3 projets européens trouvés
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TERMINÉ
Development of novel treatment strategies based on knowledge of cellular dysfunction in diabetes (BetaBat)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,
A reduction in functional pancreatic beta cell mass is the key feature of type 1 and type 2 diabetes. Beta cell failure is exacerbated in the context of obesity and insulin resistance. Brown adipose tissue (BAT) is a highly metabolic organ, mediating energy dissipation and glucose disposal, thus contributing to maintain energy balance. BAT dysfunction contributes to obesity and impaired glucose me ...
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12
Participants partenaires
TERMINÉ
Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in diabetes (IMIDIA)
Date du début: 1 févr. 2010, Date de fin: 30 sept. 2015,
An absolute or relative loss of beta-cell mass and function underlie the development of type I and type 2 diabetes.Preventing beta-cell demise or restoring their number and function is a major therapeutic goal. However,development of novel diagnostic and prognostic tools, and of novel therapeutic modalities, is hampered by the limited knowledge of the molecular pathways that control beta-cell demi ...
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23
Participants partenaires
TERMINÉ
Novel immunotherapies for type 1 diabetes (NAIMIT)
Date du début: 1 nov. 2009, Date de fin: 30 avr. 2015,
This proposal will pioneer the concept of tailored interventions with minimal immune system interference in new onset T1DM, leading to beta-cell protection and restoration, based on a solid understanding of the disease pathogenesis. This will enable experimental findings to be adopted for future clinical application. Four work packages are grouped around ‘Reversal of autoimmunity’, in which two ke ...
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