2 projets européens trouvés
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TERMINÉ
REgeneration of inner ear hair cells with GAmma-secretase INhibitors to regain hearing in patients with sensorineural hearing loss (REGAIN)
Date du début: 1 mai 2015, Date de fin: 31 oct. 2018,
Hearing loss is a chronic non-communicable disease disabling over 328 million adults, and 32 million children worldwide. Sensorineural hearing loss due to loss of auditory hair cells was long thought to be irreversible. However, recent animal studies have demonstrated that pharmacological inhibition of cell signalling via Notch receptors using gamma-secretase inhibitors (GSIs) can regenerate hair ...
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TERMINÉ
Human stem cell applications for the treatment of hearing loss (OTOSTEM)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
Hearing impairment is the most frequent human sensory deficit and is mainly caused by the irreversible loss of neurosensory cells in the cochlea. The lack of human otic cell models represents a significant roadblock that has hampered the development of drug-based or cell-based therapies for the treatment of hearing loss. In a collaborative effort under this proposal we wish to devise approaches to ...
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