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13 projets européens trouvés

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 TERMINÉ 

Toxic protein aggregation in neurodegeneration (ToPAG)

Date du début: 1 juin 2013, Date de fin: 31 mai 2019,

Formation of amyloid-like protein aggregates is the hallmark of a number of neurodegenerative diseases, but how the aggregation process is linked with cytotoxicity and cell death remains unclear. The goal of this pro¬ject is to elucidate the basic mechanisms of aggregate toxicity and how it affects the biological system in its entirety. We will analyse cell culture and mouse models of Huntington’s ...
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 1

 TERMINÉ 

Principles of Protein Group Modification by the SUMO Pathway (SUMOGROUP)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"Posttranslational modification (PTM) of proteins by ubiquitin family proteins is of fundamental importance for cellular function, regulation and development. Ubiquitylation typically targets individual proteins, and high selectivity is achieved by a plethora of ubiquitin-conjugating enzymes and ligases. Much less is known regarding how modification by the ubiquitin-related protein SUMO influences ...
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 1

 TERMINÉ 

Integrin: signalling from the tail and the hub (SIGNAL2THEHUB)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

...cond aim we will utilize high-resolution quantitative mass spectrometry to define how different integrins assemble adhesomes with common and specific components that signal in highly regulated manners. Our third aim will determine how integrin tails nucleate an adhesion complex that expedites further interactions with multiple binding partners by performing crosslinking proteomics of adhesion prot ...
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 1

 TERMINÉ 

Mechanistic dissection of myofibrillogenesis and sarcomerogenesis in insect muscle (FLIGHT MUSCLE)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

...instruct muscle diversity? 2) Which proteins have an essential role in myofibrillogenesis in different muscle types? 3) How are myofibrils and sarcomeres built in space and time in a muscle specific manner? My entry point is a genome-wide muscle-specific RNAi screen that identified the transcription factor Salm as selector gene for fibrillar flight muscle. Salm alone is sufficient to instruct all ...
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 2

 TERMINÉ 

Impact of virus infection on the host proteome (iViP)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

Pathogens exploit cellular resources for their own benefit and their propagation. Co-evolution of viruses and their hosts led to the establishment of very specific interactions between both partners. The balance between both, the viral attack and the cellular defense mechanisms, dictates the outcome of an infection, either leading to a cure, to disease or life-long co-existence. Efforts from many ...
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 1

 TERMINÉ 

Structural Studies and Regulation of Intraflagellar Transport Complexes (CiliTransport)

Date du début: 1 sept. 2012, Date de fin: 31 août 2017,

The cilium is an organelle that protrudes from the cell body and is responsible for the motility of unicellular organisms and of vertebrate cell types such as sperm cells. In addition, most vertebrate cells have primary non-motile cilia important for sensory reception and signalling. The assembly and function of cilia rely on intraflagellar transport (IFT), the bi-directional movement of macromole ...
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 1

 TERMINÉ 

RNA poly(A) tail: the beginning of the end (DEAD2THEEND)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

...tly alter the expression of proteins in response to changes in physiological conditions. The decay of mRNAs is performed by a set of macromolecular complexes that act in a sequential and coordinated manner, progressively eroding the ends of the transcript until its degradation is complete. These macromolecular assemblies contain only a few catalytically active subunits and a large number of regula ...
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 1

 TERMINÉ 

Characterization of a novel sorting pathway at the Trans Golgi Network (TGN) (SORTMECH)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

"The Trans Golgi Network (TGN) is the central sorting station for newly synthesised proteins in the cell. Similar to a postal distributioncenter, incoming cargo is selected, sorted, and packaged to be carried to its final cellular destination by the postman in charge. Due to theinvolvement of numerous different cargoes and pleiomorhic carriers for the different destinations this process of protein ...
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 1

 TERMINÉ 

Untangling the Bacterial Chromosome: Condensin's Role in Sister Chromosome Separation and its Mechanisms (DISENTANGLE)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2015,

...the precise role of condensin in chromosome segregation and its mechanisms are unclear.To test our hypothesis, we will establish a minichromosome in bacteria that segregates in a condensin-dependent manner and measure its decatenation in vivo in the presence and absence of condensin. We will investigate the mechanism by which condensin organizes DNA within the (mini-)chromosome using techniques li ...
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 1

 TERMINÉ 

Structural and functional studies on how the Ski complex activates the exosome to degrade RNA (Exosome-Ski-Complex)

Date du début: 1 juil. 2013, Date de fin: 30 juin 2015,

Regulation of RNA stability is recognized as a widely used strategy to regulate protein abundance in time and space in all eukaryotes. RNA degradation regulates gene expression in various processes during development and differentiation and in changing physiological conditions. Many elements of the RNA decay machinery have been identified, but details of their function remain elusive.The exosome i ...
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 1

 TERMINÉ 

Tailoring the tail of L-selectin (leukoselectin)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2015,

Leukocytes protect humans from pathogens. During episodes of infection, leukocytes leave the blood circulation and migrate to sites in the body where they mount a response against pathogens. In order for leukocytes to migrate, they must adhere to endothelial cells which cover blood vessels. Such adhesion allows them to migrate along the endothelial layer, pass though endothelial junctions, and rea ...
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 1

 TERMINÉ 

Communication of European Health Research (COMMHERE)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,

The overall aim of CommHERE is to improve communication on the outcome of EU funded health research projects to the media, the general public and other target groups including the EC in all of Europe.The CommHERE consortium comprises 10 partners, all research institutions active in the health research area. All partners are responsible for the coordination of EU-funded health research projects. Th ...
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 12

 TERMINÉ 

PROteomics SPECification in Time and Space (PROSPECTS)

Date du début: 1 avr. 2008, Date de fin: 31 mars 2013,

"Proteomics is a major new field in biomedical research, which deals with the large-scale identification and characterization of large groups of proteins, or “proteomes”. These can either be the components of a subcellular organelle or compartment, or even the entire protein complement of whole cells and tissues. Proteomics is essential in the functional annotation of the genome and in future atte ...
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 11