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 TERMINÉ 

Beta-cell function in juvenile diabetes and obesity (Beta-JUDO)

Date du début: 1 févr. 2012, Date de fin: 30 nov. 2016,

The number of individuals with obesity and type 2 diabetes mellitus (T2DM) is increasing. An alarming aspect is decline in age of onset of T2DM, which is coupled to rise in childhood obesity. Accentuated insulin secretion is observed early in young obese individuals. In many subjects insulin hypersecretion is evident when insulin sensitivity is essentially normal. Based on these observations we pr ...
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 TERMINÉ 

HER Imaging and Molecular Interaction Mapping in Breast Cancer (IMAGINT)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2015,

The aim is to develop tools for imaging and characterising protein/protein and protein/RNA interactions in cancer using Designed Ankyrin Repeat Proteins (DARPins). DARPins are small, ultrahighly stable, antibody-like proteins that bind specific targets with high affinity in monovalent form and are readily engineered for site-specific chemical modification. The exemplar protein family will be EGFR, ...
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