11 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Setting an interdisciplinary/sectorial/international research network to explore dry storage as an alternative strategy for cells/germplasm biobanking (DRYNET)
Date du début: 1 mars 2017, Date de fin: 28 févr. 2021,
The number of biobanks for diagnostic/clinical/biodiversity preservation purposes is increasing exponentially, representing an economic burden for the EU. Cryopreservation (Liquid Nitrogen LN) is the only cells/gametes long-term repository method. LN storage is expensive though, requires dedicated facilities, is hazardous, carries pathogens and has high carbon footprint. DRYNET objective is to set ...
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8
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TERMINÉ
Molecular strategies to treat inherited arrhythmias (EU-rhythmy)
Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,
Sudden cardiac death (SCD) is a leading cause of death in western countries: coronary artery disease is the major cause of SCD in older subjects while inherited arrhythmogenic diseases are the leading cause of SCD in younger individuals. After 25 years dedicated to research of the molecular bases of heritable arrhythmias, the PI of this proposal now intends to pioneer gene therapy for prevention o ...
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3
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TERMINÉ
Mitochondrial Medicine: developing treatments of OXPHOS-defects in recombinant mammalian models (MITCARE)
Date du début: 1 juil. 2013, Date de fin: 30 juin 2018,
Mitochondria are the major source of ATP, synthesized by the mitochondrial respiratory chain (MRC) through the process of oxidative phosphorylation. ATP deficiency leads to cellular dysfunction and ultimately death. In mammals, 13 mitochondrial DNA (mtDNA)-encoded subunits interact with over 70 nuclear-encoded subunits to form four of the five MRC complexes. Many additional factors are essential f ...
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3
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TERMINÉ
Macroencapsulated Porcine Pancreatic Islets to cure Diabetes Mellitus type 1/2 (XENOISLET)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
...ter transplantation of subcutaneous alginate macroencapsulated porcine islets xenograft without the use of any immunosuppression. In order to improve the function of pig islets, we have produced with AVANTEA a transgenic pig expressing GLP-1 at the level of the pig islets. In fact, GLP1 is not only able to (i) increase the insulin gene expression and insulin biosynthesis, but also to (ii) induce t ...
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5
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TERMINÉ
Defining the role of xeno-directed and autoimmune events in patients receiving animal-derived bioprosthetic heart valves (TRANSLINK)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
TRANSLINK is a project devoted to assessing the mid-to long-term risk factors and improve the outcome of animal (bovine/porcine)-derived Bioprosthetic Heart Valve (BHV) implants. 300,000 patients/year benefit from BHV, a major healthcare problem (second most frequent cardiac surgery). BHV clinical outcome suffers from late dysfunctions restricting their application to older recipients. Based on a ...
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14
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TERMINÉ
EpiHealthNet
Date du début: 1 mai 2013, Date de fin: 30 avr. 2017,
Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life.Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity fornewly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient deli ...
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9
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TERMINÉ
Optimisation of early reproductive success in dairy cattle through the definition of new traits and improved reproductive biotechnology (FECUND)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2017,
"Good fertility is essential for the sustainability of livestock production. Of all livestock sectors, fertility of dairy cattle is raising the greatest cause for concern. Cow fertility has declined, particularly in Holstein cattle, from 80% pregnancy to first service 20 years ago to less than 40% today. Poor fertility is one of the main reasons for early culling, such that modern dairy cows compl ...
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13
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TERMINÉ
Stem Cells for Relevant Efficient Extended and Normalized Toxicology (SCR&TOX)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,
In the development of products for use by humans it is vital to identify compounds with toxic properties at an early stage of their development, to avoid spending time and resource on unsuitable and potentially unsafe candidate products. Human pluripotent stem cell lines offer a unique opportunity to develop a wide variety of human cell-based test systems because they may be expanded indefinitely ...
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16
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TERMINÉ
Linking perturbed maternal environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing (EpiHealth)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life. Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity for newly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient de ...
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7
Participants partenaires
TERMINÉ
Embryonic Stem cell-based Novel Alternative Testing Strategies (ESNATS)
Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,
"ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to ...
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34
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TERMINÉ
Systems biology approaches to understand cell pluripotency Acronym: PluriSys (PluriSys)
Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,
The PluriSys project is aimed at increasing the fundamental knowledge of basic biological processes of cell pluripotency and differentiation by generating new holistic data on gene expression and epigenetic modifications associated with cell pluripotency. The project integrates the multidisciplinary excellence in Europe in cell biology, molecular biology and bioinformatics. It also builds on earli ...
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