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11 projets européens trouvés

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 TERMINÉ 

Protein Translocation Through Bacterial Syringes (BACTERIAL SYRINGES)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

"The main objective of this application is to study the molecular basis of cellular infection by bacterial ABC-type toxins (Tc). Tc complexes are important virulence factors of a range of bacteria, including Photorhabdus luminescens and Yersinia pseudotuberculosis that infect insects and humans. Belonging to the class of pore-forming toxins, tripartite Tc complexes perforate the host membrane by f ...
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 1

 TERMINÉ 

Systems analysis of pancreatic tumor cell phenotype dependence on the spatial regulation of oncogenic Ras signaling (SPATONC)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

"Over the last several years me and my team have uncovered the reaction cycles that dynamically maintain the spatial organization of the Ras proto-oncogene products on cellular membranes. The quantitative microscopic imaging approaches in close iteration with computational systems dynamic analysis that we developed in the course of these studies were key to understand these reaction systems which ...
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 1

 TERMINÉ 

PRIMES: Protein interaction machines in oncogenic EGF receptor signalling (PRIMES)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,

"PRIMES focuses on the role of protein interactions to assemble dynamic molecular machines that receive and process information to coordinate cellular responses. PRIMES investigates the following: (i) How do protein interactions contribute to the generation of biological specificity in signalling? (ii) How do pathogenetic perturbations affect protein interaction networks? (iii) How can we exploit ...
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 14

 TERMINÉ 

The Role of Arl Proteins in Retinal and other Ciliary Diseases (ARCID)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

"Arl (Arf-like) proteins, GTP-binding proteins of the Ras superfamily, are molecular switches that cycle between a GDP-bound inactive and GTP-bound active state. There are 16 members of the Arl subfamily in the human genome whose basic mechanistic function is unknown. The interactome of Arl2/3 includes proteins involved in retinopathies and other ciliary diseases such as Leber¿s Congenital Amauros ...
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 1

 TERMINÉ 

Systems Chemical Biology - Chemical Biological Perturbation and Dissection of Dynamic Biological Systems (SYSCHEMBIOL)

Date du début: 1 mars 2011, Date de fin: 29 févr. 2016,

In Systems Chemical Biology research small drug-like molecules are employed to analyze the construction, wiring and spatiotemporal regulation of protein networks in dynamic biological systems. They act fast, reversibly, conditional, do not alter network architecture and need to be biologically relevant, a property particularly given for the scaffolds of natural product classes chosen in evolution ...
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 1

 TERMINÉ 

Small molecule stabilizers of 14-3-3 Protein-Protein Interactions as novel drugs in cancer and neurodegenerative diseases (14-3-3Stabs)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

The objective of the application is the development and characterization of small molecule stabilizers of protein-protein interactions (“Molecular Glues”) as a novel class of biological tool compounds and potential therapeutic drugs for the treatment of cancer as well as Alzheimer’s and Parkinson’s Disease, respectively. As biological targets we work on 14-3-3 proteins, an important class of adapt ...
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 5

 TERMINÉ 

Molecular organization of the kinetochore-microtubule interface (KT-MT interface)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2015,

This application is concerned with the reconstitution of the outer kinetochore, and its analysis by biophysical techniques and electron microscopy. The kinetochore is a large multi-subunit and multi-copy protein complex that bridges mitotic chromosomes with spindle microtubules. The kinetochore-microtubule interface is crucially important for faithful division of replicated DNA during mitosis and ...
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 1

 TERMINÉ 

Molecular bases of kinetochore-microtubule attachment and their implications for cell cycle control (KINCON)

Date du début: 1 mars 2009, Date de fin: 30 sept. 2014,

Equal partition of the genetic material to the daughter cells in mitosis requires the accurate anchorage of the mother cell s chromosomes to spindle microtubules. This process takes place at kinetochores, complex scaffolds containing ~100 different proteins. Conceptually, kinetochores can be viewed as performing four distinct but highly integrated functions: 1) they bind centromeric chromatin at a ...
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 3

 TERMINÉ 

Structural studies of actin nucleator complexes (actin-nucleators)

Date du début: 14 oct. 2010, Date de fin: 13 oct. 2013,

Actin is one of the most conserved globular proteins among diverse species. It plays a major role in many important cellular processes that range from muscle contraction, cell motility, cell division and cytokinesis to vesicle/organelle-movement, cell signaling, maintenance of cell junctions and shape. Actin filaments are major determinants of cell morphology and are sites for focal adhesion in mu ...
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 1

 TERMINÉ 

Inhibiting Nef: a novel drug target for HIV-host interactions (iNEF)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2011,

Although HIV-1 Nef was originally named "negative factor," it has been shown to be critical for efficient persistance of HIV-1 infected humans thus playing a major role in the progression to AIDS. Remarkably; until now Nef has not been evaluated as an antiretroviral drug target. It is well established that Nef promotes HIV-1 replication and facilitates viral immune evasion by interacting with vari ...
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 9

 TERMINÉ 

Antibacterial lead discovery with D/L-peptide libraries (D/L-Peptide Library)

Date du début: 1 sept. 2009, Date de fin: 30 juin 2010,

Nowadays, a multitude of examples for targeting enzymes with small molecules is known, whereas the direkt access to macromolecular interaction, such as DNA/protein, RNA/protein and protein/protein within the cell still waits to be solved by generic methods. We intend to create a toolbox for targeting these interactions with D-/L-peptides, a new class of biostable oligomer ligands. Initially we wil ...
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 1