3 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Unraveling the role of Alu RNAs accumulation in cancer progression (CanAlu)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,
Background and rationale: The Alu repeat elements are the most abundant short interspersed repeated elements (SINEs) in human genome. Recently, the accumulation of Alu RNA transcripts, following DICER1 deficit, has been shown to be responsible for a human disease, the dry form of age-related macular degeneration (AMD), Geographic Atrophy (GA). Interestingly, increased levels of Alu RNAs and reduce ...
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1
Participant partenaire
TERMINÉ
Studying Physiology and Pathology of Imprinted Genes to understand the role of Epigenetic Mutations in Human Disease (INGENIUM)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,
"The aim of this ITN is to promote research and training in the field of epigenetics associated with human disease. Expression of imprinted genes is mono-allelic and gamete of origin-dependent. This is due to different epigenetic modifications present on the maternal and paternal chromosomes. Failure in normal establishment, maintenance or erasure of these marks results in gene dosage dysregulatio ...
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10
Participants partenaires
TERMINÉ
Activation of vasculature associated stem cells and muscle stem cells for the repair and maintenance of muscle tissue (Endostem)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,
We propose to develop new strategies to mobilize skeletal muscle tissue-associated stem cells as a tool for efficient tissue repair. This will be combined with exploring novel approaches that limit tissue damage, and will focus on agents that modify muscle and muscle vasculature progenitor cells. These molecules include nitric oxide associated with non-steroidal anti-inflammatory drugs, HMGB1, Cri ...
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