cancers arise due to somatically acquired mutations in their genomes which alter the function of key cancer genes. Understanding these critical mutational events underlying cancer development is paramount for advancing prevention, early detection, monitoring and treatment of the disease. Breast cancer is the most common class of cancer diagnosed in women worldwide with more than one million c ...
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16
Participants partenaires
TERMINÉ
pARylation-mediated regulation of cancer pathways (pARylome)
Date du début: 1 mars 2011, Date de fin: 8 août 2013,
Poly(ADP)ribosylation (pARylation) is an important post-translational modification of proteins that affects diverse biological processes such as DNA damage repair, apoptosis and transcription. The conjugation of Poly(ADP)-ribose (pADPr) to target proteins is mediated by members of the Poly(ADP)-ribose polymerase (ARTD/PARP) protein family. ADPr can be attached either as a single moiety or as chain ...
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1
Participant partenaire
TERMINÉ
Molecular mechanisms of melanoma invasion (Melanoma Invasion)
Date du début: 1 juin 2011, Date de fin: 14 juin 2013,
Malignant melanoma is highly invasive and metastatic resulting in a major clinical problem in management of the disease. The aim of this project is to gain a better understanding of mechanisms of cell migration to identify novel therapeutic targets to block invasion. Disruption of cell signalling pathways that dynamically regulate the cytoskeleton underlie the altered migratory potential of tumour ...
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1
Participant partenaire
TERMINÉ
The influence of Her2 status on mammary stem/progenitor cells (HER2 MAMMARYSTEMCELL)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2011,
"c-ERBB2/HER2 is a gene that is found overexpressed in ~25% of mammary tumours, and defines the molecular signature of one of the breast cancer subtypes: the HER2-positive tumour subtype. However, the role of the c-ErbB2 tyrosine kinase and the stem cell of origin of HER2-positive breast cancers are poorly understood. Our project aims to study the relationship between c-ErbB2 function and normal a ...
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1
Participant partenaire
TERMINÉ
Synthetic lethality approaches to BRCA-associated cancer (SYNTHLE BRCA)
Date du début: 1 sept. 2008, Date de fin: 31 août 2010,
"Mutations in BRCA1 and BRCA2 genes confer high lifetime risks of developing breast and other cancers. Moreover, several studies suggest that tumours arising in mutation carriers have generally lost the wild-type allele and do not express functional BRCA1 or BRCA2 proteins. Both BRCA proteins are important for repair of double strand DNA breaks by homologous recombination. The subject of this proj ...
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1
Participant partenaire
TERMINÉ
Characterization of myoepithelial differentiation in basal-like breast cancer cells (Basal Breast Cancer)
Date du début: 1 juin 2008, Date de fin: 31 mai 2010,
Translational research in cancer is one of the thematic priorities within FP7 Health Investigation Programme. Breast cancer is the most frequent tumour type in European women. 20-25% of breast carcinomas express myoepithelial markers, thus showing the basal-like phenotype. Basal-like tumours are typically high-grade, aggressive cancers with poor prognosis. Since basal-like phenotype closely resemb ...
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