3 projets européens trouvés
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TERMINÉ
Function and computation in three-layer cortex (CORTEX SIMPLEX)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,
"Understanding brain function is one of the outstanding challenges of modern biology. Many studies focus on mammalian neocortex, a modular and versatile structure that operates equally well with different sensory inputs and for perception, planning as well as action. Neocortex, however, is remarkably complex. It contains many cell types, six layers, networks with local and long-range connections, ...
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TERMINÉ
Dynamics of local transcriptomes and proteomes in neurons (Neuronal dynamics)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,
The ability of the nervous system to respond adaptively relies on modifications to existing proteins as well as changes in gene transcription and protein translation. An individual neuron in the brain possesses approximately 10.000 synapses, many of which are hundreds of microns away from the cell body. As many of the changes to environmental stimuli occur at synapses, the question arises as to ho ...
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TERMINÉ
Local Processing of Dendritically Synthesized Membrane Proteins (DENDRITIC PROCESSING)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2015,
"The local synthesis and degradation of proteins represent a particularly efficient means to adaptively modify the composition of targeted dendritic branches and associated synapses.Recent data from our laboratory show that numerous mRNA encoding neurotransmitter receptors and voltage-gated channels are enriched in distal dendrites, indicating that local translation sustains local membrane protein ...
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